Bovine Immune Recognition of Ostertagia ostertagi Larval Antigens

Mansour, Mahmoud; Dixon, John; Clarkson, M. J.; Carter, Stuart; Rowan, T.G.; Hammet, N.C.

doi:10.1016/0165-2427(90)90006-e

Cited by 27 publications

(4 citation statements)

References 13 publications

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“…The induction of Cooperia ‐specific IgG1 after a primary infection has been described previously (30). Similar findings were reported for other gastrointestinal nematodes in ruminants such as O. ostertagi in calves (31–33) or H. contortus in sheep (16,34). However, the finding that IgG1 levels after a primary Cooperia infection enable differentiation between responder types is new.…”

Section: Discussionsupporting

confidence: 84%

Characterization of host responder types after a single Cooperia oncophora infection: kinetics of the systemic immune response

Kanobana

Vervelde

Veer

et al. 2001

Parasite Immunology

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After primary infection with 100,000 third stage larvae of the intestinal nematode Cooperia oncophora in 3-month-old calves, a high variability in egg output and worm counts is observed. Based on this variability, infected animals can be divided in different responder types. The three major phenotypes can be classified as high, intermediate and low responder animals. We investigated whether calves classified into different responder types show different immune responses during infection. Peripheral blood eosinophil counts and flow cytometric analysis of different lymphocyte subsets of the blood did not reveal major differences between infected and control animals, nor between responder types. However, the levels of Cooperia-specific immunoglobulin (Ig)G1 and IgA during primary infection were significantly higher in intermediate responders than in low responders. In the intermediate responders, isotype specific responses were negatively correlated with parasitological parameters expressing worm expulsion and influence on worm fecundity. Total serum IgE levels were elevated in most of the infected animals. A quantitative positive relationship between worm counts and total serum IgE levels was observed. Based on the observed correlations, we propose a role for the humoral response against the maintenance of the infection in the gut.

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Section: Discussionsupporting

confidence: 84%

Characterization of host responder types after a single Cooperia oncophora infection: kinetics of the systemic immune response

Kanobana

Vervelde

Veer

et al. 2001

Parasite Immunology

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“…and reached values similar to G-A levels as of the 15th w.a.p.i. It has been reported that IgG1 is the most abundant IgG subclass found during many helminthoses both in rats (Poitou et al 1993) and in cattle (Mansour et al 1990;Clery et al 1996). In contrast, Grzych et al Table 3 Egg excretion of rats infected with F. hepatica.…”

Section: Immune Responses Of Chronically Infected Rats Following a Sementioning

confidence: 86%

Subclass profile of specific IgG antibodies in rats challenged during acute and chronic primary infection with Fasciola hepatica

Paz

Sánchez-Andrade

Fontán

et al. 1999

Parasitology Research

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The influence of a previous infection (acute and chronic) on the kinetics of the immune humoral response in rats challenged with Fasciola hepatica was studied. Two infected groups were reinfected at different times--one, at 4 weeks after primary infection (w.a.p.i.); and the other, at 11 w.a.p.i. Signs of reinfection were observed in the two challenged groups as evidenced by an increment in glutamate dehydrogenase and gamma-glutamyl transpeptidase activity after secondary infection. IgG subclass (IgG1, IgG2a, IgG2b, IgG2c) responses to F. hepatica excretory/secretory products (FhESP) differed, depending on the time of challenge infection, but no difference was observed between the reinfected groups. A predominance of the IgG1 subclass was noted in the group challenged at 4 w.a.p.i., and IgG2b and IgG2c were prominent in the group reinfected at 11 w.a.p.i. These results indicate that the presence of juvenile or adult flukes in the liver at the time of challenge seems to influence the immune response to a secondary infection.

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“…In cattle, the most extensively studied GI nematode, in regards to host immune responses, is Ostertagia ostertagi. Within 3-4 weeks of experimental infection (Canals and Gasbarre, 1990;Mansour et al, 1990), and 2 months of exposure to infected pastures (Gronvold et al, 1992;Gasbarre et al, 1993;Nansen et al, 1993) previously naive calves show significant rises in anti-Ostertagia antibodies in the peripheral circulation. These antibody responses have been detectable using a wide range of parasite derived antigens, and involve all major immunoglobulin isotypes.…”

Section: Interaction Of Gi Nematodes and The Immune Systemmentioning

confidence: 99%

Role of the bovine immune system and genome in resistance to gastrointestinal nematodes

Gasbarre¹,

Leighton²,

Sonstegard³

2001

Veterinary Parasitology

119

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Gastrointestinal nematode infections of cattle remain a constraint on the efficient raising of cattle on pasture throughout the world. Most of the common genera of parasites found in cattle stimulate an effective level of protective immunity in most animals within the herd after the animals have been on pasture for several months. In contrast, cattle remain susceptible to infection by Ostertagia for many months, and immunity that actually reduces the development of newly acquired larvae is usually not evident until the animals are more than 2 years old. This prolonged susceptibility to reinfection is a major reason that this parasite remains the most economically important GI nematode in temperate regions of the world. Although, animals remain susceptible to reinfection for a prolonged period of time, there are a number of manifestations of the immune response that result in an enhanced level of herd immunity. These include a delay in the development time of the parasites, an increase in the number of larvae that undergo an inhibition in development, morphological changes in the worms, stunting of newly acquired worms, and most importantly a reduction in the number of eggs produced by the female worms. The overall result of these manifestations of immunity is a reduction in parasite transmission within the cattle herd. The immune mechanisms responsible for these different types of functional immunity remain to be defined. In general, GI nematode infections in mammals elicit very strong Th2-like responses characterized by high levels of Interleukin 4 (IL4), high levels of IgG1 and IgE antibodies, and large numbers of mast cells. In cattle, the most extensively studied GI nematode, in regards to host immune responses, is Ostertagia ostertagi. In Ostertagia infections, antigens are presented to the host in the draining lymph nodes very soon after infection, and within the first 3-4 days of infection these cells have left the nodes, entered the peripheral circulation, and have homed to tissues immediately surrounding the parasite where they become established. The immune response seen in the abomasum is in many ways are similar to that seen other mammalian hosts, with high levels of expression of IL4 in the draining lymph nodes and in lymphocytes isolated from the mucosa. But unlike a number of other systems, lymphocyte populations taken from Ostertagia infected cattle seem to be up-regulated for a number of other cytokines, most notably Interferon (IFN, implying that in Ostertagia infections, the immune response elicit is not simply a stereotypic Th2 response. In addition, effector cell populations in the tissues surrounding the parasites, are not typical, inferring the Ostertagia has evolved means to suppress or evade protective immune mechanisms. Studies have also demonstrated that the number of nematode eggs/gram (EPG) in feces of pastured cattle is strongly influenced by host genetics and that the heritability of this trait is approximately 0.30. In addition, EPG values are not "normally" distributed and a small...

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Bovine Immune Recognition of Ostertagia ostertagi Larval Antigens

Cited by 27 publications

References 13 publications

Characterization of host responder types after a single Cooperia oncophora infection: kinetics of the systemic immune response

Characterization of host responder types after a single Cooperia oncophora infection: kinetics of the systemic immune response

Subclass profile of specific IgG antibodies in rats challenged during acute and chronic primary infection with Fasciola hepatica

Role of the bovine immune system and genome in resistance to gastrointestinal nematodes

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