1979
DOI: 10.1159/000149042
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Bovine Enterovirus CPE at Different Multiplicities of Infection in the Absence of Viral RNA Synthesis

Abstract: When bovine enterovirus (BEV) RNA synthesis was inhibited by 2-(α-hydroxy-benzyl)-benzimidazole (HBB), an increase in MOI was accompanied by an enhancement of cytopathology. Since BEV RNA synthesis is inhibited and BEV protein synthesis is allowed to proceed in the presence of HBB, these results support the concept that proteins play a role in the development of cytopathology independently of viral double-stranded RNA.

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Cited by 4 publications
(2 citation statements)
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“…Early studies focused on the CPE produced by poliovirus (PV) and coxsackievirus (16,33,70) and revealed crystalline arrays of virus in the cytoplasm and viruses associated with, and contained within, membrane vesicles (7,10,43). The origin of vesicles induced by PV has been the subject of several studies with various conclusions.…”
Section: Foot-and-mouth Disease Virus (Fmdv) a Member Of Thementioning
confidence: 99%
“…Early studies focused on the CPE produced by poliovirus (PV) and coxsackievirus (16,33,70) and revealed crystalline arrays of virus in the cytoplasm and viruses associated with, and contained within, membrane vesicles (7,10,43). The origin of vesicles induced by PV has been the subject of several studies with various conclusions.…”
Section: Foot-and-mouth Disease Virus (Fmdv) a Member Of Thementioning
confidence: 99%
“…The generation of the vesicles associated with the PV replication complex depends on the production of viral nonstructural proteins (8,13,39). Expression of individual viral nonstructural gene products in mammalian cells revealed that many of these proteins have multiple functions (references 6,7,30,36,45,49,66, and 69 and references therein).…”
mentioning
confidence: 99%