BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats

In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro

“…A corresponding autotomy counteraction appears in the L2-L3 spinal compression model, when the stable gastric pentadecapeptide BPC 157 improves the healing course of the spinal cord injury and leads to functional recovery in rats [79]. Also, much like lidocaine-induced arrhythmias, BPC 157 counteracts disturbances after bupivacaine [14], KCl overdose [15], digitalis overdose [16], hypoxia and reoxygenation [17], succinylcholine [18] neuroleptics and prokinetics [19], and doxorubicin [80]. As mentioned, much like lidocaine-induced adverse effects, BPC 157 counteracts morphine-induced analgesia [26] and counteracts NSAID-induced toxicity [7,24,[27][28][29][30][31][32][33][34].…”

“…Specific arguments to extend the use of BPC 157 against the adverse effects of local anesthetics, such as lidocaine, follow the BPC 157 counteraction of bupivacaine cardiotoxicity [14], bupivacaine-induced depolarisation in HEK293 cells [14], and drug-induced heart arrhythmias [15][16][17][18][19]. A similar generalization was already made with dopamine neuroleptics or prokinetics since BPC 157 counteracts the prolongation of the QTc interval after the daily administration of dopamine neuroleptics or prokinetics [19] much like neuroleptic-induced catalepsy and gastric ulcers [19][20][21][22]. Likely, a particular extended BPC 157's beneficial effect may combine the antagonism of the entire spectrum of local anesthetic-induced neurotoxic and cardiotoxic effects.…”

“…us, we attempt to counteract lidocaine toxicity. Previously reported effective dose regimens of the pentadecapeptide BPC 157 [14][15][16][17][18][19], along with the NOS-inhibitor L-NAME and the NOS-substrate L-arginine, given alone and/or in combination, were administered after lidocaine application in rats or in an in vitro HEK293 cell model, showing the presence of endogenous voltage-gated potassium (K + ), sodium (Na + ), and calcium (Ca 2+ ) channels [42].…”

Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye's Stress Coping Response: Progress, Achievements, and the Future

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Illustratively, beneficial activity in heart assay includes counteraction of the doxorubicin cardiomyopathy, 41 distinctive arrhythmias induced by digitalis, 42 hyperkalemia, 43 hypokalemia, 44 succinylcholine, 45 bupivacaine, 46 and neuroleptics. 47 Pleotropic beneficial activity based on the opposing relationship with alcohol and NSAIDs adverse effects In general cytoprotective/adaptive cytoprotection/organoprotection terms, and pleotropic range of the beneficial activities of BPC 157, and its opposing relationship with the alcohol and NSAIDs adverse effects, already reviewed, 8,11 this extension is quite logical. The major argument is that the Robert's standard noxious agents, alcohol and NSAIDs, used as the prototype noxious agents in the initial demonstration of the cytoprotection lesions in the stomach, have pleotropic damaging activity.…”

“…2 Of note, BPC 157 recovery muscle and muscle function occurs upon direct traumas (that would result in the severe injuries that would be hardly healed spontaneously). [69][70][71][72][73] Likewise, it occurs after vascular occlusion, 94 neuromuscular blockade (succinylcholine application), 45 potassium or magnesium overload, 43,111 dopamine system failure (nigrostriatal damage [1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP]), 130 vesicle depletion (reserpine), 132 dopamine receptors blockade (haloperidol and other dopamine antagonists), 47,116,135 or dopamine receptors supersensitivity (amphetamine after haloperidol) 133 or dopamine over-release (amphetamine). 133,134 In addition, BPC 157 recovers also smooth muscle functions, that is, sphincters [144][145][146][147] (lower esophageal, pyloric, [144][145][146] urinary, 147 pupil 112 ), upon direct injury (stretching), [144][145][146][147] indirect injury (fistula, [82][83][84] anastomosis, 87 ) or damaging agents (alcohol, 52 potassium or magnesium overload, 43,111 NSAIDs, 115 neuroleptics, 116 NO-agents, 112,116 atropine 112 ) application.…”