Bovine spastic paresis: A review of the genetic background and perspectives for the future

Goeckmann, Victoria; Međugorac, Ivica

doi:10.1016/j.tvjl.2016.07.001

Cited by 10 publications

(21 citation statements)

References 33 publications

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“…Thus, the underlying genetic condition is spread far over cattle populations and relevance for animal welfare and economics is continuously growing. The prevalence for BSS is frequently assumed to be <5% (Goeckmann et al, 2018) and for late-onset BSP lower than 1% (Goeckmann et al, 2016). However, quite obviously, these frequencies are underestimated due to the late onset of the disease symptoms and the noticeably decreased life span most cattle experience in today's dairy production.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of symptomatic animals is aged 3-7 years. Higher incidence is assumed for male cattle with an increasing prevalence of BSS within the last five decades (De Vlamynck et al, 2014;Goeckmann et al, 2016). There are clinical reports of BSS in Holstein and at least five other breeds, but BSS occurrence was expected in all cattle breeds already in the early 1950s (Roberts, 1953;Goeckmann et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…First, symptoms can originate from suboptimal husbandry conditions (e.g., hypocalcemia, claw disorders) and therefore offer curative treatment options. Second, symptoms can also indicate the late-onset form of bovine spastic paresis (BSP) (Goeckmann et al, 2016). BSS and BSP could also be two different forms of the same genetic syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…BSS and BSP could also be two different forms of the same genetic syndrome. BSP was first reported in 1922 as isolated contraction of the gastrocnemius muscle and later also categorized as a central nervous syndrome (Hamoir, 1922;Goeckmann et al, 2016). A very frequently used sire (born in 1998) is suspicious to pass on BSP.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a genome-wide association study in the North American Holstein population showed associations of BSS on bovine chromosomes 7 and 9 and therefore support the hypothesis of an autosomal inheritance (Neustaeter et al, 2015). Estimates of the disease prevalence vary but are usually lower than 5% (Neustaeter et al, 2015;Goeckmann et al, 2016Goeckmann et al, , 2018. An increasing degree of inbreeding might exert a major influence on BSS/late-onset BSP prevalence in the future (Gentile and Testoni, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires

et al. 2020

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Since their first description almost 100 years ago, bovine spastic paresis (BSP) and bovine spastic syndrome (BSS) are assumed to be inherited neuronal-progressive diseases in cattle. Affected animals are characterized by (frequent) spasms primarily located in the hind limbs, accompanied by severe pain symptoms and reduced vigor, thus initiating premature slaughter or euthanasia. Due to the late onset of BSP and BSS and the massively decreased lifespan of modern cattle, the importance of these diseases is underestimated. In the present study, BSP/BSS-affected German Holstein breeding sires from artificial insemination centers were collected and pedigree analysis, genome-wide association studies, whole genome resequencing, protein–protein interaction network analysis, and protein-homology modeling were performed to elucidate the genetic background. The analysis of 46 affected and 213 control cattle revealed four significantly associated positions on chromosome 15 (BTA15), i.e., AC_000172.1:g.83465449A>G (–log10P = 19.17), AC_000172.1:g.81871849C>T (–log10P = 8.31), AC_000172.1:g.81872621A>T (–log10P = 6.81), and AC_000172.1:g.81872661G>C (–log10P = 6.42). Two additional loci were significantly associated located on BTA8 and BTA19, i.e., AC_000165.1:g.71177788T>C and AC_000176.1:g.30140977T>G, respectively. Whole genome resequencing of five affected individuals and six unaffected relatives (two fathers, two mothers, a half sibling, and a full sibling) belonging to three different not directly related families was performed. After filtering, a homozygous loss of function variant was identified in the affected cattle, causing a frameshift in the so far unknown gene locus LOC100848076 encoding an adenosine-A1-receptor homolog. An allele frequency of the variant of 0.74 was determined in 3,093 samples of the 1000 Bull Genomes Project.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires

et al. 2020

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Congenital, familial, and genetic disorders

2022

Large Animal Neurology

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A modified tenectomy approach to a case of spastic paresis in a 10‐month‐old bullock

McFarland

Woods

Macrae

et al. 2023

Vet Record Case Reports

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Although treatment of bovine spastic paresis cases is often performed using a tibial neurectomy, the potential for substantial economic loss in an older animal, cost of anaesthesia and heightened difficulty of the procedure can preclude its use in veterinary practice. This report describes a tenectomy performed on a 450 kg bullock that presented with spastic paresis of the left hindlimb. Tenectomy of the medial and lateral tendons of the gastrocnemius muscle provided a good surgical treatment option through a modified incision site in a cranio‐lateral approach. Tenectomy has the advantages of being less invasive than neurectomy, with clearly identifiable landmarks. A key aspect in achieving a successful outcome is to preserve the superficial digital flexor tendon. In the experience of the authors, when compared to tibial neurectomy in similar sized animals, tenectomy had a reduced surgical time and minimised potential complications such as dropping of the hock.

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Bovine spastic paresis: A review of the genetic background and perspectives for the future

Cited by 10 publications

References 33 publications

Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires

Frameshift Variant in Novel Adenosine-A1-Receptor Homolog Associated With Bovine Spastic Syndrome/Late-Onset Bovine Spastic Paresis in Holstein Sires

Congenital, familial, and genetic disorders

A modified tenectomy approach to a case of spastic paresis in a 10‐month‐old bullock

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