Bovine peritonitis associated with <i>Mannheimia haemolytica</i> serotype 2 in a three-day-old Japanese Black calf

Abstract

A Japanese Black calf became dehydrated on the first day of life and died on the third day. Gross examination revealed a large amount of yellowish-brown serous fluid in the abdominal cavity and whitish-yellow fibrin in the serosa of the abdominal organs. Patchy red spots were observed throughout the peritoneum, and the outer membrane of the umbilical arteries was dark red. Bacteriologically, Mannheimia haemolytica serotype 2 was isolated from the umbilical arteries and vein, liver, and kidney. Histopathology revealed inflammation with M. haemolytica serotype 2 in the outer membrane of the umbilical arteries and in the serosa of the bladder and intestinal tract. This is the first case of bovine peritonitis with histopathologic and immunohistochemical identification of M. haemolytica.

RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages

“…Long-distance transportation is an essential part of the beef cattle industry, but transportation stress caused by long-distance transportation can weaken cattle’s immune systems causing the occurrence of bovine respiratory disease complex (BRDC) [ 1 ]. During the occurrence of BRDC, gram-negative bacterial infections are a major cause of pneumonia [ 2 , 3 ]. Lipopolysaccharide (LPS) and hyperglycemia were considered the most common contributors to the pulmonary inflammatory response [ 4 ].…”

The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway

“…Transportation stress also could inhibit the bovine immune system, thereby increasing the risk of gram-negative bacterial infection [1,9]. Pasteurella multocida, Mannheimia haemolytica, and Escherichia coli have been reported to trigger not only respiratory disease but also sepsis in cattle [10][11][12][13]. The kidney is one of the most vulnerable organs to hyperglycemia and sepsis [14,15].…”

Phenotypic and genotypic characterization of <i>Actinobacillus suis</i> sensu stricto isolated from a dairy calf

“…To date, 12 serovars have been identified in M. haemolytica ; serovars 1 and 6 of this organism are most frequently associated with disease in cattle, while serovar 2 is largely considered to be a commensal in the upper respiratory tract of healthy cattle [ 16 ]. In contrast, serovar 2 has also been recognized as a causative agent of ovine pneumonia [ 16 ] and a peritonitis case in a three-day-old calf in Japan [ 11 ]. The ratios of colony numbers of A. suis and M. haemolytica grown on the same CASB plate were approximately 1:1 and 1:0.03 in the right and left lungs, respectively.…”