Bovine nasal eosinophilic granuloma with blood eosinophilia caused by Nocardia species

Abstract

This lesion resulted from chronic infection with Nocardia sp and is distinct from other forms of bovine nasal granuloma, also called atopic rhinitis or chronic granular rhinitis, which we propose should be classified as bovine allergic granular rhinitis. The most appropriate name for the present disease is bovine nasal eosinophilic granuloma.

Histological Study of Bovine Nocardial Eosinophilic Granuloma with Comparison of Splendore-Hoeppli Material

“…As in the previously reported case (Shibahara et al 2001), eosinophil infiltration and epithelioid cells with filamentous bacterial organisms were observed in the present cases. As these organisms were positive with Gram (Nishioka's method) (Tsutsumi 2000) and Fite's acid fast stain, and included an anti-Nocardia antibody (Shibahara et al 2001), Nocardia spp.…”

“…As these organisms were positive with Gram (Nishioka's method) (Tsutsumi 2000) and Fite's acid fast stain, and included an anti-Nocardia antibody (Shibahara et al 2001), Nocardia spp. were considered the causal agents of the eosinophilic granulomas.…”

“…In a case of eosinophilic granuloma in the nasal vestibule of a Japanese Brown heifer, abundant Splendore-Hoeppli material surrounded by eosinophils was observed, and Corynebacterium ulcerans producing diphtheria toxin was isolated from the lesion (Murakami et al 2014 caused by Nocardia sp. in the nasal cavities of a Holstein heifer has also been reported (Shibahara et al 2001). Here, we describe the histology of two additional cases of bovine nocardial eosinophilic granuloma, with particular emphasis on the relation between Splendore-Hoeppli material and the inflammatory cells in certain bacterial infections.…”

“…In addition, stained sections from previously reported cases of nocardial eosinophilic granuloma (Shibahara et al 2001) and actinomycosis (Murakami et al 2014) were also observed as controls.…”

“…is histologically characterized by fungal hyphae and neutrophil infiltration, but epithelioid cell granuloma with eosinophil infiltration is formed in allergic bronchopulmonary aspergillosis in humans (Bosken et al 1988). Allergic granuloma may occur in the skin and nasal cavity of cattle (Murakami et al 2014, Riet-Correa et al 1992, Shibahara et al 2001. However, small amounts of allergens can cause severe inflammation in both humans and animals, implying difficulties in identifying its etiological agents.…”