Bovine serum albumin interactions with metal complexes

Abstract

The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.

Pt and Ti Complexes Immobilized onto Mesoporous Silica Microspheres and Their Interaction with Molecules of Biological Interest

“…In order to obtain extra information, a similar study was conducted in the presence of a bovine serum albumin solution (BSA). One of the most important properties of albumins is that they bind to different compounds in a reversible manner, often increasing the apparent solubility of hydrophobic drugs in the plasma which influences the circulation, metabolism and efficacy of drugs . Previous works have demonstrated the utility of mesoporous solids as BSA carriers.…”

New bimetallic palladium(ii) and platinum(ii) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity

“…24 In this study we synthesized two new bimetallic complexes of palladium(II) and The mechanism of interaction of transition metal complexes with serum albumin is crucial since the nature and strength of these interactions have a great influence on drug absorption, distribution, metabolism and excretion.…”

The solvent‐free synthesis of polysubstituted pyrroles by a reusable copper Schiff base complex immobilized on silica coated Fe3O4, and DNA binding study of one resulting derivative as a potential anticancer drug

“…The investigation on the interaction of a new compound with DNA is very important for the design of new drugs . Generally, the mechanism of interactions between compounds and DNA includes a series of interactions, such as hydrogen bonding, van der Waals interactions, π‐stacking interactions of aromatic heterocyclic groups between base pairs and electrostatic interactions . The most common and effective technique used to study the interaction between DNA and compounds is the UV–Vis absorption spectroscopy.…”