BPH and prostate cancer risk

Abstract

Introduction:With the exclusion of non-melanomatous skin malignancy, prostate cancer (PCa) is the second most prevalent cancer in men globally. It has been reported that the majority of men will develop benign prostatic hyperplasia (BPH) by the time they reach their 60s. Together, these prostatic diseases have a significant morbidity and mortality affecting over a billion men throughout the world. The risk of developing prostate cancer of men suffering BPH is one that has resulted in a healthy debate amongst the urological community. Here, we try to address this conundrum with clinical and basic science evidence.Materials and Methods:Data from an online search and contemporary data presented at international urological congresses was reviewed.Results:BPH and PCa can be linked together at a molecular and cellular level on genetic, hormonal, and inflammatory platforms suggesting that these prostatic diseases have common pathophysiological driving factors. Epidemiological studies are weighted towards the presence of BPH having a greater risk for a man to develop PCa in his lifetime; however, a conclusion of causality cannot be confidently stated.Conclusion:The future workload healthcare practitioners will face regarding BPH, and PCa will substantially increase. Further basic science and large epidemiological studies using a global cohort of men are required prior to the urological community confidently counseling their patients with BPH with regards to their PCa risk.

Pattern of Prostate Specific Antigen and Gleason Score in Relation to Imunohistochemistry Features in Prostate Adenocarcinoma Patients in Dr. Hasan Sadikin General Hospital

“…About 20% of the prostate adenocarcinoma is found incidentally in a histopatological procedure for examining the prostate gland based on the indication of hyperplasia. 3 Adenocarcinoma prostate showed a high morbidity and mortality with a number of 234.460 diagnosed and 27.350 passed away after diagnosed. 4 A study found more than 230.000 new cases and 30.000 of them was death.…”

TRANSCRIPTION FACTOR BRN-3α AND PROSTATE CANCER, RELATION WITH HORMONE RECEPTORS AND AKT/M-TOR SIGNALING PATHWAY ACTIVATION

“…К его значи-мым компонентам относят протеинкиназы AKT, m-TOR, PTEN и др. Известно, что мужчины с доброкачественной гиперплазией предстательной железы (ДГПЖ) имеют больший риск развития РПЖ [10]. В настоящее время превалирует точка зрения об общности патогенетических процессов, лежащих в основе развития ДГПЖ и РПЖ [11].…”

Assessment of the Potential Risk Factors of Prostate Cancer: A Comparative Study

“…There were some studies that confirm validity of this study. Carter et al [11], showed that 50% of men between 70 and 80 years of age showed histological evidence of malignancy. At that time risk of 42% for developing histological evidence of prostate cancer in 50-year-old men had been calculated.…”