Botulinum Toxin Type A in Combination With Standard Urotherapy for Children With Dysfunctional Voiding

Petronijevic, Vesna; Milica, Lazovic; Vlajković, Marina; Slavkovic, Andjelka; Golubovic, Emilija; P, Miljković

doi:10.1016/j.juro.2007.08.027

Cited by 28 publications

(19 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Promising data on the efficacy of botox injections into the external sphincter have been reported in a small group of children with DV resistant to other therapies [66, 67]. BTA leads to temporary paralysis of the external sphincter and may decrease functional bladder outlet obstruction.…”

Section: Day Wettingmentioning

confidence: 99%

The management of childhood urinary incontinence

2014

View full text Add to dashboard Cite

The International Children’s Continence Society (ICCS) has undertaken an enormous effort to standardize both the terminology and management of various aspects of incontinence in children, including enuresis, bladder overactivity, dysfunctional voiding and psychological comorbidities. A number of guidelines have been published to aid those involved in the care of children with lower urinary tract symptoms. This review addresses a number of recommended diagnostic and therapeutic strategies, including urotherapy and pharmacological treatment, with emphasis on a focused medical history, information acquired from bladder diaries and uroflow evaluations. The major role of urotherapy is underlined with supportive pharmacotherapy, when indicated. The article provides both a summary of ICCS guidelines and a brief review of recently published papers related to the contemporary management of childhood incontinence, a health issue still underestimated by both the child’s caregivers and healthcare providers.

show abstract

Section: Day Wettingmentioning

confidence: 99%

The management of childhood urinary incontinence

2014

View full text Add to dashboard Cite

show abstract

“…However, patients were selected purely on a clinical basis without the use of uroflowmetry or EMG. For patients refractory to biofeedback and α blockers, Radojicic et al [29] and Petronijevic et al [30] have demonstrated temporary clinical and urodynamic efficacy injecting botulinum toxin type A into the pelvic floor and/or external sphincter. An interesting approach that could be applied to refractory cases is the use of intermittent catheterization; Pohl et al [31] showed that once accepted and performed, intermittent catheterization was able to control incontinence in 16 children.…”

Section: Refractory Dysfunctional Voidingmentioning

confidence: 99%

Biofeedback in the Management of Urinary Continence in Children

Palmer

2010

Curr Urol Rep

View full text Add to dashboard Cite

Significant progress has been made over the past 15 years regarding the development of bladder control and the evaluation and management of pediatric voiding dysfunction. Incontinence is a problem of significant social consequence that is commonly due to dysfunctional voiding (ie, discoordination between the detrusor and the external sphincter). Biofeedback was introduced in 1979 but was relatively forgotten until the late 1990 s. Nonanimated biofeedback relates sphincter activity to electromyographic activity as reflected as tracing on a computer screen or auditory feedback. This successful modality was exclusively available until recently when animated biofeedback became available, allowing for a more rapid grasp of the physiologic event to be modulated. Biofeedback has been shown to be very effective in children to correct incontinence secondary to dysfunctional voiding, as well as in treating giggle incontinence and to help resolve vesicoureteral reflux.

show abstract

“…The authors reported improved voiding pattern though unlike the preceding study there were limited data quantifying the changes following injection. The more recent and smaller study by Petronijevic et al addressed the possible role of botulinum toxin in conjunction with standard therapy for nine girls with refractory voiding dysfunction, with uroflowmetry and symptom score assessment at 6 months [38]. The authors of these papers did acknowledge the paucity of long-term data, and need to establish whether restoration of normal voiding was maintained.…”

Section: Sphincter Dysfunctionmentioning

confidence: 99%

Botulinum toxin in paediatric urology: a systematic literature review

Dasgupta

Murphy²

2008

Pediatr Surg Int

View full text Add to dashboard Cite

The use of botulinum toxin in paediatric urology has become increasingly widespread during recent years; however, the evidence base for its clinical use has been from adult urology centres and trials. The mechanism of action of this potent neurotoxin is discussed and evidence for its efficacy and safety is reviewed in both the adult and paediatric literature. Second, an electronic literature search was performed using the keywords paediatric urology, botulinum toxin, bladder, sphincter, and voiding dysfunction (excluding abstracts, letters and case reports). A total of 225 children in 10 peer-reviewed publications were evaluated with 165 paediatric patients with neurogenic overactivity (6 studies), 21 patients with idiopathic overactivity (1 study) and 39 patients with voiding dysfunction (3 studies). Specifically, we discuss the main indications of intravesical injections for detrusor overactivity and of intrasphincteric injections for refractory voiding dysfunctions in the paediatric population.

show abstract

Botulinum Toxin Type A in Combination With Standard Urotherapy for Children With Dysfunctional Voiding

Abstract: Our study demonstrates that the voiding mechanism in children with dysfunctional voiding refractory to standard therapy can be significantly improved and maintained at least 6 months after combined botulinum toxin type A injection and bladder rehabilitation.

Cited by 28 publications

References 11 publications

The management of childhood urinary incontinence

The management of childhood urinary incontinence

Biofeedback in the Management of Urinary Continence in Children

Botulinum toxin in paediatric urology: a systematic literature review

Contact Info

Product

Resources

About