Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study

Wang, Anxin; Su, Zhaoping; Liu, Xiaoxue; Yang, Yi; Chen, Shuohua; Wang, Shuzhen; Luo, Yanxia; Guo, Xiuhua; Wang, Wenjuan; Wu, Shouling

doi:10.1186/s12872-016-0409-x

Cited by 19 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning the impact of other CV risk factors on PWV, literature is currently inconsistent. Besides age and blood pressure, BMI, central obesity, triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting plasma glucose (FPG) and uric acid (UA) were reported to be associated with baPWV [ 23 , 26 – 28 , 31 ]. We could confirm these significant associations in our cohort.…”

Section: Discussionmentioning

confidence: 99%

“…While previous studies demonstrated that age and hypertension [ 14 , 23 , 24 ] strongly influence PWV, the impact of other conventional atherosclerotic risk factors, such as diabetes mellitus [ 25 ], metabolic syndrome [ 26 – 28 ], and smoking [ 29 , 30 ] is inconsistent. Reference values based on a large-scale European population have only been established for the gold standard cfPWV by one multi-centre study [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Baier

Teren

Wirkner³

et al. 2018

Clin Res Cardiol

View full text Add to dashboard Cite

Aims and backgroundParameters of arterial stiffness such as pulse wave velocity (PWV) were recently proposed as independent risk factors of cardiovascular events. We analyse three PWV parameters in the large population-based study LIFE-Adult to identify risk factors, normal and reference values.Methods and resultsBrachial-ankle (ba), brachial-femoral (bf) and carotid-femoral (cf) PWV assessment was performed using Vicorder device. 8509 participants aged 19–80 were analysed. PWV parameters were moderately correlated (r(ba/bf) = 0.6, r(ba/cf) = 0.46, r(bf/cf) = 0.59). Age and blood pressure are the dominant determinants of PWV parameters explaining > 18% of variability. Sex was only relevant for bfPWV and cfPWV. All further analysed cardiovascular and other risk factors are of minor importance. We provide age-dependent percentiles for the population (reference values) and for the subgroup of normotonic individuals. All percentiles show a strong increase with age. The difference between normotonic and all individuals is small for younger age groups but increases up to 1 m/s for elderly subjects.ConclusionOur study confirms and further underpins the strong impact of age and blood pressure on arterial stiffness and the relatively weak contribution of other factors, supporting an independent role of arterial stiffness in cardiovascular disease development. Age-dependent reference and normal values were provided on the basis of the so far largest study sample facilitating the implementation of PWV assessment in clinical practice. Due to better compliance, handling and stronger association with age and blood pressure, baPWV could serve as an alternative to cfPWV. Follow-up data are required to estimate the clinical significance of specified PWV cut-offs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Baier

Teren

Wirkner³

et al. 2018

Clin Res Cardiol

View full text Add to dashboard Cite

show abstract

“…Individuals with MetS have twofold risk of presenting stiff arteries when compared to individuals without MetS, even after controlling for age, sex and occurrence of diabetes mellitus [ 14 ]. Arterial stiffness of central arterial segments is normally identified before clinical manifestations of cardiovascular disease [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness and its association with clustering of metabolic syndrome risk factors

Lopes-Vicente

Rodrigues

Cepeda

et al. 2017

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundMetabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients.MethodsRecently diagnosed and untreated patients with MetS (n = 64, 49 ± 8 year, 32 ± 4 kg/m2) were selected, according to ATP III criteria and compared to a control group (Control, n = 17, 49 ± 6 year, 27 ± 2 kg/m2). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations.ResultsPatients with MetS had increased PWV when compared to Control (7.8 ± 1.1 vs. 7.0 ± 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (β = 0.450, p < 0.001), systolic blood pressure (β = 0.211, p = 0.023) and triglycerides (β = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 ± 0.4 vs. 7.5 ± 0.2, p = 0.011 and 7.2 ± 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 ± 0.2 vs. 7.2 ± 0.3, p = 0.047).ConclusionsThe number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients.

show abstract

“…Pulse wave velocity (PWV) is a method of measuring arterial stiffness that indirectly presents as a surrogate marker for CVD risk and is closely correlated with the parameters of metabolic syndrome [ 22 , 23 ]. Carotid-femoral PWV (cfPWV) is considered the gold-standard measurement for arterial stiffness [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women

Han

Chun

Kim

et al. 2017

International Journal of Endocrinology

View full text Add to dashboard Cite

The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who participated in the health checkup programs in one hospital. The brachial-ankle pulse wave velocity (baPWV) was measured as a marker for arterial stiffness. A negative correlation was observed between SHBG levels and baPWV (rho = −0.281). The relationship was significant even after adjusting for potential confounders (beta = −0.087 in fully adjusted model). After considering the interaction between central obesity and SHBG levels, the significant association was evident only in obese women (P for interaction = 0.025). Adjustment for a 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores, instead of each cardiovascular risk factor individually, did not affect the significance of the relationship between SHBG levels and baPWV. Serum levels of SHBG were negatively associated with arterial stiffness independent of cardiovascular risk factors or 10-year ASCVD risk scores in Korean women. The relationship may be potentiated by central obesity.

show abstract

Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study

Cited by 19 publications

References 30 publications

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult

Arterial stiffness and its association with clustering of metabolic syndrome risk factors

Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women

Contact Info

Product

Resources

About