Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN

Chen, Jo-Mei; Fan, Yao-Chung; Lin, Jen‐Wei; Chen, Yiying; Hsu, Wei‐Li; Chiou, Shyan-Song

doi:10.3390/ijms18091957

Cited by 51 publications

(30 citation statements)

References 38 publications

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“…Besides defensins and cathelicidins, there are other peptides found in mammals, such as lactoferrin, a peptide derived from mammals' milk and studied for the past 30 years, which possesses various antimicrobial and immunomodulatory properties. Lactoferrin's antiviral activity has already been described against many viruses such as CMV, HSV-1, and -2, adenovirus, rotavirus, poliovirus, RSV, HIV, influenza, HCV, HBV, and, recently, bovine lactoferrin showed activity against dengue, chikungunya, and Zika viruses, all three transmitted by the Aedes aegypti mosquito [117][118][119][120]. Lactoferricin, a smaller peptide derived from the N-terminal region of lactoferrin, has also been described as an antiviral peptide.…”

Section: Avps Derived From Mammalsmentioning

confidence: 98%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

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While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence and re-emergence of viral epidemics pressure the health and scientific community to constantly find novel molecules with antiviral potential. This search involves numerous different approaches, and the use of antimicrobial peptides has presented itself as an interesting alternative. Even though the number of antimicrobial peptides with antiviral activity is still low, they already show immense potential to become pharmaceutically available antiviral drugs. Such peptides can originate from natural sources, such as those isolated from mammals and from animal venoms, or from artificial sources, when bioinformatics tools are used. This review aims to shed some light on antimicrobial peptides with antiviral activities against human viruses and update the data about the already well-known peptides that are still undergoing studies, emphasizing the most promising ones that may become medicines for clinical use.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Avps Derived From Mammalsmentioning

confidence: 98%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

View full text Add to dashboard Cite

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“…One of the most well-known characteristics of LF is that it is antibacterial (19,(144)(145)(146)(147)(148), antiviral (99,(149)(150)(151), antifungal (152)(153)(154), anti-inflammatory (26), and anti-carcinogenic (155).…”

Section: Bacteria and Lactoferrinmentioning

confidence: 99%

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

Heyden²,

2020

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Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has important immunological properties, and is both antibacterial and antiviral. In particular, there is evidence that it can bind to at least some of the receptors used by coronaviruses and thereby block their entry. Of importance are Heparan Sulfate Proteoglycans (HSPGs) and the host receptor angiotensin-converting enzyme 2 (ACE2), as based on other activities lactoferrin might prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from attaching to the host cells. Lactoferrin (and more specifically enteric-coated LF because of increased bioavailability) may consequently be of preventive and therapeutic value during the present COVID-19 pandemic.

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“…Since the increase in cholesterol levels during flavivirus infection is the consequence of an increase in cholesterol synthesis and an increase in cholesterol uptake through the LDL receptors (Soto-Acosta et al, 2013 ), it may be possible to inhibit viral infection not only inhibiting synthesis but also decreasing uptake. Recent evidence suggests that pre-treatment with bovine lactoferrin inhibits infection of all four DENV serotypes in Vero cells blocking the binding of DENV to the cell membrane by interaction with heparan sulfate, DC-SIGN, and LDLr (Chen et al, 2017 ). Bovine lactoferrin might inhibit infection with DENV or other flaviviruses by binding to potential receptors, such as LDLr.…”

Section: Cholesterol-lowering Therapy As Potential Therapeutics In Flmentioning

confidence: 99%

The Role of Host Cholesterol During Flavivirus Infection

Osuna-Ramos

Reyes-Ruiz

Ángel

2018

Front. Cell. Infect. Microbiol.

132

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In recent years the emergence and resurgence of arboviruses have generated a global health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and West Nile (WNV) virus, belong to the genus Flavivirus, cause high viremia and occasionally fatal clinical disease in humans. Given the genetic austerity of the virus, they depend on cellular factors and organelles to complete its replication. One of the cellular components required for flavivirus infection is cholesterol. Cholesterol is an abundant lipid in biomembranes of eukaryotes cells and is necessary to maintain the cellular homeostasis. Recently, it has been reported, that cholesterol is fundamental during flavivirus infection in both mammal and insect vector models. During infection with DENV, ZIKV, YFV, and WNV the modulation of levels of host-cholesterol facilitates viral entry, replicative complexes formation, assembly, egress, and control of the interferon type I response. This modulation involves changes in cholesterol uptake with the concomitant regulation of cholesterol receptors as well as changes in cholesterol synthesis related to important modifications in cellular metabolism pathways. In view of the flavivirus dependence of cholesterol and the lack of an effective anti-flaviviral treatment, this cellular lipid has been proposed as a therapeutic target to treat infection using FDA-approved cholesterol-lowering drugs. This review aims to address the dependence of cholesterol by flaviviruses as well as the basis for anti flaviviral therapy using drugs which target is cholesterol synthesis or uptake.

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Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN

Cited by 51 publications

References 38 publications

Antiviral peptides as promising therapeutic drugs

Antiviral peptides as promising therapeutic drugs

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

The Role of Host Cholesterol During Flavivirus Infection

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