Bovine Tuberculosis in Buffaloes, Southern Africa

Garine‐Wichatitsky, Michel De; Caron, Alexandre; Gomo, Calvin; Foggin, Chris; Dutlow, Keith; Pfukenyi, Davies M.; Mitchell, Emily; Bel, Sébastien Le; Hofmeyr, Markus; Hlokwe, Tiny Motlatso; Michel, Anita Luise

doi:10.3201/eid1605.090710

Cited by 57 publications

(57 citation statements)

References 7 publications

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“…The information collated in this review confirms that bTB is widespread in livestock on the African continent [32], whereas bTB infection of wildlife, which was historically limited to a few countries in southern and eastern Africa (South Africa, Tanzania, Uganda, Zambia) may be spreading in southern Africa (Mozambique [30], Zimbabwe [37]). Although the impact of bTB may be significant in Africa, affecting the economy, the ecosystem and human health [28], wildlife TB is currently not considered a priority for most African countries.…”

Section: Conclusion Knowledge Gaps and The Way Forwardsupporting

confidence: 59%

A review of bovine tuberculosis at the wildlife–livestock–human interface in sub-Saharan Africa

et al. 2013

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SUMMARYInfection of wild animals by bovine tuberculosis (bTB) is raising concern worldwide. This article reviews the current epidemiological situation, risk of emergence and control options at the wildlife-livestock-human interface in sub-Saharan Africa. In livestock, bTB has been confirmed in the majority of countries from all parts of the continent. Wildlife infection is confirmed in seven countries from southern and eastern Africa, apparently spreading in the southern Africa region. Mycobacterium bovis has been isolated from 17 wild mammal species, although only four are suspected to play a role as maintenance host. Zoonotic risks are a concern, but no direct spillover from wildlife to humans has been documented, and no case of bTB spillback from wildlife to livestock has been confirmed. In this paper we assess the main risk factors of bTB spillover at the wildlife-livestock-human interface and suggest several research themes which could improve the control of the disease in the African context.

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Section: Conclusion Knowledge Gaps and The Way Forwardsupporting

confidence: 59%

A review of bovine tuberculosis at the wildlife–livestock–human interface in sub-Saharan Africa

et al. 2013

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“…Buffalo are also suspected of playing a role in the epidemiology of Rift Valley fever (5). In 2009, a bTB strain related to the strain occurring in buffalo in northern Kruger NP was detected in buffalo in Gonarezhou NP, suggesting a recent spread from Kruger NP in South Africa to Gonarezhou NP in Zimbabwe (6). Although possible explanations were proposed for this transfrontier spread, including direct transmission from buffalo to buffalo or from an unidentified wild or domestic ungulate species to buffalo (6), these modes of transmission were not supported by firm data.…”

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confidence: 83%

African Buffalo Movement and Zoonotic Disease Risk across Transfrontier Conservation Areas, Southern Africa

Caron¹,

Cornélis²,

Foggin³

et al. 2016

Emerg. Infect. Dis.

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“…Among wildlife species, buffalos are known to be one of the main wildlife reservoirs for diseases (Rodwell et al, 2001). Since buffalo are closely related to cattle, and may transmit disease directly or indirectly, buffalo also represent an important threat for the African livestock industry, from a conservation, sanitary and economic point of view (Garine-Wichatitsky et al, 2010;Jolles et al, 2005;Michel et al, 2006). For fine scale inference, a larger number of SNPs may be required, as the information content of one SNP is less than that of one microsatellite (i.e., bi-allelic vs. multi-allelic markers).…”

Section: Utility Of Snps In African Buffalomentioning

confidence: 99%

Genome-wide single nucleotide polymorphism (SNP) identification and characterization in a non-model organism, the African buffalo (Syncerus caffer), using next generation sequencing

et al. 2016

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a b s t r a c tThis study aimed to develop a set of SNP markers with high resolution and accuracy within the African buffalo. Such a set can be used, among others, to depict subtle population genetic structure for a better understanding of buffalo population dynamics. In total, 18.5 million DNA sequences of 76 bp were generated by next generation sequencing on an Illumina Genome Analyzer II from a reduced representation library using DNA from a panel of 13 African buffalo representative of the four subspecies. We identified 2534 SNPs with high confidence within the panel by aligning the short sequences to the cattle genome (Bos taurus). The average sequencing depth of the complete aligned set of reads was estimated at 5x, and at 13x when only considering the final set of putative SNPs that passed the filtering criterion. Our set of SNPs was validated by PCR amplification and Sanger sequencing of 15 SNPs. Of these 15 SNPs, 14 amplified successfully and 13 were shown to be polymorphic (success rate: 87%). The fidelity of the identified set of SNPs and potential future applications are finally discussed.

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Bovine Tuberculosis in Buffaloes, Southern Africa

Cited by 57 publications

References 7 publications

A review of bovine tuberculosis at the wildlife–livestock–human interface in sub-Saharan Africa

A review of bovine tuberculosis at the wildlife–livestock–human interface in sub-Saharan Africa

African Buffalo Movement and Zoonotic Disease Risk across Transfrontier Conservation Areas, Southern Africa

Genome-wide single nucleotide polymorphism (SNP) identification and characterization in a non-model organism, the African buffalo (Syncerus caffer), using next generation sequencing

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