We extend the Burger–Mozes theory of closed, nondiscrete, locally quasiprimitive automorphism groups of locally finite, connected graphs to the semiprimitive case, and develop a generalization of Burger–Mozes universal groups acting on the regular tree
$T_{d}$
of degree
$d\in \mathbb {N}_{\ge 3}$
. Three applications are given. First, we characterize the automorphism types that the quasicentre of a nondiscrete subgroup of
$\operatorname {\mathrm {Aut}}(T_{d})$
may feature in terms of the group’s local action. In doing so, we explicitly construct closed, nondiscrete, compactly generated subgroups of
$\operatorname {\mathrm {Aut}}(T_{d})$
with nontrivial quasicentre, and see that the Burger–Mozes theory does not extend further to the transitive case. We then characterize the
$(P_{k})$
-closures of locally transitive subgroups of
$\operatorname {\mathrm {Aut}}(T_{d})$
containing an involutive inversion, and thereby partially answer two questions by Banks et al. [‘Simple groups of automorphisms of trees determined by their actions on finite subtrees’, J. Group Theory18(2) (2015), 235–261]. Finally, we offer a new view on the Weiss conjecture.