“…When a cost functional measuring the discrepancy between solutions and target functions is formulated, constrained optimization techniques are employed (one-shot, sensitivity or adjoint-based methods) to construct an iterative algorithm [10,29] for estimating model parameters. There are numerous works in the literature that apply optimal control theory to reaction-diffusion systems [4][5][6]8,12,13,16,19,20,45]. However, relatively few works focus on estimating parameters in nonlinear reaction-diffusion systems [1,14,24,28], and to the best of our knowledge, none address parameter estimation for the Turing reaction-diffusion model.…”