The Input-to-State Stability of the non-horizontal cascade channels with different arbitrary cross section, slope and friction modeled by Saint-Venant equations is addressed in this paper. The control input and measured output are both on the collocated boundary. The PI control is proposed to study both the exponential stability and the output regulation of the closed-loop systems with the aid of Lyapunov approach. An explicit quadratic Lyapunov function as a weighted function of a small perturbation of the non-uniform steady-states of different channels is constructed. We show that by a suitable choice of the boundary feedback controls, the local exponential stability and the Input-to-State Stability of the nonlinear Saint-Venant equations for the H 2 norm are guaranteed, then validated with numerical simulations. Meanwhile, the output regulation and the rejection of constant disturbances are realized as well.