Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status

Boysen, Preben; Olsen, Ingrid; Berg, Ingvild; Kulberg, Siri; Johansen, G.; Storset, Anne K.

doi:10.1186/1471-2172-7-10

Cited by 49 publications

(36 citation statements)

References 51 publications

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“…2c). In accordance with this finding, bovine CD2 − NK cells have been shown to be preferentially activated when stimulated with interleukin‐2 31. Furthermore, the expression of a second activation marker, CD44, was found to be significantly increased in AL NK cells, which highlights an overall activated phenotype within AL 23.…”

Section: Discussionsupporting

confidence: 71%

Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood

et al. 2017

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SummaryNatural killer (NK) cells are widely distributed in lymphoid and non‐lymphoid tissues, but little is known about the recirculation of NK cells between blood and tissues. This is relevant to understanding recirculation in the steady‐state and also for determining the roles for NK cells in vaccine‐induced immunity and responses to infection. Therefore, the percentage of NK cells and their phenotype across peripheral blood, afferent lymph and lymph nodes in steady‐state conditions was investigated in cattle using the pseudo‐afferent lymphatic cannulation model. CD2+ CD25lo NK cells were the predominant subset of NK cells within the blood. In contrast, CD2− CD25hi NK cells were the main subset present within the skin‐draining afferent lymphatic vessels and lymph nodes, indicating that CD2− NK cells are the principal NK cell subset trafficking to lymph nodes via the afferent lymphatic vessel. Furthermore, a low percentage of NK cells were present in efferent lymph, which were predominantly of the CD2− subset, indicating that NK cells can egress from lymph nodes and return to circulation in steady‐state conditions. These compartmentalization data indicate that NK cells represent a population of recirculating lymphocytes in steady‐state conditions and therefore may be important during immune responses to vaccination or infection.

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Section: Discussionsupporting

confidence: 71%

Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood

et al. 2017

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“…The CD2 ϩ subset usually comprises a smaller proportion of the cells than the CD2 Ϫ subset in young animals (9). The role of NK and ␥␦ T lymphocytes in immunity and immunopathogenesis of JD is unclear, but they may be a source of cytokines that modulate immune responses (6,25,30,47). The majority of freshly isolated bovine NK cells express CD2.…”

Section: Discussionmentioning

confidence: 99%

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Allen

Park

Barrington

et al. 2009

Clin Vaccine Immunol

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“…Upon activation by the cytokines TNFα, IFNα/IFNβ, IL-12, IL-15 or IL-18 produced by accessory cell populations such as antigen presenting cells (APC), NK cells have two main effector functions. Firstly, NK cells are a significant source of immunoregulatory cytokines, primarily IFNγ but also TNFα, GM-CSF [ 97 – 99 ], IL-10 [ 98 , 99 ] and IL-22 [ 100 , 101 ]. Secondly, NK cells display cytotoxicity to target cells through the release of preformed, cytotoxic granules containing perforin and granulysin [ 102 ].…”

Section: Immunology Of Cryptosporidiosismentioning

confidence: 99%

Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies

Thomson

Hamilton

Hope

et al. 2017

Vet Res

226

234

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Gastrointestinal disease caused by the apicomplexan parasite Cryptosporidium parvum is one of the most important diseases of young ruminant livestock, particularly neonatal calves. Infected animals may suffer from profuse watery diarrhoea, dehydration and in severe cases death can occur. At present, effective therapeutic and preventative measures are not available and a better understanding of the host–pathogen interactions is required. Cryptosporidium parvum is also an important zoonotic pathogen causing severe disease in people, with young children being particularly vulnerable. Our knowledge of the immune responses induced by Cryptosporidium parasites in clinically relevant hosts is very limited. This review discusses the impact of bovine cryptosporidiosis and describes how a thorough understanding of the host–pathogen interactions may help to identify novel prevention and control strategies.

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Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status

Cited by 49 publications

References 51 publications

Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood

Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood

Development of a Bovine Ileal Cannulation Model To Study the Immune Response and Mechanisms of Pathogenesis of Paratuberculosis

Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies

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