Bovine leukemia viral DNA found on human breast tissue is genetically related to the cattle virus

Bovine leukemia virus detection in humans: A systematic review and meta-analysis

“…(2021) 28 Risk factor for breast cancer development under exposure to bovine leukemia virus in Colombian women: A case-control study 2021 PLoS One Colombia Olaya-Galan et al. (2021) 29 Virus de la leucosis bovina (VLB) y evidencias de su potencial zoonótico 2021 Doctoral thesis Colombia Olaya-Galán (2021) 30 Virus de la leucosis bovina: evaluación de la presencia del provirus en sangre humana y analisis in silico de los receptores celulares involucrados en su interacción 2021 Master's Thesis Colombia Velandia Álvarez (2021) 31 Bovine leukemia viral DNA found on human breast tissue is genetically related to the cattle virus 2021 One Health Brazil Canova et al. (2021) 32 Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential 2021 Int J Environ Res Public Health Colombia Corredor-Figueroa et al.…”

No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan

“…During the BLV-induced leukemia progression, BLV proviral genes coding for polymerase, capsid, and envelop proteins become increasingly deleted in BLV-infected cattle to escape from the host immune response, while BLV still retains the LTR region and tax gene, which carry oncogenic potential [ 9 , 52 , 53 ]; it is not clear whether BLV can cause the same phenomenon in human body, considering that all the blood donors are healthy. Further, although BLV proviral DNA has been independently identified in breast tissues [ 25 – 27 , 29 , 30 , 33 , 34 , 54 , 55 ], lung carcinoma [ 35 ], and blood [ 28 , 34 ], only a fragment and not the full-length BLV genome has been detected in human tissues. Therefore, in current study, we tried to amplify nine long fragments of BLV provirus as well as six short fragments corresponding of different proviral genes in human blood and breast cancer tissue samples to detect any possibly BLV-infected target specimens.…”

The Global Epidemiology of Bovine Leukemia Virus: Current Trends and Future Implications

“…Furthermore, untreated fresh milk and raw beef can contain BLV nucleic acid sequences. Although there are currently insufficient data to establish a direct link between BLV and human breast cancer, BLV gene fragments have been detected in the tumor tissues of breast cancer patients [20,21,[24][25][26]. Therefore, it is crucial to strictly test and control dairy products from BLV-positive cows to ensure food safety.…”

“…In addition to its impact on cattle herds, studies have shown that unsterilized or uncooked dairy and beef products contain proviral nucleic acid fragments of BLV, which raises concerns about public health and safety [20]. While it has not been confirmed that BLV can cause human infections, the positive detection rate of BLV in samples from breast cancer patients is significantly higher compared to healthy breast control groups [21][22][23][24][25][26]. Moreover, there is a correlation between the consumption of beef, milk, and dairy products and the incidence of breast cancer in different countries and regions.…”