Bovine gamma delta T cells and the function of gamma delta T cell specific WC1 co-receptors

“…Several important agricultural species such as cattle, sheep, swine and chickens have high ␥␦ T cell numbers in circulation (Telfer and Baldwin, 2015). ␥␦ T cells comprise up to 70% of circulating T lymphocytes in the blood of bovine calves.…”

Section: Bovine ı T Cellsmentioning

confidence: 99%

“…Though much work remains to fully understand their importance, studies on bovine ␥␦ T cells have elucidated 1) antigens that drive their responses (Abrahamsen, 1998;Baldwin et al, 2002;Fikri et al, 2001Fikri et al, , 2002Mwangi et al, 2002;Naiman et al, 2001;Rhodes et al, 2001;Smyth et al, 2001), 2) their potential role in responses against pathogens including: Mycobacterium sps. (Rhodes et al, 2001;Smyth et al, 2001;Telfer and Baldwin, 2015), Cryptosporidium parvum (Abrahamsen, 1998), Cowdria ruminantium (Mwangi et al, 2002), Leptospira borgpetersenii (Naiman et al, 2001), Staphylococcus sps. (Fikri et al, 2001), Theileria parva (Daubenberger et al, 1999) Anaplasma marginale (Lahmers et al, 2006), and foot and mouth disease virus (Toka et al, 2011), 3) ligands and counter-receptors important in their activation (Ahn et al, 2002;Fikri et al, 2002;Sathiyaseelan et al, 2002;Sopp and Howard, 2001), 4) subset-specific responses (Hedges et al, 2003a;Meissner et al, 2003), and 5) the molecular basis for their unique trafficking behavior (Jones et al, 1997;Jutila and Kurk, 1996;Jutila et al, 1997;Walcheck and Jutila, 1994;Wilson et al, 1999Wilson et al, , 2002.…”

Section: Bovine ı T Cellsmentioning

confidence: 99%

Adjuvant materials that enhance bovine γδ T cell responses

Hedges

Holderness

Jutila

2016

Veterinary Immunology and Immunopathology

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Despite the availability of vaccines and antibiotics, viral, bacterial and parasite-induced intestinal and pulmonary diseases still cause significant losses to the livestock industry. Excepting improvements in calf survival due to predation, there have been only modest improvements in bovine calf survival since 1991. Strikingly, digestive and respiratory diseases still account for almost half of the non-predator deaths in calves. The innate immune system has evolved to rapidly recognize and respond to invasive microbial threats. Augmentation of innate immunity is a broad-spectrum, potent and non-specific alternative approach to effectively counter a microbial invasion. In recent years we have focused our research efforts on the development of effective and inexpensive adjuvant therapies for cattle that can be used to help mitigate infection. Unique in our approach to the development of the potential new treatments, is our focus on bovine γδ T cells, which are important lymphocytes of the innate immune system and of particular importance to ruminant immunological health. This review focuses on recent results obtained using two such adjuvant materials.

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“…CD163-L1 (M160, CD163B, encoded by CD163L1), a long tail homolog of CD163A, is a type I transmembrane molecule structurally composed of 12 SRCR domains, expressed by cells of the myeloid lineage, and may be involved in the differentiation of monocytes to macrophages. Thus far, it has only been found in the human and equine genomes (113). Two cytoplasmic splice variants of CD163-L1 have been identified thus far: the fulllength variant (CD163-L1a) with a cytoplasmic tail of 71 aa residues and the short tail variant (CD163-L1b) with 39 aa residues.…”

Section: Sr-g1 the Protein Is Currently Known As Sr-psox/cxcl16mentioning

confidence: 99%

“…The murine genome encodes two CD163c-a genes, SCART1 and SCART2, which are expressed on gd T cells, and in the lymph node, trachea, and lung. The bovine genome contains one CD163 gene and one CD163ca/SCART1 gene, which are both expressed in gd T cells, as well as peripheral blood monocytes, mesenteric lymph node, lung, and intestinal epithelial lymphocytes (113).…”

Section: Sr-g1 the Protein Is Currently Known As Sr-psox/cxcl16mentioning

confidence: 99%

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

PrabhuDas

Baldwin²,

Bollyky

et al. 2017

The Journal of Immunology

Self Cite

284

193

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Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by the United States National Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.

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Bovine gamma delta T cells and the function of gamma delta T cell specific WC1 co-receptors

Cited by 42 publications

References 120 publications

Characterization of leukocyte subsets in buffalo ( Bubalus bubalis ) with cross-reactive monoclonal antibodies specific for bovine MHC class I and class II molecules and leukocyte differentiation molecules

Characterization of leukocyte subsets in buffalo ( Bubalus bubalis ) with cross-reactive monoclonal antibodies specific for bovine MHC class I and class II molecules and leukocyte differentiation molecules

Adjuvant materials that enhance bovine γδ T cell responses

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

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