We study the non-autonomous version of an infinite-dimensional linear port-Hamiltonian system on an interval [a, b]. Employing abstract results on evolution families, we show C 1 -well-posedness of the corresponding Cauchy problem, and thereby existence and uniqueness of classical solutions for sufficiently regular initial data. Further, we demonstrate that a dissipation condition in the style of the dissipation condition sufficient for uniform exponential stability in the autonomous case also leads to a uniform exponential decay rate of the energy in this non-autonomous setting.