Bovine serum albumin–glutaraldehyde (BioGlue®) tissue adhesive versus standard renorrhaphy following renal mass enucleation: a retrospective comparison

Bahouth, Zaher; Moskovitz, Boaz; Halachmi, Sarel; Nativ, Ofer

doi:10.1177/1756287217697662

Cited by 19 publications

(28 citation statements)

References 18 publications

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“…Second, although not statistically significant on multivariate analysis, the use of the tissue adhesive (BioGlue R ) instead of sutures was shown to play a protective role against AKI on univariate analysis. This could be attributed to the advantages of using tissue adhesive including shorter ischemia time and less viable tissue loss during tumor bed closure, as we showed in a previous study [20].…”

Section: Discussionmentioning

confidence: 52%

Relationship Between Clinical Factors and the Occurrence of Post-Operative Acute Kidney Injury in Patients Undergoing Nephron-Sparing Surgery

2018

J Mol Clin Med.

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Nephron-sparing surgery (NSS) is a very common urological procedure performed for clinically localized renal tumors. Compared to radical nephrectomy, it is associated with better renal function preservation and has similar oncologic safety, but with higher complications rate. One of the most important complications is the occurrence of post-operative acute kidney injury (AKI), which has the potential to affect long-term renal function. To study the clinical factors that affect post-NSS renal function and put the patients at risk for AKI. From our NSS cohort, we analyzed the clinical and surgical data of 464 patients who were divided into AKI and non-AKI group. Patients with solitary kidney were excluded. Renal function was assessed using serum Creatinine (sCr) and estimated glomerular filtration rate (eGFR) that was evaluated using the MDRD equation. SCr was assessed daily starting one day before surgery and until the patient was discharged (usually on post-operative day 3). AKI was defined using AKIN and RIFLE criteria. Appropriate statistical analyses were undertaken to compare between the different groups. Of 464 patients, 183 (39.4%) developed AKI following surgery. The AKI patients were more likely to be of male gender (72% vs 58%, p = 0.003), and suffered more from cardiovascular diseases, including hypertension (66.1% vs 52.6%, p = 0.007), ischemic heart disease (24.6% vs 16.3%, p = 0.04) and diabetes mellitus (20.7% vs 13.8%, p = 0.04). Statistically significant differences between the groups in surgical parameters included longer average ischemia time (26 min vs 23.3 min, p = 0.004), higher mean blood loss (153 mL vs 85 mL, p = 0.01), higher transfusion rate (7.1% vs 2.1%, p = 0.01) and the use of tissue adhesive rather than conventional sutures for tumor bed closure, which had a protective effect from AKI. Multivariate analysis showed longer ischemia time, baseline chronic kidney disease and male gender to be the most important and independent risk factors for developing AKI. The most important predictors of AKI are ischemia time, baseline chronic kidney disease and male gender. Of these factors, ischemia time is the only modifiable factor, and hence should be kept to the shortest time possible.

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Section: Discussionmentioning

confidence: 52%

Relationship Between Clinical Factors and the Occurrence of Post-Operative Acute Kidney Injury in Patients Undergoing Nephron-Sparing Surgery

2018

J Mol Clin Med.

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“…Bioreactors will add a significant volume (50-2000 L) HSA extracted from the crew could have some other beneficial applications besides habitat construction. BSA is currently employed as a tissue adhesive, [64] so it is likely that HSA could be employed in an analogous manor. HSA could also be re-introduced into crew members via intravenous (IV) therapy to treat a variety of clinical conditions, including restoration of blood volume, treatment of shock, acute burns and other conditions associated with hypervolemia.…”

Section: Discussionmentioning

confidence: 99%

Blood, Sweat and Tears: Extraterrestrial Regolith Biocomposites with in Vivo Binders

Roberts

Whittall²,

Breitling³

et al. 2021

Preprint

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In this work, we explore the use of human serum albumin (HSA) – a common protein obtained from blood plasma – as a binder for simulated Lunar and Martian regolith to produce so-called extraterrestrial regolith biocomposites (ERBs). In essence, HSA produced by astronauts in vivo could be extracted on a semi-continuous basis and combined with Lunar or Martian regolith to produce a concrete-like material. Employing a simple fabrication strategy, HSA-based ERBs were produced and displayed compressive strengths as high as 25.0 MPa. For comparison, standard concrete typically has a compressive strength ranging between 20 and 32 MPa. The incorporation of urea – which could be extracted from the urine, sweat or tears of astronauts – could further increase the compressive strength by over 300% in some instances, with the best-performing formulation having an average compressive strength of 39.7 MPa. Furthermore, we demonstrate that HSA-ERBs can be 3D-printed, opening up an interesting potential avenue for extraterrestrial construction using human-derived feedstocks. The mechanism of adhesion was investigated and attributed to the dehydration-induced reorganisation of the protein secondary structure into a densely hydrogen-bonded, supramolecular β-sheet network – analogous to the cohesion mechanism of spider silk. For comparison, synthetic spider silk and bovine serum albumin (BSA) were also investigated as regolith binders – which could also feasibly be produced on a Martian colony with future advancements in biomanufacturing technology.

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“…53 Renorrhaphy techniques using tissue adhesive sealant have also been described and have demonstrated favorable reductions in warm ischemia time and blood loss with use of bovine serum albumin-glutaraldehyde (BioGlue ® , CryoLife, Inc, Kennesaw, GA, USA). 54 A subsequent study assessing renal function via DMSA scan among patients undergoing PN revealed decreased volume loss by approximately 50% with use of the tissue adhesive compared with standard suture renorrhaphy. 55 Takagi and colleagues compared monopolar coagulation of hemorrhagic areas and a tissue-sealing sheet (TachoSil ® , Baxter Healthcare, Deerfield, IL, USA) versus standard renorrhaphy.…”

Section: Renorrhaphymentioning

confidence: 99%

Optimization of renal function preservation during robotic partial nephrectomy

Swavely

Anele

Porpiglia

et al. 2019

Therapeutic Advances in Urology

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Over the past few years, the role of robotic-assisted partial nephrectomy (RPN) has exponentially grown. Multiple recognized factors contribute to postoperative renal function in patients undergoing RPN. The aim of this review is to identify these potential factors, and to evaluate strategies that may help optimize the goal of renal function preservation. A nonsystematic literature review was performed to retrieve the most recent evidence on factors contributing to renal function post-RPN. Analyzed elements include baseline factors (tumor complexity and patient characteristics), intraoperative (surgical) factors (control of the renal hilum and type of ischemia, resection technique, renorrhaphy technique), and pharmacotherapeutics. In conclusion, the advantages of robotic surgery in the setting of partial nephrectomy (PN) are becoming well established. Maximal preservation of renal function remains a priority goal of the procedure, and it is influenced by a plethora of factors. Adequate patient selection using radiomics, control of comorbidities, utilization of evidence-based intraoperative techniques/strategies, and postoperative care are key components of postoperative preservation of renal function. Further investigations regarding these factors and their effects on long-term renal function are necessary and will continue to aid in guiding appropriate patient care.

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Bovine serum albumin–glutaraldehyde (BioGlue^®) tissue adhesive versus standard renorrhaphy following renal mass enucleation: a retrospective comparison

Cited by 19 publications

References 18 publications

Relationship Between Clinical Factors and the Occurrence of Post-Operative Acute Kidney Injury in Patients Undergoing Nephron-Sparing Surgery

Relationship Between Clinical Factors and the Occurrence of Post-Operative Acute Kidney Injury in Patients Undergoing Nephron-Sparing Surgery

Blood, Sweat and Tears: Extraterrestrial Regolith Biocomposites with in Vivo Binders

Optimization of renal function preservation during robotic partial nephrectomy

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