Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models

Rhijn, Ildiko Van; Godfroid, Jacques; Michel, Anita Luise; Rutten, Victor P.M.G.

doi:10.1016/j.micinf.2008.04.005

Cited by 65 publications

(60 citation statements)

References 35 publications

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“…Bovine TB parallels human TB in several aspects of disease pathogenesis and the development of innate and adaptive immune responses (3,4). In particular, the M. bovis-specific gd T cell response is uniquely similar to that described in human TB patients (3,4). Thus, the study of virulent M. bovis infection in cattle both increases our understanding of the bovine immune response to TB and represents an excellent model for understanding M. tuberculosis infection in humans.…”

mentioning

confidence: 94%

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

McGill

Sacco

Baldwin

et al. 2014

The Journal of Immunology

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Promoting effective immunity to Mycobacterium bovis infection is a challenge that is of interest to the fields of human and animal medicine alike. We report that γδ T cells from virulent M. bovis–infected cattle respond specifically and directly to complex, protein, and nonprotein mycobacterial Ags. Importantly, to our knowledge, we demonstrate for the first time that bovine γδ T cells specifically recognize peptide Ags derived from the mycobacterial protein complex ESAT6:CFP10 and that this recognition requires direct contact with APCs and signaling through the T cell Ag receptor but is independent of MHC class I or II. Furthermore, we show that M. bovis infection in cattle induces robust IL-17A protein responses. Interestingly, in contrast to results from mice, bovine CD4 T cells, and not γδ T cells, are the predominant source of this critical proinflammatory mediator. Bovine γδ T cells are divided into subsets based upon their expression of Workshop Cluster 1 (WC1), and we demonstrate that the M. bovis–specific γδ T cell response is composed of a heterogeneous mix of WC1-expressing populations, with the serologically defined WC1.1+ and WC1.2+ subsets responding in vitro to mycobacterial Ags and accumulating in the lesions of M. bovis–infected animals. The results described in this article enhance our understanding of γδ T cell biology and, because virulent M. bovis infection of cattle represents an excellent model of tuberculosis in humans, contribute to our overall understanding of the role of γδ T cells in the mycobacterial-specific immune response.

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confidence: 94%

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

McGill

Sacco

Baldwin

et al. 2014

The Journal of Immunology

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“…This classification acknowledges the existence of one type, the focal type, that would represent an infectious state similar to that of latency that is considered the most frequent in human tuberculosis (Flynn & Chan, 2001;Corbett et al, 2003), but that has not been well def ined in cattle mycobacteriosis (Cassidy, 2006;Van Rhijn et al, 2008). Indeed, other terms representing that concept but with a broader and more epidemiological perspective, have been defined by Nielsen & Toft (2008) as: free of infection, infected (non-shedders), infectious (MAP shedders) and affected (clinical PTB and MAP shedding).…”

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confidence: 99%

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Vázquez¹,

Garrido²,

Molina³

et al. 2014

Span. j. agric. res.

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Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031 slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals.

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“…Mycobacterial infections of cattle provide good models for human tuberculosis (13)(14)(15). Cattle are within the natural host range of several pathogenic mycobacteria (M. bovis, M. tuberculosis, and M. avium subsp.…”

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confidence: 99%

Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host

et al. 2013

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The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.

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Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models

Cited by 65 publications

References 35 publications

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with VirulentMycobacterium bovis

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host

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