Bovine papillomavirus: opening new trends for comparative pathology

Costa, Rui M. Gil da; Medeiros, Rui

doi:10.1007/s00705-013-1801-9

Cited by 30 publications

(24 citation statements)

References 58 publications

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“…However, economic losses associated to BPV are not restricted to Brazil. It is estimated that BPV-associated bladder cancer has been responsible for loses of s 4 million in Azores among 2000-2006 [132] besides several other countries. Thus, global economic losses due to BPV are priceless [132].…”

Section: Oncogenic Virus and Ros Generation: A Field To Explorementioning

confidence: 99%

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Genetics and metabolic deregulation following cancer initiation: A world to explore

Araldi

Módolo

Júnior

et al. 2016

Biomedicine & Pharmacotherapy

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Section: Oncogenic Virus and Ros Generation: A Field To Explorementioning

confidence: 99%

“…Both viruses have common genetic, morphological and pathogenic characteristics [127], can be disseminated by hematology pathway [28,[128][129][130][131], turning then a public health problem [132]. Moreover, BPV is considered a study prototype of oncogenic process [133].…”

Section: Oncogenic Virus and Ros Generation: A Field To Explorementioning

confidence: 99%

Genetics and metabolic deregulation following cancer initiation: A world to explore

Araldi

Módolo

Júnior

et al. 2016

Biomedicine & Pharmacotherapy

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“…Considering that L1 is a late protein, it is expressed in the most differentiated epithelium layers (Buck et al , 2004). Therefore, L1 immunodetection has been considered the main evidence of productive infection (Nasir and Reid, 1999; Costa and Medeiros, 2014; Melo et al , 2015; Araldi et al , 2015b), which is characterized by the virus assembly (Green, 1972). …”

Section: Late Proteins: L1 and L2mentioning

confidence: 99%

“…PV-1 E5 is a transmembrane protein (Costa and Medeiros, 2014), with 43-44 amino acids, characterized by the presence of a central hydrophobic region, which acts as a transmembrane domain (Burkhardt et al , 1989; Tomita et al , 2007; DiMaio, 2014). E5 also presents two cysteine residues in the C-terminal region that confers stability for the homodimer composed by two E5 monomers (DiMaio, 2014).…”

Section: Oncogenic Proteins Expressed By Pvs: E5 E6 and E7mentioning

confidence: 99%

Papillomaviruses: a systematic review

et al. 2017

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In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome the problem, the vaccines that we have been developing involve recombinant DNA technology, aiming at prophylactic and therapeutic procedures. It is important to point out that these strategies can be used as models for innovative procedures against HPV, as this virus is the main causal agent of cervical cancer, the second most fatal cancer in women.

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“…BPV is a cosmopolitan virus, being present in all continents [1,9], leading to important economic loses worldwide [10]. About 60% of Brazilian cattle herd are infected by BPV [2].…”

Section: Introductionmentioning

confidence: 99%

Bovine papillomavirus productive infection in cell cultures: First evidences

Araldi¹,

Melo²,

Consonni³

et al. 2017

Virol Res Rev

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Bovine papillomavirus (BPV) is the etiological agent of bovine papillomatosis (BP), infectious disease, characterized by the presence of multiples papillomas that can regress spontaneously or progress to malignances. Although recognized as mutagen, BPV action following cancer initiation remains few explored, since studies about cancer progression and metastasis are based on cell cultures. The lack of attention to in vitro models is a reflection of the papillomavirus replication paradigm, which is dependent of epithelium cell differentiation. Since 2008, we have explored the potential of cell lines derived from BPV-infected neoplasms as model to study the oncogenic process. In this study, we described BPV productive infection in cell lines derived from cutaneous papilloma, fibropapilloma and esophageal carcinoma (EC) in which BPV DNA sequences were previously detected by PCR. Considering that the immunodetection of L1 capsid protein is the main evidence of productive infection, we analyzed the expression of this protein by immunofluorescence and flow cytometry. Results showed the immunodetection of L1 protein in cell lines derived from cutaneous papilloma, fibropapilloma and EC, but not in cells derived from BPV-free normal skin. We also observed the presence of spherical and electron-dense particles, with 41.02-61.94 nm diameter in cytoplasmic vesicles of cells in the sixth passage of cutaneous papilloma, fibropapilloma and EC, being compatible with the expected BPV morphology. Cells derived from BPV-free normal skin, in turn, showed membranous particles up to 75.00 nm not compatible with BPV morphology. These results suggest the BPV productive infection in cells lines derived from BPV-infected neoplasm, reinforcing that these cells are useful models to study the viral biology and pathogenesis.Correspondence to: Rita de Cassia Stocco, Genetics Laboratory, Butantan Institute, São Paulo, 05503-900, Brazil, Tel: +55 11 2627-9701; e-mail: rita. stocco@butantan.gov.br Highlights• Bovine papillomavirus (BPV) cause multiples papillomas that can regress or progress to malignances;• BPV action following cancer initiation remains few explored;• Identification of BPV L1 capsid protein and virion-like particles in cytoplasmic vesicles of cell lines derived from BPVinfected cutaneous papilloma, fibropapilloma and esophageal carcinoma;• Cell lines derived from BPV-infected neoplasm can be considered useful model to study the viral biology and pathology.

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Bovine papillomavirus: opening new trends for comparative pathology

Cited by 30 publications

References 58 publications

Genetics and metabolic deregulation following cancer initiation: A world to explore

Genetics and metabolic deregulation following cancer initiation: A world to explore

Papillomaviruses: a systematic review

Bovine papillomavirus productive infection in cell cultures: First evidences

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