Twistors in four dimensions d = 4 have provided a convenient description of massless particles with any spin, and this led to remarkable computational techniques in Yang-Mills field theory. Recently it was shown that the same d = 4 twistor provides also a unified description of an assortment of other particle dynamical systems, including special examples of massless or massive particles, relativistic or non-relativistic, interacting or non-interacting, in flat space or curved spaces. In this paper, using 2T-physics as the primary theory, we derive the general twistor transform in d-dimensions that applies to all cases, and show that these more general twistor transforms provide d dimensional holographic images of an underlying phase space in flat spacetime in d + 2 dimensions. Certain parameters, such as mass, parameters of spacetime metric, and some coupling constants appear as moduli in the holographic image while projecting from d + 2 dimensions to (d − 1) + 1 dimensions or to twistors. We also extend the concept of twistors to include the phase space of D-branes, and give the corresponding twistor transform. The unifying role for the same twistor that describes an assortment of dynamical systems persists in general, including D-branes. Except for a few special cases in low dimensions that exist in the literature, our twistors are new.