Botulinum Toxin Type A and the Prevention of Hypertrophic Scars on the Maxillofacial Area and Neck: A Meta-Analysis of Randomized Controlled Trials

Zhang, Dai-zun; Liu, Xiaoya; Xiao, Wen‐lin; Xu, Yaoxiang

doi:10.1371/journal.pone.0151627

Cited by 40 publications

(25 citation statements)

References 34 publications

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“…1,26 A recent meta-analysis demonstrated that botulinum toxin significantly reduced the width of hypertrophic scars, improved their appearance on visual analog scales, and improved overall patient satisfaction. 27 Botulinum toxin does not have an immediate onset of action; however, when used as an adjunct during scar revision, patients should undergo injection 2 weeks prior to surgical revision. 1…”

Section: Botulinum Toxinmentioning

confidence: 99%

Management of Facial Scars

et al. 2019

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Scarring is a natural process of healing after damage to the skin that extends to the reticular dermis. While some scars may be socially acceptable, even admirable, scars of the face can be viewed as disfiguring or ugly. Minimizing the appearance of facial scars and optimizing their cosmetic outcome ideally begin before surgery or, in the cause of trauma, at the initial reconstruction. Even when there has been poor initial healing, a scar's appearance can be improved. Herein, we review conservative, medical, and surgical therapies to improve the appearance of facial scars.

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Section: Botulinum Toxinmentioning

confidence: 99%

Management of Facial Scars

et al. 2019

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“…Moreover, some animal studies demonstrated the usefulness of BTX in scar and keloid reduction [20], [21], [22]. Despite all differences in published studies a recent meta-analysis of randomised controlled trials evaluating BTX effect in the face/neck area has found that patients who received BTX had better outcomes than those who did not receive it [24]. According to this study the scars were significantly narrower ( P = 0.006) and visual analogue scale scores were significantly better, indicating that patients treated with BTX were more satisfied with the results than those who received saline.…”

Section: Resultsmentioning

confidence: 99%

Botulin Toxin Use in Scars/Keloids Treatment

Scala¹,

Vojvodić²,

Vojvodić³

et al. 2019

Open Access Maced J Med Sci

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Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions which include scar prevention and treatment with good results. The complex mechanism underlying those results is not completely understood but several mechanisms were proposed: release inhibition of different substances like (TGF)-β, substance P, calcitonin gene-related peptide (CGRP) and glutamate thus modulating cutaneous inflammation and wound healing. We analysed the published data on BTX off label applications on scars and keloids retrieved from PubMed.

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“…22 The analysis found that scars were significantly narrower ( P = 0.006) and visual analog scale (VAS) scores were significantly higher, indicating that patients receiving BoNT-A were more satisfied with the results than those who received saline. However, the number of studies eligible for the analysis was small (9) and only 3 were unbiased in all assessment domains.…”

Section: Aesthetic Developmentsmentioning

confidence: 97%

New Uses of AbobotulinumtoxinA in Aesthetics

Schlessinger¹,

Gilbert²,

Cohen³

et al. 2017

Aesthetic Surgery Journal

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BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. These may be achieved through use of combinations of BoNT-A with other aesthetic procedures, tailoring the dose of toxin to the patient’s muscle mass or by using novel injection and application techniques. Beyond amelioration of facial lines, encouraging results have been seen with the use of BoNT-A to improve the appearance of hypertrophic and keloid scars and even to prevent them. Studies have been conducted with scars in various parts of the body and further research is ongoing. Dermatological and other medical uses for BoNT-A are also active areas of research. Injections of BoNT-A have been shown to reduce signs and symptoms of acne, rosacea, and psoriasis, to reduce neuromuscular pain, and to bring about significant improvements in a number of rare diseases that are caused or exacerbated by hyperhidrosis. This paper reviews these new uses for BoNT-A, looking at the rationale for their use and discussing the results of published case studies and clinical trials. These areas have shown great promise to date, but more and larger clinical studies will be required before these treatments become a clinical reality. To this end details are also provided of clinical trials currently listed in the main clinical trials database to highlight research areas of particular interest.

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Botulinum Toxin Type A and the Prevention of Hypertrophic Scars on the Maxillofacial Area and Neck: A Meta-Analysis of Randomized Controlled Trials

Cited by 40 publications

References 34 publications

Management of Facial Scars

Management of Facial Scars

Botulin Toxin Use in Scars/Keloids Treatment

New Uses of AbobotulinumtoxinA in Aesthetics

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