Bovine Serum Albumin-Coated Ceria Nanoparticles Activate the TGF-β Signaling Pathway for Periodontal Bone Regeneration

Meng, Xiang; Wu, Tiangang; Jiang, Lei; Liu, Chang; Wang, Yuerong; Zhou, Zihan; Zhang, Yanru; Gu, Mengyun; Lu, Daru; Zhang, Lei

doi:10.1021/acsanm.3c00067

Cited by 3 publications

(3 citation statements)

References 72 publications

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“…The nanocomposite system exhibited efficient osteogenic differentiation to repair and regenerate defective periodontal bone tissue. They have reported that cerium oxide-based nanocomposite systems would be excellent materials for bone tissue engineering …”

Section: Applications Of Protein In Bone Tissue Engineeringmentioning

confidence: 99%

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, and interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs and regenerates fractured bones. Bone is a multihierarchical complex structure, and it performs several essential biofunctions, including maintaining mineral balance and structural support and protecting soft organs. Protein-based polymers have gained interest in developing ideal scaffolds as emerging biomaterials for bone fractured healing and regeneration, and it is challenging to design ideal bone substitutes as perfect biomaterials. Several protein-based polymers, including collagen, keratin, gelatin, serum albumin, etc., are potential materials due to their inherent cytocompatibility, controlled biodegradability, high biofunctionalization, and tunable mechanical characteristics. While numerous studies have indicated the encouraging possibilities of proteins in BTE, there are still major challenges concerning their biodegradability, stability in physiological conditions, and continuous release of growth factors and bioactive molecules. Robust scaffolds derived from proteins can be used to replace broken or diseased bone with a biocompatible substitute; proteins, being biopolymers, provide excellent scaffolds for bone tissue engineering. Herein, recent developments in protein polymers for cutting-edge bone tissue engineering are addressed in this review within 3−5 years, with a focus on the significant challenges and future perspectives. The first section discusses the structural fundamentals of bone anatomy and ideal scaffolds, and the second section describes the fabrication techniques of scaffolds. The third section highlights the importance of proteins and their applications in BTE. Hence, the recent development of protein polymers for state-of-the-art bone tissue engineering has been discussed, highlighting the significant challenges and future perspectives.

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Section: Applications Of Protein In Bone Tissue Engineeringmentioning

confidence: 99%

“…(D) The proposed nanocomposite system via TGF-β signaling pathway and autophagy activation for periodontal bone repair and regeneration. (Reproduced with permission from ref , Copyright 2023, American Chemical Society. )…”

Section: Applications Of Protein In Bone Tissue Engineeringmentioning

confidence: 99%

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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“…Both the excellent targeting properties and superior biosafety of appropriately modified nanoparticles are advantageous for regulating autophagy. , Nucleic acid inducers (NucA, AS1411) are small oligonucleotide fragments that are the first anticancer aptamers to be tested in clinical trials (phase I and II clinical trials). , NucA has been widely employed as a tumor-targeting agent that can be conjugated into a wide variety of molecules and nanomaterials. − NucA normally interacts with nucleolar proteins in the nucleus, but nucleolar proteins are also expressed on the surface of cancer cells . Therefore, NucA could be used as a new avenue to develop a targeted nanotherapeutic platform for ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Zhu,

Hu,

Yang

et al. 2024

ACS Appl. Nano Mater.

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Chemotherapy resistance is a major cause of the high mortality in ovarian cancer. Therefore, there is an urgent need to develop strategies to increase the sensitivity of ovarian cancer to chemotherapeutic medicines. Here, we synthesized nucleic acid aptamer (NucA)-modified zinc ferrite nanoparticles (NAZs), to induce pro-death autophagy for enhancing the sensitivity of ovarian cancer cells to the chemotherapeutic agent�cisplatin (DDP). First, we verified that zinc ferrite nanoparticles (ZFONPs) effectively induced intact cellular autophagy in SKOV3 cells. Moreover, the use of small-molecule autophagy inhibitors markedly curtailed cell death induced by ZFONPs. Notably, we found that ZFONPs-induced pro-death autophagy was mediated by increasing zinc ion release and thereby intracellular reactive oxygen species (ROS) production. Second, we demonstrated that the modification of ZFONPs with the tumor-targeting aptamer (NucA) endowed the nanoparticles with the ability to target tumor cells. Furthermore, the induction of deathpromoting autophagy by NAZs sensitized ovarian cancer cells to DDP chemotherapy. Significantly, the constructed NAZs exhibited ovarian cancer targeting capabilities, served as T 2 -weighted magnetic resonance imaging (MRI) contrast agents, and enhanced the therapeutic effect of DDP in both in vitro and in vivo experiments. Collectively, these findings present a promising and effective approach for the precise treatment and diagnosis of ovarian cancer.

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Albumin nanoparticles are a promising drug delivery system in dentistry

Kiarashi,

Yasamineh

2024

BioMed Eng OnLine

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Periodontal infection is a long-lasting inflammatory condition caused by the growth and development of an abnormal and harmful community of microorganisms. This destructive illness leads to the loss of the tissues that support the teeth, degradation of the bone surrounding the teeth, and eventually tooth loss. To treat oral infections, it is necessary to use nonsurgical methods such as antibiotics. However, the indiscriminate and incorrect use of antibiotics results in drug resistance. Among these alternate therapeutic options, using nanoparticles to treat infectious dental disease was particularly significant. Consequently, researchers have worked to develop an effective and satisfactory drug delivery method for treating periodontal and dental illnesses. Albumin nanoparticles serve a considerable function as carriers in the drug delivery of chemical and biomolecular medications, such as anticancer treatments; they have several advantages, including biocompatibility and biodegradability, and they are well-tolerated with no adverse effects. Albumin nanoparticles have several benefits over other nanomaterials. Protein nanocarriers provide advantages such as biocompatibility, biodegradability, reduced immunogenicity, and lower cytotoxicity. Furthermore, this nanoparticle demonstrated significant intrinsic antibacterial properties without being loaded with antibiotic medicines. As a medication and antibacterial nanoparticle delivery method, albumin nanoparticles have substantial applications in periodontal and dental infectious disorders such as periodontal infection, apical periodontitis, and peri-implantitis. As a result, in this article, we studied the usage of albumin nanoparticles in dental disorders. Graphical Abstract

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Bovine Serum Albumin-Coated Ceria Nanoparticles Activate the TGF-β Signaling Pathway for Periodontal Bone Regeneration

Cited by 3 publications

References 72 publications

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Albumin nanoparticles are a promising drug delivery system in dentistry

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