Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial

Barakat, Sana H.; Meheissen, Marwa Ahmed; Omar, Omneya Magdy; Elbana, Doaa Ali

doi:10.1093/tropej/fmz029

Cited by 16 publications

(37 citation statements)

References 29 publications

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“…Figure 1 represents the Flow Chart of the study selection process. Twenty-four out the 28 studies included the full texts [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], while 4 were available as abstracts only [ 56 , 57 , 58 , 59 ]. The majority of these articles involved participants from Europe ( n = 14; 52%), 6 (22%) from Asia, 3 (11%) from Africa 1 (4%) from America and 3 (11%) from Oceania.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the papers were classified by publication type (full texts or abstracts), BC administration route (systemic oral or topical) and study population. BC topical application in uro-gynecology [ 33 , 34 , 35 ] ( Table 2 ), BC as dietary supplement in the sporting population [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] ( Table 3 ), BC as dietary supplement in the pediatrics and preterm infants [ 47 , 48 , 49 , 50 , 51 , 52 , 53 ] ( Table 4 ), BC as dietary supplement in the elderly [ 54 ] ( Table 5 ), BC administration in critically ill patients [ 55 ] ( Table 6 ), abstracts [ 56 , 57 , 58 , 59 ] ( Table 7 ) and then a systematic review on BC clinical applications [ 21 ] ( Table 8 ). In Table 9 the risk of bias of the included (full texts) RCTs was reported according to the CCRBT method.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies (1 RCT, 2 OS) were on topical applications of BC-based creams on various vaginal conditions and recruiting only female participants with a mean age ranged from 27 to 61 years [ 33 , 34 , 35 ]. Twenty-four papers (23 RCTs, 1 OS) assessed the efficacy of BC as dietary supplement in various populations [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], including diseased ones [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 55 , 56 , 57 , 58 , 59 ] and healthy people [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ...…”

Section: Resultsmentioning

confidence: 99%

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Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

et al. 2021

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Colostrum is the first secretion of mammalian glands during the early period after birth giving. Its components are biologically active and have beneficial effects on new-born growth and well-being. Bovine colostrum has the highest concentration of these substances and its supplementation or application may provide health benefits. This systematic review was conducted to update current knowledge on bovine colostrum effects including all administration routes on healthy and sick subjects. Full texts or abstracts of twenty-eight papers as reports of systematic reviews, randomized controlled trials, observational studies and case series were included after searches in Medline, Embase, Cochrane Library and Cinahl databases. The full texts of selected studies were assessed for quality using validated tools and their results were summarized in different categories. Studies were highly heterogeneous as regards to population, intervention, outcome and risk of bias. Bovine colostrum topical application was shown effective on vaginal dryness related symptoms limitation. Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen, modulating immune system response and reducing intestinal permeability in healthy and sick subjects. Conflicting results were provided in pediatric population and little evidence is available on its use with older adults. Further studies are mandatory to better understand all factors influencing its activity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

et al. 2021

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“…BC treatment was associated with reductions in stool frequency and occurrence of diarrhea compared to placebo. Since that analysis was undertaken, Barakat et al [49] evaluated the effect of giving BC to children under 5 years in Egypt who had acute diarrhea. In this double-blind randomized controlled trial, 160 children were enrolled with half receiving BC in addition to standard care for acute diarrhea, while the other half only received standard care.…”

Section: Infectious Diarrheamentioning

confidence: 99%

Colostrum Therapy for Human Gastrointestinal Health and Disease

Chandwe

Kelly

2021

Nutrients

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There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier. Bovine colostrum is a complex biological fluid replete with growth factors, nutrients, hormones, and paracrine factors which have a range of properties likely to contribute to mucosal healing in a wide range of infective, inflammatory, and injury conditions. In this review, we describe the anatomy and physiology of the intestinal barrier and how it may fail. We survey selected diseases in which disordered barrier function contributes to disease pathogenesis or progression, and review the evidence for or against efficacy of bovine colostrum in management. These disorders include enteropathy due to non-steroidal anti-inflammatory drugs (NSAIDs), inflammatory bowel disease (IBD), necrotizing enterocolitis, infectious diarrhea, intestinal failure, and damage due to cancer therapy. In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure. In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea. Given the robust scientific rationale for using bovine colostrum as a promoter of mucosal healing, further work is needed to define its role in therapy.

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“…Bovine colostrum milk (bCM) is rich in immunoglobulins [ 24 , 25 ], lactoferrin [ 26 , 27 ], free oligosaccharides, oligosaccharide-containing glycoproteins [ 28 , 29 ], and lactoperoxidase [ 30 ]. In fact, bCM has been used to treat acute diarrhea [ 31 , 32 ] and other gastrointestinal infections [ 33 , 34 , 35 ]. BCM was also shown to reduce huNoV VLP binding to human intestinal Caco-2 cells [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Functional Components in Bovine Colostrum That Inhibit Norovirus Capsid Protruding Domains Interacting with HBGA Ligands

et al. 2021

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Human noroviruses (huNoVs) cause epidemic acute gastroenteritis with significant mortality and morbidity worldwide. However, there are no commercial vaccines or antivirals against these important pathogens so far. In this study, we found that bovine colostrum (bCM) inhibited huNoV VLPs and their capsid-protruding (P) domains binding to histo-blood group antigens (HBGAs) that are huNoV receptor or attachment factors for infection, suggesting that bCM may function as a natural antiviral against huNoVs. We then characterized the bCM for the functional inhibition components by sequentially separating bCM into multiple fractions through various chromatography approaches, followed by determining their inhibitory abilities against huNoV receptor-binding P protein interacting with HBGAs. The protein components of bCM functional fractions were examined by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Our data suggested that some milk proteins, likely in the form of glycoproteins, contribute to the observed blocking effects of bCM. Our findings lay an important foundation to further develop bCM into a potential natural antiviral against huNoVs.

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Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial

Cited by 16 publications

References 29 publications

Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

Colostrum Therapy for Human Gastrointestinal Health and Disease

Characterization of Functional Components in Bovine Colostrum That Inhibit Norovirus Capsid Protruding Domains Interacting with HBGA Ligands

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