Bovine lactoferrin in fish culture: Current research and future directions

Luna-Castro, Sarahí; Ceballos-Olvera, Ivonne; Benavides-González, Flaviano; Blanco-Martínez, Zeferino; Sánchez-Martínez, Genaro; Vázquez‐Sauceda, María de la Luz; Garza, Mireya de la

doi:10.1111/are.15621

Cited by 4 publications

(1 citation statement)

References 76 publications

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“…An effective strategy to counteract fish intestinal inflammation is the dietary use of functional substances that exert metabolic regulation, antioxidant properties, and immune promotion [ 4 , 9 , 10 , 11 , 12 ]. Lactoferrin (LF), a glycoprotein with a molecular weight of 78–80 kDa, is rich in milk [ 13 , 14 ] and has many biological functions [ 14 , 15 , 16 ]. A previous study showed that dietary LF supplementation could enhance the growth performance of early-weaned piglets by promoting the proliferation of intestinal beneficial bacteria, such as lactic acid bacteria; inhibiting the proliferation of E .…”

Section: Introductionmentioning

confidence: 99%

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Song

Qin

et al. 2022

Metabolites

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A 56-day feeding trial was conducted to investigate the effects of dietary lactoferrin (LF) supplementation on the growth performance and intestinal health of juvenile orange-spotted groupers fed high-soybean-meal (SBM) diets. The control diet (FM) and high-soybean-meal diet (SBM60) were prepared to contain 480 g/kg protein and 110 g/kg fat. Three inclusion levels of 2, 6, and 10 g/kg LF were added into the SBM60 to prepare three diets (recorded as LF2, LF6, and LF10, respectively). The results showed that the supplementation of LF in SBM60 increased the growth rate in a dose-dependent manner. However, the feed utilization, hepatosomatic index, whole-body proximate composition, and the abundance and diversity of intestinal microbiota did not vary across the dietary treatments (p > 0.05). After the dietary intervention with LF, the contents of the intestinal malondialdehyde, endotoxin, and d-lactic acid, as well as the plasma low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and total cholesterol were lower, and the intestinal activities of the glutathione peroxidase, lipase, trypsin, and protease were higher in the LF2-LF10 groups than that in the SBM60 group (p < 0.05). The supplementation of LF in SBM60 increased the muscle layer thickness of the middle and distal intestine and the mucosal fold length of the middle intestine vs. the SBM60 diet (p < 0.05). Furthermore, the supplementation of LF in SBM60 resulted in an up-regulation of the mRNA levels for the IL-10 and TGF-β1 genes and a down-regulation of the mRNA levels of the IL-1β, IL-12, IL-8, and TNF-α genes vs. the SBM60 diet (p < 0.05). The above results showed that a dietary LF intervention improves the growth and alleviates soybean meal-induced enteritis in juvenile orange-spotted groupers. The dietary appropriate level of LF was at 5.8 g/kg, through the regression analysis of the percent weight gain against the dietary LF inclusion levels.

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Section: Introductionmentioning

confidence: 99%

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Song

Qin

et al. 2022

Metabolites

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Therapeutic uses and applications of bovine lactoferrin in aquatic animal medicine: an overview

Abdelnour

Ghazanfar²,

Abdelhamid

et al. 2023

Vet Res Commun

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Aquaculture is an important food sector throughout the globe because of its importance in ensuring the availability of nutritious and safe food for human beings. In recent years, this sector has been challenged with several obstacles especially the emergence of infectious disease outbreaks. Various treatment and control aspects, including antibiotics, antiseptics, and other anti-microbial agents, have been used to treat farmed fish and shrimp against diseases. Nonetheless, these medications have been prohibited and banned in many countries because of the development of antimicrobial-resistant bacterial strains, the accumulation of residues in the flesh of farmed fish and shrimp, and their environmental threats to aquatic ecosystems. Therefore, scientists and researchers have concentrated their research on finding natural and safe products to control disease outbreaks. From these natural products, bovine lactoferrin can be utilized as a functional feed supplement. Bovine lactoferrin is a multi-functional glycoprotein applied in various industries, like food preservation, and numerous medications, due to its non-toxic and ecological features. Recent research has proposed multiple advantages and benefits of using bovine lactoferrin in aquaculture. Reports showed its potential ability to enhance growth, reduce mortalities, regulate iron metabolism, decrease disease outbreaks, stimulate the antioxidant defense system, and recuperate the overall health conditions of the treated fish and shrimp. Besides, bovine lactoferrin can be considered as a safe antibiotic alternative and a unique therapeutic agent to decrease the negative impacts of infectious diseases. These features can be attributed to its well-known antibacterial, anti-parasitic, anti-inflammatory, immunostimulatory, and antioxidant capabilities. This literature review will highlight the implications of bovine lactoferrin in aquaculture, particularly highlighting its therapeutic features and ability to promote immunological defensive pathways in fish. The information included in this article would be valuable for further research studies to improve aquaculture’s sustainability and the functionality of aquafeeds.

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Bioactive immunostimulants as health-promoting feed additives in aquaculture: A review

Vijayaram

Sun

Zuorro

et al. 2022

Fish & Shellfish Immunology

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Bovine lactoferrin in fish culture: Current research and future directions

Cited by 4 publications

References 76 publications

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Dietary Lactoferrin Supplementation Improves Growth Performance and Intestinal Health of Juvenile Orange-Spotted Groupers (Epinephelus coioides)

Therapeutic uses and applications of bovine lactoferrin in aquatic animal medicine: an overview

Bioactive immunostimulants as health-promoting feed additives in aquaculture: A review

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