Bovine herpesvirus 5 BICP0 complements the bovine herpesvirus 1 homolog

Steiner, Florian; Zumsteg, Anita; Vogt, Bernd; Ackermann, Mathias; Schwyzer, Martin

doi:10.1016/j.vetmic.2010.02.012

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…A closely related virus, bovine herpesvirus 1 (BoHV-1), expresses a protein, named bovine infected cell protein 0 (bICP0), which blocks the IFN-I signaling (Everett 2000;Saira et al 2007). BoHV-5 expresses a bICP0 homolog, and it has been recently demonstrated that bICP0 of BoHV-5 can complement its BoHV-1 homolog (Steiner et al 2010). It is, therefore, likely that the BoHV-5 bICP0 protein is able to block the host IFN-I production in the same way as its BoHV-1 counterpart.…”

Section: Introductionmentioning

confidence: 99%

The constitutive expression of the V gene of Parainfluenza virus 5 affects the growth properties of bovine herpesvirus 5

Lima

Batista

Campos

et al. 2014

Braz. arch. biol. technol.

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This study aimed to analyze the effect of the expression of Parainfluenza virus 5 (PIV5) V protein in bovine cells on the replication of Bovine herpesvirus 5 . Growth properties of BoHV-5 were evaluated in parental and PIV5 transfected cells. In one-step growth experiments, the BoHV-5 reached higher titers at earlier time points in the transfected cells when compared to the parental cells. The mean plaque size produced by the BoHV-5 in transfected cells was larger than the parental cells. This indicated that the expression of the PIV5 V gene facilitated the release and cell-to-cell spread of BoHV-5 in bovine cells.

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Section: Introductionmentioning

confidence: 99%

The constitutive expression of the V gene of Parainfluenza virus 5 affects the growth properties of bovine herpesvirus 5

Lima

Batista

Campos

et al. 2014

Braz. arch. biol. technol.

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The latency related gene of bovine herpesvirus types 1 and 5 and its modulation of cellular processes

Silvestro

Bratanich

2016

Arch Virol

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Bovine herpesvirus type 1 (BoHV-1) and bovine herpesvirus type 5 (BoHV-5) are important pathogens of cattle. The diseases they produce are quite different, with BoHV-5 being more neuropathogenic than BoHV-1 which mainly induces respiratory symptoms. The sequencing of the entire BoHV-5 genome has shown that most of the differences between these viruses are found in the immediate early and LR (latency related) genes. The LR gene is the only viral gene abundantly expressed in latently infected neurons, is essential for viral reactivation and seems to have an anti-apoptotic function which can be observed in vivo and in vitro. This gene spans two potential ORFs (1 and 2) which can also be found as a fused version, an ORF-E protein encoded within the promoter region and two miRNAs located within the 5' UTR segment. Most of the essential functions of the LR gene seem to be located within the ORF-2 which has been found to modulate components of cell signaling/cycle pathways. In this review we present a comparative sequence analysis of the LR gene of several BoHV-5 isolates, their differences with the BoHV-1 homologue and the potential impact this may have on its function. The LR gene was found to be highly conserved in all sequenced BoHV-5 strains. ORF-1 shares 60 % homology compared to BoHV-1 whereas the BoHV-5 homologue of ORF-2 is truncated at amino acid 51. Preliminary studies analyzing the emerging transcripts from the BoHV-5 LR gene in infected cells, as well as in stably transfected cells, indicates that their products are, in fact, missing crucial components of the anti-apoptotic function when compared to the BoHV-1 LR gene. In addition these transcripts maintain a region that, similar to what is found in BoHV-1, would produce a miRNA with the potential to recognize a region within the BoHV-5 immediate early gene. All together, these BoHV-5 characteristics suggest that this virus would not possess the same repertoire of latency maintaining functions as BoHV-1. Implications for BoHV-5 neuropathogenic potential are discussed.

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Bovine herpesvirus 5 BICP0 complements the bovine herpesvirus 1 homolog

Cited by 2 publications

References 23 publications

The constitutive expression of the V gene of Parainfluenza virus 5 affects the growth properties of bovine herpesvirus 5

The constitutive expression of the V gene of Parainfluenza virus 5 affects the growth properties of bovine herpesvirus 5

The latency related gene of bovine herpesvirus types 1 and 5 and its modulation of cellular processes

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