Bovine Retained Placenta: Hormonal Concentrations in Fetal and Maternal Placenta

Takagi, Mitsuhiro; Fujimoto, S.; Ohtani, Masayuki; Miyamoto, Akio; Wijagunawardane, M.P.B.; Acosta, Tomás J.; Miyazawa, Keiji; Sato, Kunitada

doi:10.1053/plac.2002.0824

Cited by 46 publications

(30 citation statements)

References 58 publications

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“…Takagi et al [24] reported no group differences in the concentrations of E 1 S at the time of parturition and at 6 h after parturition. Chew et al [22] also reported no group differences for estrone and estradiol-17α, but did report decreased peripartum plasma concentrations of E 2 β in cows with RFM.…”

Section: Discussionmentioning

confidence: 95%

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

et al. 2007

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Abstract. The aim of this study was to evaluate the changes in plasma concentrations of estrone sulfate (E1S) and estradiol-17β (E2β) during the peripartum period (from day 10 prepartum to day 1 postpartum) associated with and without retention of fetal membranes (RFM) in Holstein-Friesian cattle (n=42). Plasma samples were analyzed for E1S and E2β by ELISA. All parturitions were spontaneous and normal. Of 38 cattle delivering singletons, 29 had no RFM (singleton-normal group) and nine had RFM for more than 12 h (singleton-RFM group). Four cows gave birth to twins, and each twin had its own fetal membrane (FM). Two twinning cows expelled both FMs normally within 12 h (twin-normal group). In the remaining 2 twinning cows (twin-RFM group), the FM was expelled normally for one twin (first), while the FM of the other (second) was retained. There were no significant differences in the E1S concentrations or their increments from the concentrations on the preceding day between the normal and RFM groups of singleton cows on any peripartum day. The mean plasma E2β concentrations on each day from day 10 to day 3 prepartum were significantly lower (P<0.05) in the singleton-RFM group compared with the singleton-normal group; however, on days 2 and 1 prepartum, the increments in the E2β concentrations from the concentrations on the preceding days were significantly higher (P<0.05) in the singleton-RFM group than in the singleton-normal group. Thus, the plasma E1S concentrations just before parturition may not be associated with RFM. In the cows with RFM, the lower plasma E2β concentrations that were found prior to day 2 prepartum may have been associated with immature placentomes, and the rapid rise in plasma E2β within 1 to 2 days prior to calving may have produced asynchrony of placental and/or fetal maturation in relation to calving, thus resulting in RFM.

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Section: Discussionmentioning

confidence: 95%

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

et al. 2007

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“…A total of 47 placentas were retrieved, with at least 1 placenta per experimental pen (18, 14, and 15 placentas retrieved from INR, CON, and ACC cows, respectively). All collected placentas were expelled within 12 h after calving and therefore not considered as retained fetal membranes (Takagi et al, 2002). The 5 largest cotyledons were dissected from each placenta using curved scissors, given that the largest cotyledons are expected to be the most active regarding nutrient transfer from the dam to the fetus (Senger, 2003).…”

Section: Samplingmentioning

confidence: 99%

Effects of organic or inorganic cobalt, copper, manganese, and zinc supplementation to late-gestating beef cows on productive and physiological responses of the offspring1

Marques

Cooke

Rodrigues

et al. 2016

Journal of Animal Science

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Eighty-four multiparous, nonlactating, pregnant Angus × Hereford cows were ranked by pregnancy type (56 AI and 28 natural service), BW, and BCS and allocated to 21 drylot pens at the end of their second trimester of gestation (d 0). Pens were assigned to receive forage-based diets containing 1) sulfate sources of Cu, Co, Mn, and Zn (INR); 2) an organic complexed source of Cu, Mn, Co, and Zn (AAC; Availa 4; Zinpro Corporation, Eden Prairie, MN); or 3) no supplemental Cu, Co, Mn, and Zn (CON). Diets were offered from d 0 until calving and formulated to meet requirements for energy, protein, macrominerals, Se, I, and vitamins. The INR and AAC diets provided the same daily amount of Cu, Co, Mn, and Zn. Cow BW and BCS were recorded and liver samples were collected on d -10 and 2 wk (d 75) before the calving season. Within 3 h after calving, calf BW was recorded, liver samples were collected, and the expelled placenta was retrieved ( = 47 placentas). Calves were weaned on d 283 of the experiment, preconditioned for 45 d (d 283 to 328), transferred to a growing lot on d 328, and moved to a finishing lot on d 440 where they remained until slaughter. Liver Co, Cu, and Zn concentrations on d 75 were greater ( ≤ 0.05) for INR and AAC cows compared with CON cows, whereas INR cows had reduced ( = 0.04) liver Co but greater ( = 0.03) liver Cu compared with AAC cows. In placental cotyledons, Co concentrations were greater ( ≤ 0.05) in AAC and INR cows compared with CON cows, whereas Cu concentrations were increased ( = 0.05) only in AAC cows compared with CON cows. Calves from INR and AAC cows had greater ( < 0.01) liver Co concentrations at birth compared with calves from CON cows. Liver Cu and Zn concentrations at birth were greater ( ≤ 0.05) in calves from AAC cows compared with cohorts from CON cows. Weaning BW was greater ( ≤ 0.05) in calves from AAC cows compared with cohorts from CON cows, and this difference was maintained until slaughter. In the growing lot, calves from AAC cows had reduced ( < 0.01) incidence of bovine respiratory disease compared with CON and INR cohorts. Collectively, these results suggest that feeding the AAC diet to late-gestating beef cows stimulated programming effects on postnatal offspring growth and health compared with the CON diet. Therefore, supplementing late-gestating beef cows with an organic complexed source of Co, Cu, Zn, and Mn instead of no supplementation appears to optimize offspring productivity in beef production systems.

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“…Samples of group AP were collected 12-15 days before estimated term after undisturbed gestation with an active Cl (P 4 O2 ng/ml) because a decrease in P 4 induces a significant shift in steroid secretion (Takagi et al 2002) and decreases epithelial proliferation significantly. The AP samples were Expression profiling of bovine placentomes …”

Section: Animal Model and Tissue Samplingmentioning

confidence: 99%

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes

Streyl¹,

Kenngott²,

Herbach³

et al. 2012

Reproduction

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The mechanisms underlying detachment of foetal membranes after birth in cows are still unclear. To address this problem in a systematic manner, we performed the first holistic transcriptome study of bovine placentomes antepartum (AP; nZ4 cows) and intrapartum (IP; nZ4 cows) using Affymetrix GeneChip Bovine Genome Arrays. Three placentomes were extracted from each cow, and tissue samples from the contact zones of the placentomes (foeto-maternal units) were recovered by systematic random sampling and processed for RNA extraction and for stereological quantification of cellular composition. Statistical analysis of microarray data (false discovery rate 1%) revealed 759 mRNAs with at least twofold higher levels in the samples of the AP group, whereas 514 mRNAs showed higher levels in the IP group. The differentially expressed genes were classified according to biological processes and molecular functions using the Functional Annotation Clustering tool of the DAVID Bioinformatics Resources. Genes with higher mRNA levels in the AP group were nearly completely related to mitotic cell cycle and tissue differentiation. During parturition, a complete shift occurred because the genes with higher mRNA levels in IP were nearly all related to three different physiological processes/complexes: i) apoptosis, ii) degradation of extra cellular matrix and iii) innate immune response, which play a fundamental role in placental detachment. These results are an excellent basis for future studies investigating the molecular basis of retained foetal membranes.

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Bovine Retained Placenta: Hormonal Concentrations in Fetal and Maternal Placenta

Cited by 46 publications

References 58 publications

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

Effects of organic or inorganic cobalt, copper, manganese, and zinc supplementation to late-gestating beef cows on productive and physiological responses of the offspring1

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes

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