Bovine serum albumin and insulin-dependent diabetes mellitus

Persaud, Deryck R.; Barranco-Mendoza, Alma

doi:10.1016/j.fct.2004.01.002

Cited by 29 publications

(7 citation statements)

References 30 publications

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“…Again, this view is controversial. More recent studies found no clear evidence for this hypothesis and suggest that the development of anti-BSA is part of a more general immune response against foreign proteins ( 36 – 38 ).…”

Section: Discussionmentioning

confidence: 97%

Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus

et al. 2018

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Objectives: Autoantibodies and aberrant immune complexes are pathological hallmarks of systemic lupus erythematosus (SLE). This study aimed to determine the occurrence of IgG autoantibodies against human serum albumin (anti-HSA IgG) and their potential association with antibodies against bovine serum albumin (anti-BSA IgG) in patients with SLE.Methods: Sera of 180 SLE patients included to the Swiss SLE Cohort Study and 188 age- and sex-matched healthy controls were evaluated. Levels of anti-HSA IgG and anti-BSA IgG were quantified by ELISA. Selected samples were further characterized using serum fractions obtained by fast liquid chromatography (FPLC).Results: SLE patients had increased levels of anti-HSA IgG (p = 0.002) but similar levels of anti-BSA IgG compared to matched healthy controls. Anti-HSA IgG levels correlated with the SLE Disease Activity Index (SLEDAI), which was more pronounced in patients with an physician's global assessment (PGA) of ≥ 1 (r = 0.309, p = 0.0066). Anti-HSA IgG was partially complexed with serum albumin but also occurred as monomeric autoantibodies in highly positive SLE patients. A positive correlation between anti-HSA IgG and anti-BSA IgG was found that was stronger in SLE patients than in healthy controls (r = 0.3172, p < 0.001 vs. r = 0.2122, p < 0.0035). Binding of anti-BSA IgG was inhibited partially in the presence of HSA in samples with double positivity for anti-HSA and anti-BSA (median inhibition 47.9%, range 0.9–100%) and vice versa.Conclusion: In SLE patients there is an increased prevalence of anti-HSA IgG antibodies that are associated with SLE disease activity.

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Section: Discussionmentioning

confidence: 97%

Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus

et al. 2018

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“…Aspartic acid and glutamic acid in BSA are negatively charged due to the presence of side chains with carboxylate groups. BSA also contains slightly positively charged amino acids, namely lysine and arginine [31,32]. Lysine has a side chain amino group, which can become positive by accepting a proton from water and arginine has a protonated guanidinium group.…”

Section: Discussionmentioning

confidence: 99%

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Shubhra

Tóth

Gyenis

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Lifetime prolongation for hydrophobic drug carriers has been the focus of interest for many years. Poloxamer (Pluronic F68, PF68) has been employed in this study for modifying the surface of magnetic poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with human serum albumin (HSA) model drug. Surface characteristics of untreated and PF68 treated NPs were analyzed by size, zeta potential and electrophoretic mobility studies. UV/VIS spectroscopic analysis, isothermal titration calorimetry (ITC) and dynamic light scattering methods were used to investigate serum protein (bovine serum albumin, BSA) adsorption. Results showed the successful surface attachment of PF68. Among different concentrations (0.1 to 1% wt/vol) of PF68 studied, 0.5% was found to be the most useful, since a higher concentration can issue in micelle formation. 50% less BSA tended to be adsorbed on the treated NPs in comparison to the untreated ones.

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“…It is interesting to note that up to now no clear autoimmune reaction to HSA has been proven. The role of the so-called ABBOS peptide, an epitope present on the BSA molecule, has been controversially discussed in the development of insulin-dependent diabetes mellitus (67). …”

Section: Serum Albuminsmentioning

confidence: 99%

Immune Responses to Inhalant Mammalian Allergens

et al. 2014

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In Europe and the USA, at least one person in four is exposed every day to inhalant allergens of mammalian origin, a considerable number is regularly exposed for professional reasons and almost everyone is occasionally exposed to inhalant allergens from pets or domestic animals. The production of IgE to these inhalant allergens, often complicated by asthma and rhinitis, defines the atopic status. However, the immune response to these allergens largely imprints the cellular immune compartment and also drives non-IgE humoral immune responses in the allergic and non-allergic population. During the recent years, it has become clear that IgE antibodies recognize mammalian allergens that belong to three protein or glycoprotein families: the secretoglobins, the lipocalins, and the serum albumins. In this article, we review the humoral and cellular immune responses to the major members of these families and try to define common characteristics and also distinctive features.

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Bovine serum albumin and insulin-dependent diabetes mellitus

Cited by 29 publications

References 30 publications

Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus

Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Immune Responses to Inhalant Mammalian Allergens

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