Bovine prolactin-related protein-I is anchored to the extracellular matrix through interactions with type IV collagen

Takahashi, Toshio; Soares, Michael J.; Hashizume, Kazuyoshi

doi:10.1677/joe-07-0069

Cited by 10 publications

(4 citation statements)

References 46 publications

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“…In particular we observed a significant enrichment for GO term involved in Somatotropin and prolactin/lactogen/growth activity genes caused by a single and breed-specific CNV (chr23:33,906,415-36,330,036; three copies) that contains 12 loci (LOC751562-3, PRP1,3,4,6,9, CSH2, PRP-VII, PRL, HDGFL1, MIR2284C). These genes belongs to the PRL family (prolactin related proteins), expressed in the placenta around the first 60 days of gestation and are involved in the establishment and maintenance of pregnancy [52]. Prolactin genes (PRL) are known to have undergone rapid evolution in the lineage leading to ruminants [51-54] and to be duplicated in all well studied ruminants species.…”

Section: Resultsmentioning

confidence: 99%

Massive screening of copy number population-scale variation in Bos taurus genome

Cicconardi

Chillemi²,

Tramontano

et al. 2013

BMC Genomics

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BackgroundCopy number variations (CNVs) represent a significant source of genomic structural variation. Their length ranges from approximately one hundred to millions of base pair. Genome-wide screenings have clarified that CNVs are a ubiquitous phenomenon affecting essentially the whole genome. Although Bos taurus is one of the most important domestic animal species worldwide and one of the most studied ruminant models for metabolism, reproduction, and disease, relatively few studies have investigated CNVs in cattle and little is known about how CNVs contribute to normal phenotypic variation and to disease susceptibility in this species, compared to humans and other model organisms.ResultsHere we characterize and compare CNV profiles in 2654 animals from five dairy and beef Bos taurus breeds, using the Illumina BovineSNP50 genotyping array (54001 SNP probes). In this study we applied the two most commonly used algorithms for CNV discovery (QuantiSNP and PennCNV) and identified 4830 unique candidate CNVs belonging to 326 regions. These regions overlap with 5789 known genes, 76.7% of which are significantly co-localized with segmental duplications (SD).ConclusionsThis large scale screening significantly contributes to the enrichment of the Bos taurus CNV map, demonstrates the ubiquity, great diversity and complexity of this type of genomic variation and sets the basis for testing the influence of CNVs on Bos taurus complex functional and production traits.

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Section: Resultsmentioning

confidence: 99%

Massive screening of copy number population-scale variation in Bos taurus genome

Cicconardi

Chillemi²,

Tramontano

et al. 2013

BMC Genomics

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“…5). Various kinds of growth factors, cytokines, and hormones, such as platelet-derived growth factor (PDGF) [40], [41], hepatocyte growth factor (HGF) [42], transforming growth factor beta 1 (TGF-beta1) [43], [44], tumor necrosis factor alpha (TNF-alpha) [45], interleukin-2 (IL2) [46], interleukin-7 (IL7) [47], oncostation M (OSM) [48], and prolactin-related protein-I (PRP1) [49], bind ECM, and they may perform a pivotal role in the modulation of local bioavailability. SOLD1 may also participate in ECM remodeling.…”

Section: Discussionmentioning

confidence: 99%

Characterization and Expression Analysis of SOLD1, a Novel Member of the Retrotransposon-Derived Ly-6 Superfamily, in Bovine Placental Villi

et al. 2009

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BackgroundLy-6 superfamily members have a conserved Ly-6 domain that is defined by a distinct disulfide bonding pattern between eight or ten cysteine residues. These members are divided into membrane-type and secretory-type proteins. In the present study, we report the identification of a novel Ly-6 domain protein, secreted protein of Ly-6 domain 1 (SOLD1), from bovine placenta.Principal Findings SOLD1 mRNA was expressed in trophoblast mononucleate cells and the protein was secreted into and localized in the extracellular matrix of the mesenchyme in cotyledonary villi. SOLD1 bound mainly with type I collagen telopeptide. We confirmed secretion of SOLD1 from the basolateral surface of a bovine trophoblast cell line (BT-1). It may be related to the organization of the extra-cellular matrix in the mesenchyme of fetal villi. Since trophoblast mononucleate cells are epithelial cells, their polar organization is expected to have a crucial role in the SOLD1 secretion system. We established that SOLD1 is an intronless bovine gene containing the Alu retrotransposon, which was integrated via cytoplasmic reverse transcription.ConclusionWe identified a novel retrotransposon-like Ly-6 domain protein in bovine placenta. SOLD1 is a crucial secreted protein that is involved in the organization of the mesenchyme of the cotyledonary villi. Furthermore, the gene encoding SOLD1 has an interesting genomic structure.

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“…bPRP-I is transcribed in trophoblast binucleate cells 78 and secreted to the uterine lumen 32 . The secreted bPRP-I is deposited into the interstitial tissues of the utero-placental organ by anchoring with type IV collagen 59 . The affinity of placental PRL family proteins for extracellular matrices has also been reported in rodent d/tPRP that interacts with heparin proteoglycan 45,46 .…”

Section: Biological Rolesmentioning

confidence: 99%

Biology of the Placental Proteins in Domestic Ruminants: Expression, Proposed Roles and Practical Applications

Takahashi¹,

Hayashi²,

Hosoe³

2013

JARQ

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The female of the viviparous species gives birth to offspring capable of surviving outside the dam following a distinct gestation period. Except for monotremata, most mammals are viviparous species. Mammalian embryos dramatically develop throughout gestation in the maternal uterus and in cows in particular, life begins at fertilization at 0.2 mm in diameter, and thereafter the fetal instantaneous growth rate peaks at 350 g/day around day 220 of gestation and the fetal body weight reaches more than 35 kg at birth 43 . The fetus requires large quantities of oxygen and nutrients that cannot be sufficiently supplied by simple diffusion from the maternal endometrium. To maintain the massive fetal growth, the pregnant female forms a placenta as a lodgment for logistics between the dam and fetus. Maternal supplies come via the maternal blood, are absorbed by the placenta and then carried by the fetal blood to reach the target tissues.The gross appearance of the placenta or afterbirth varies considerably among species, such as in ruminants where the afterbirth has multiple cotyledons on the chorion, whereas other domestic species like the mare and sow form a diffused placenta consisting of a simple and diffused apposition between the fetal trophoblast and the maternal endometrium. Ruminant cotyledonary villi interdigitate to specialized projections of the caruncular tissues AbstractThe placenta, a lodgment at the feto-maternal interface, is a temporal organ that plays crucial roles in maintaining gestation and fetal development. To achieve these purposes, the placenta produces an array of proteins with distinct spatio-temporal characteristics. In this review, the authors focus on the paralog families of prolactin (PRL) and aspartic proteinase, exclusively produced by the placenta, and discuss their biological roles and practical significance in animal husbandry. The bovine placental PRL family consists of one classical member and at least ten non-classical members. Bovine placental lactogen (PL) is a unique classical member due to its lactogenic activity and potentially involved in partitioning nutrients to maintain fetal development. In contrast, the biological roles of non-classical members in bovine placental PRL family proteins remain unclear. Recent papers have reported that a non-classical member protein named prolactin-related protein -I (PRP-I) exhibited angiogenic activity following C-terminal cleavage by proteolytic enzymes. These results suggest that non-classical members of the placental PRL family exert their biological activities via specific mechanisms other than the PRL receptor-signaling pathway. The bovine genome contains a hundred or more aspartic proteinase-like genes and at least 22 mRNAs with close structural relationships are transcribed in the placenta. These molecules correspond to pregnancy-specific protein (PSP)-B, PSP-60 and pregnancy-associated glycoprotein (PAG) as reported previously. The true character of PSPs and PAG is thought to be a mixture of placental aspartic proteinase-like prote...

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Bovine prolactin-related protein-I is anchored to the extracellular matrix through interactions with type IV collagen

Cited by 10 publications

References 46 publications

Massive screening of copy number population-scale variation in Bos taurus genome

Massive screening of copy number population-scale variation in Bos taurus genome

Characterization and Expression Analysis of SOLD1, a Novel Member of the Retrotransposon-Derived Ly-6 Superfamily, in Bovine Placental Villi

Biology of the Placental Proteins in Domestic Ruminants: Expression, Proposed Roles and Practical Applications

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