Bovine ovarian cells have (pro)renin receptors and prorenin induces resumption of meiosis in vitro

Dau, Andressa Minussi Pereira; Silva, Eduardo Pradebon da; Rosa, Paulo Roberto Antunes da; Bastiani, Felipe T.; Gutierrez, Karina; Ilha, Gustavo Freitas; Comim, Fábio Vasconcellos; Gonçalves, Paulo Bayard Dias

doi:10.1016/j.peptides.2016.03.010

Cited by 8 publications

(3 citation statements)

References 55 publications

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“…As an enzyme located in the initiation link of RAS, renin regulates the activity of the whole system. In addition, it has been con rmed that (pro)renin can play an Ang -independent regulatory role in the meiosis of bovine oocytes [31]. Renin levels in hFF also show differently in a variety of ovarian diseases or abnormalities.…”

Section: Results In the Context Of What Is Knownmentioning

confidence: 99%

Association of the Renin-Angiotensin System Components in Human Follicular Fluid with Age, Ovarian Function and IVF Outcome: A Cross-Sectional Study

Wei

Zhou

et al. 2022

Preprint

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Background Previous studies have found that there is the local renin-angiotensin system (RAS) in human ovary, and it independently plays a regulatory role in ovarian function. Age-related reproductive aging is an inevitable process. To explore the relationship between RAS components in human follicular fluid (hFF) and age, ovarian function, so as to help clinical evaluation of oocyte quality and prediction of in vitro fertilization (IVF) outcome. Methods hFF of 139 women who received IVF simply because of their husband's factors from January 2021 to February 2022. The levels of RAS components in hFF were measured, including Renin, ACE, ACE2, AngⅡ and Ang(1–7). The correlation between age and RAS in hFF was analyzed by simple linear regression, and multivariate linear regression was used to further analyze the correlation between the RAS and IVF outcome. Results A total of 139 samples of analysable hFF were obtained in this study. It was found that there was a linear negative correlation between age and renin, ACE, AngⅡ, ACE/ACE2, AngⅡ/Ang(1–7) (Pearson's r < 0, P < 0.05), while the linear relationship with ACE2 and Ang (1–7) was not significant (P > 0.05). It was found that bFSH and bLH were correlated with age, ACE-AngⅡ-AT1/2R axis, ACE2-Ang(1–7)-MAS axis (P < 0.05), AFC was correlated with age, ACE2-Ang(1–7)-MAS axis (P < 0.05), and bAMH was only correlated with age (P < 0.01). There was no correlation between RAS and bE2, bP, bPRL, bT (P > 0.05). It was found that the number of oocyte retrieval and MⅡ maturation rate were correlated with age, renin, ACE-AngⅡ-AT1/2R axis and ACE2-Ang(1–7)-MAS axis (P < 0.05), and the rate of 2PN embryos, transplantable embryos, high-quality embryos were only correlated with age (P < 0.01). Conclusions ①The influence of age on ACE-AngⅡ-AT1/2R axis was more significant than that on ACE2-Ang(1–7)-MAS axis in hFF; ②Provides evidence that gonadotropins mediate RAS activation of local ovarian follicles; ③It is still impossible to prove the effect of RAS on steroid hormone production, at least in ovarian follicles RAS cannot affect steroid hormones in the systemic circulation; ④Age and the level of RAS components in hFF have certain clinical value in predicting the number of oocyte retrieval and the rate of MⅡ maturation.

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Section: Results In the Context Of What Is Knownmentioning

confidence: 99%

Association of the Renin-Angiotensin System Components in Human Follicular Fluid with Age, Ovarian Function and IVF Outcome: A Cross-Sectional Study

Wei

Zhou

et al. 2022

Preprint

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“…39,40 Prorenin receptor 41 Liganding the newly discovered prorenin receptor results in an angiotensin-independent induction of oocyte maturation. 42 The PRR protein was detected in all types of follicular cells and PRR mRNA was detected in cumulus cells and in the oocyte. These important observations require confirmation in humans and assessment of their clinical relevance.…”

Section: Insulin-regulated Aminopeptidasementioning

confidence: 98%

The Ovarian Renin-Angiotensin System (OVRAS): A Major Factor in Ovarian Function and Disease

2016

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This contribution summarizes the pivotal role of the ovarian renin-angiotensin system (OVRAS) in ovarian physiology and disease, with particular emphasis on human clinical implications and established translational applications. The presence of a complete OVRAS in all studied species has been known for decades. The OVRAS has major effects on follicle development/atresia and ovulation and steroid hormone secretion, that is, it is necessary for normal reproduction. It is well established that OVRAS activity is regulated by gonadotropins and depends on activation of proteases in the area of growing follicles. Angiotensin and angiotensin receptors are widely distributed in the ovarian follicle, preovulatory theca and granulosa cells, and postovulatory mural granulosa-lutein cells and regulate steroidogenesis. Molecular blockade of the OVRAS inhibits oocyte maturation and ovulation. Pathologically abnormal OVRAS function has been associated with infertility, polycystic ovarian syndrome (PCOS), ovarian hyperstimulation syndrome (OHSS), and ovarian cancer. Both hyperandrogenism in PCOS and third space fluid accumulation in OHSS have been convincingly linked to overexpression of renin and angiotensin. Blockade of angiotensin receptors is under study for the treatment of gynecologic cancer, OHSS, and PCOS. However, a full understanding of the OVRAS and translational applications is lacking. In part, this is due to the discovery in recent years of previously unknown renin-angiotensin system (RAS) components and novel functions of "classical" RAS components that remain to be integrated into translational studies; newer, more specific agents to block RAS components are available only now for such research and treatment. The need for further studies is evident.

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“…For instance, binding of prorenin to the (P)RR can promote cell growth and oocyte maturation [18]. More specifically, the (P)RR has recently been suggested to induce resumption of meiosis in oocytes [19].…”

Section: Ras and Ovary And Follicular Developmentmentioning

confidence: 99%

Role of the Renin-Angiotensin System in Healthy and Pathological Pregnancies

Pepin¹,

Dehboneh²,

Raguema³

et al. 2017

Renin-Angiotensin System - Past, Present and Future

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Introduction: Pregnancy is a physiological process that necessitates many cardiovascular and hemodynamic adaptations to ensure the survival of the foetus and well-being of the mother. The renin-angiotensin system (RAS) has been suggested as key player in many of these changes as it is critical for blood pressure control as well as fluid and salt homeostasis in the non-pregnant state. Body: Normal pregnancy is characterized by an increase in the circulating levels of prorenin, renin, angiotensinogen and angiotensin-II. However, this is coupled to a diminished endothelial sensitivity to angiotensin-II, which may explain the lack of increase in blood pressure in pregnancy. Conversely, an increase in circulating levels of aldosterone and anti-diuretic hormone during pregnancy can be observed and could contribute to the enhanced renal sodium and water reabsorption, respectively. Moreover, dysregulation of the RAS has been implicated in the development of gestational hypertensive disorders such as preeclampsia. Conclusion: The difference in the RAS effects observed during normal pregnancy may be attributable to local modifications of the RAS as well as to non-classic RAS such as the angiotensin-(1-7) axis. These adaptations may be dysregulated during preeclampsia and may contribute to the development of the disease.

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Bovine ovarian cells have (pro)renin receptors and prorenin induces resumption of meiosis in vitro

Cited by 8 publications

References 55 publications

Association of the Renin-Angiotensin System Components in Human Follicular Fluid with Age, Ovarian Function and IVF Outcome: A Cross-Sectional Study

Association of the Renin-Angiotensin System Components in Human Follicular Fluid with Age, Ovarian Function and IVF Outcome: A Cross-Sectional Study

The Ovarian Renin-Angiotensin System (OVRAS): A Major Factor in Ovarian Function and Disease

Role of the Renin-Angiotensin System in Healthy and Pathological Pregnancies

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