After the many ups and downs over the past 70 years of AI and 50 years of data science (DS), AI/DS have migrated into their new age. This new-generation AI/DS build on the consilience and universology of science, technology and engineering. In particular, it synergizes AI and data science, inspiring Trans-AI/DS (i.e., Trans-AI, Trans-DS and their hybridization) thinking, vision, paradigms, approaches and practices. Trans-AI/DS feature their transformative (or transformational), transdisciplinary, and translational AI/DS in terms of thinking, paradigms, methodologies, technologies, engineering, and practices. Here, we discuss these important paradigm shifts and directions. Trans-AI/DS encourage big and outside-the-box thinking beyond the classic AI, data-driven, model-based, statistical, shallow and deep learning hypotheses, methodologies and developments. They pursue foundational and original AI/DS thinking, theories and practices from the essence of intelligences and complexities inherent in humans, nature, society, and their creations.