2022
DOI: 10.3390/molecules27092758
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Bovine Serum Albumin-Based Nanoparticles: Preparation, Characterization, and Antioxidant Activity Enhancement of Three Main Curcuminoids from Curcuma longa

Abstract: Bovine Serum Albumin (BSA) lipid hybrid nanoparticles are part of the new solutions to overcome low bioavailability of poor solubility drugs such as curcuminoids, which possess multiple biological advantages; however, they are counterbalanced by its short biological half-life. In this line, we prepared the three main curcuminoids: curcumin (CUR), desmethoxycurcumin (DMC), and bisdemethoxycurcumin (BDM)-loaded BSA nanoparticles. The three formulations were characterized by the average size, size distribution, c… Show more

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Cited by 10 publications
(5 citation statements)
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“…The use of plants and plant extracts is an appealing, innovative, and safe method choice. A typical ZnO-NP production process is given in Figure 3, which avoids the use of harmful and hazardous substances [40,41]. For the synthesis of ZnO-NPs, we have a variety of plants and processes at our disposal.…”
Section: Biological/green Synthesis Methodsmentioning
confidence: 99%
“…The use of plants and plant extracts is an appealing, innovative, and safe method choice. A typical ZnO-NP production process is given in Figure 3, which avoids the use of harmful and hazardous substances [40,41]. For the synthesis of ZnO-NPs, we have a variety of plants and processes at our disposal.…”
Section: Biological/green Synthesis Methodsmentioning
confidence: 99%
“…21,24 For example, Chitosantemplated Prussian blue nanoparticles showed improved effectiveness in scavenging reactive oxygen species compared to larger particles, 25 while curcuminoid-loaded bovine serum albumin nanoparticles showed significantly enhanced antioxidant activity compared to free curcuminoids in aqueous solution. 26 In this study, we prepared a molybdenum nanoparticle suspension (MNS) that reduced ROS concentrations in both the extracellular environment and cultured cells (Figure 1). In a psoriasis mouse model, MNS demonstrated the ability to alleviate psoriatic lesions and pathological manifestations while decreasing the production of important inflammatory mediators in psoriasis such as IL-17A, IL-23, IFN-γ, and TNF-α.…”
Section: Introductionmentioning
confidence: 99%
“…The nanotechnology might be an answer. When formulated into nanoscale particles, the extremely small particle size of nanomaterials brought increased surface area and enhanced adsorption, which facilitate stronger catalytic and permeation effects, along with enhanced antioxidant capabilities. , For example, Chitosan-templated Prussian blue nanoparticles showed improved effectiveness in scavenging reactive oxygen species compared to larger particles, while curcuminoid-loaded bovine serum albumin nanoparticles showed significantly enhanced antioxidant activity compared to free curcuminoids in aqueous solution . In this study, we prepared a molybdenum nanoparticle suspension (MNS) that reduced ROS concentrations in both the extracellular environment and cultured cells (Figure ).…”
Section: Introductionmentioning
confidence: 99%
“…[1] Abdelkader et at. (2022) [33] Ismail-Alhasawi (2022) [34] Fawzy et al On the other hand, an additional approach to solving the problem of poor solubility of curcuminoid-type molecules has been the discovery of new formulations, including liposomes [39,40], nanoparticles [41][42][43][44][45], or the preparation of inclusion complexes with cyclodextrins [46,47]. Beta-cyclodextrin (BCD) is the first choice [48] for the administration of drugs toward their sites of action because of its low toxicity [49], certain hydrophilicity [50], and adequate cavity.…”
Section: Introductionmentioning
confidence: 99%