Combined impacts of prescribed surface heat and mass fluxes on nanoliquid flow over a vertical plate with shear flow have been inspected. A two‐phase model for nanofluid has been considered. By means of similarity alterations, partial differential equations which govern the problem under consideration are changed to ordinary ones and nonlinear equations are solved numerically by shooting technique and Runge–Kutta method. The related effects of appropriate parameters on streamwise velocity, velocity, velocity gradient, temperature, and concentrations are analyzed elaborately. The importance of unlike factors on heat and mass transport as well as fluid flow phenomena are detected and analyzed physically as far as practicable. Fluid velocity rises but temperature and concentration are noted to diminish due to mixed convection. Velocity gradient at the wall rises with the rise in mixed convection parameter but wall temperature and wall concentration are found to diminish with the growing values of mixed convection parameter. As Brownian motion parameter and thermophoresis parameter increase, the wall velocity gradient declines until a certain point and from that point it starts to behave in the opposite way. Additionally, the temperature at the wall increases as these parameters grow, but temperature at the wall decreases with the rising values of the mixed convection parameter. On the other hand, the wall concentration increases with the increasing values of the thermophoresis parameter, but wall concentration decreases with the swelling values of the Brownian motion parameter and mixed convection parameter. The results of this study will be of immense help to the engineers and scientists to obtain superior flow phenomenon and heat, mass transport features.