BOTULINUM TOXINS FOR tHE TREATMENT OF PAIN

Apostol, Catalina; Abdi, Salahadin; Moeller-Bertram, Tobias; Smith, Howard S.; Argoff, Charles E.; Wallace, Mark

doi:10.1016/b978-1-4160-4836-7.00067-5

Cited by 2 publications

(3 citation statements)

References 117 publications

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“…Rarely, an allergic reaction can be triggered and injection in areas near the neck and mouth can cause dysphagia. Headache, lethargy, and muscle pain can appear when an excessive dosage is used, but all side effects are temporary and reversible [ 7 ].…”

Section: Usage Side Effects and Precautionsmentioning

confidence: 99%

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Application of Botulinum Toxin in Pain Management

Sim

2011

Korean J Pain

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Botulinum toxin has been used for the treatment of many clinical disorders by producing temporary skeletal muscle relaxation. In pain management, botulinum toxin has demonstrated an analgesic effect by reducing muscular hyperactivity, but recent studies suggest this neurotoxin could have direct analgesic mechanisms different from its neuromuscular actions. At the moment, botulinum toxin is widely investigated and used in many painful diseases such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Further studies are needed to understand the exact analgesic mechanisms, efficacy and complications of botulinum toxin in chronic pain disorders.

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Section: Usage Side Effects and Precautionsmentioning

confidence: 99%

“…BTX injection is also prohibited in children less than 12 years of age and pregnant and nursing mothers. Caution is needed for patients with peripheral motor neuron disease, neuromuscular conduction disease, and those taking drugs that can interfere with neuromuscular conduction [ 7 ].…”

Section: Usage Side Effects and Precautionsmentioning

confidence: 99%

Application of Botulinum Toxin in Pain Management

Sim

2011

Korean J Pain

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“…Asimismo se ha descrito la aparición de un cuadro de mayor severidad y duración compatible con síntomas pseudogripales. Su incidencia oscila entre el 1,7-20% tras infiltración con toxina botulínica serotipo A, su aparición puede ser tardía, incluso un mes tras administración, relacionándose con fenómenos de inmunogenicidad (13)(14)(15).…”

Section: Discussionunclassified

Desarrollo de miastenia gravis tras administración de toxina botulínica en el síndrome de dolor miofascial

Velazquez¹,

Delgado

Vázquez³

et al. 2015

Rev. Soc. Esp. Dolor

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Myofascial pain syndrome is a painful muscle condition which is defined as local or referred pain associated with hypersensitive palpable nodules in the way of that muscle and is a frequent pathology in consultations on chronic pain. Botulinum toxin is an exotoxin produced by Clostridium botulinum, of which serogroups A, B and F have clinical utility (mainly type A-Botox ® , Dysport ®). This is one of the most potent neurotoxins and is administered compassionatelly in the treatment of myofascial pain syndrome. The toxin has a beneficial analgesic effect by reducing muscle hyperactivity but recent studies suggest that this neurotoxin may also induce analgesia by non-neuromuscular actions. Its use is not without risks. Adverse effects are related to the migration of the toxin and are usually mild or moderate and transient. There have been reports of prolonged muscle weakness and diseases like myasthenia gravis or Lambert Eaton syndrome triggered by the use of the toxin. We report a case of a male patient with myofascial pain syndrome whose psoas and quadratus muscles were treated with injections of botulinum toxin. Following the improvement in clinical muscle situation, repetitive diplopia and ptosis developed and the patient was diagnosed of myasthenia gravis. We review the pathogenesis of myofascial pain syndrome and myasthenia gravis and the use of botulinum toxin and relationships between them. We conclude that a detailed history is required prior to the use of botulinum toxin on patients with muscle pathology or signs of muscle weakness.

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BOTULINUM TOXINS FOR tHE TREATMENT OF PAIN

Cited by 2 publications

References 117 publications

Application of Botulinum Toxin in Pain Management

Application of Botulinum Toxin in Pain Management

Desarrollo de miastenia gravis tras administración de toxina botulínica en el síndrome de dolor miofascial

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