Bovine Herpesvirus 1 Invasion of Sensory Neurons by Retrograde Axonal Transport Is Dependent on the pUL37 Region 2 Effector

Abstract

A molecular and cellular understanding of the retrograde axonal transport process that underlies the neuroinvasive properties of the alphaherpesviruses is established from studies of herpes simplex virus and pseudorabies virus. The degree to which this phenotype is conserved in other related viruses has largely not been examined.

The third Japan-U.S. symposium on motor proteins and associated single-molecule biophysics

“…His team showed that the kinesin used for the latter step is not recruited from the cytoplasm during transport, but rather is incorporated and assimilated into the viral particle in a previously infected cell [ 21 ]. In his talk, he will also explain how a viral effector protein spatially and temporally regulates the assimilated kinesin motor to promote rapid intracellular trafficking of capsids to the nucleus, switching from long-distance dynein-driven transport [ 22 ].…”