Bovine Based Collagen Dressings in Wound Care Management

Abstract

Collagen plays a significant role in treating acute and chronic wounds such as cuts, burns, ulcers associated with other illness via enhancing the debridement of infected tissues, angiogenesis and promoting natural growth. There are several types of collagen, which can be obtained from various animal sources such as chicken, bovine, porcine, fish etc. Among that bovine based collagen contributed many shares towards biomedical application. Nowadays using bovine based collagen biomaterials for wound care is in trend to minimize the negative impacts such as infection, pain and other side effects. However, its applicable and effectiveness are not fully revealed. At the same time, clinicians and researchers are exploring and implementing advanced techniques and treatment procedures to reduce the wound healing burden effectively. In this review, we aimed to focus on the fundamental information about types of wound dressings, collagen dressings and the clinical utility of bovine based collagen dressings in providing essential knowledge in advanced wound care management.

Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models

“…Collagen is naturally degraded by metalloproteinases, specifically collagenases and serine proteases, so that its degradation is under the local control of cells in cultured tissue [3]. Literature data also mention collagen and chitosan-derived hydrogels used in the treatment of wounds due to hemostatic and antimicrobial effects, correlated with good biocompatibility [19].…”

“…To determine the linear viscoelastic range and the structure stability of samples, the amplitude sweep test (γ= 0.001-100%, ω = 10 rad/s) was performed (Figure 1). extracted from animal's tissues such as skin, bones, and tendons [3].…”

“…Finding less traumatic methods of treatment is imperiously required and the final goal in wound healing research is to achieve a cure through a regeneration process. The dermis contains a series of proteins of which the collagen polymer, responsible for the tensile strength of the skin, has an important percentage (~70-80% of the dry weight) [3].…”

“…Collagenbased materials have numerous applications in the tissue regeneration field due to their biocompatibility properties. On the other hand, this polymer is one of the main materials Pharmaceuticals 2021, 14, 465 2 of 17 present in the architecture of the living matter and can be efficiently extracted from animal's tissues such as skin, bones, and tendons [3].…”

Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study

“…In addition, wound dressings should reduce healing time, have no side effects and improve bioavailability [15]. Recently, Santhanam et al [16] have reviewed that bovine collagen is considered as a good source of natural collagen and can be used as a potential dressing in wound care management.…”