Brachial-ankle pulse wave velocity is associated with composite carotid and coronary atherosclerosis in a middle-aged asymptomatic population

Joo, Hyung Joon; Cho, S.A.; Cho, J.Y.; Lee, Sunwoong; Park, J.H.; Hwang, Sung Ho; Hong, Soon Jun; Yu, Cheol Woong; Lim, Do–Sun

doi:10.1016/j.atherosclerosis.2016.07.248

Cited by 2 publications

(4 citation statements)

References 29 publications

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“…When considering the amplitude of this association, an average increase in baPWV of 1 m/s corresponds to a 5% increased risk of carotid plaque presence. These findings are consistent with Joo et al [24]. However, Joo et al found that a 1 m/s increase in baPWV corresponded to a 38% increase in carotid plaque presence, which is much higher than the data in our study (5%).…”

Section: Discussionsupporting

confidence: 93%

“…Munakata et al [23] reported that higher baPWV was associated with greater max CIMT or carotid plaque score in patients with end-stage renal disease. Joo et al [24] revealed that in a middle-aged asymptomatic population, subjects with higher baPWV had a higher prevalence of carotid plaque. Yang et al [25] demonstrated that baseline baPWV is independently associated with the risk of new carotid plaque formation in a community population.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with carotid-femoral PWV (cfPWV), brachial-ankle PWV (baPWV) is an even simpler noninvasive and automatic measurement and provides a more convenient technique to evaluate artery stiffness, especially in large clinical trials. Previous studies have suggested that baPWV is significantly associated with the existence of atherosclerosis in the general male population, in endstage renal disease subjects, in the middle-aged asymptomatic population and in the community-based population [22][23][24][25]. However, to our knowledge, no study has evaluated this association, specifically in the hypertensive population.…”

Section: Introductionmentioning

confidence: 89%

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Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

et al. 2020

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We aimed to investigate the association of brachial-ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04-1.07) and carotid plaque number (one-to two-plaque group: OR = 1.04, 95% CI: 1.02-1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07-1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dosedependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants. Keywords Brachial-ankle pulse wave velocity • Carotid plaque presence • Carotid plaque number • Hypertension • Age

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

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Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

et al. 2020

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“…A higher brachial-ankle PWV was significantly associated with a higher risk of CVD, as tyrosine kinase, phosphatidyl inositol-3-kinase, protein kinase C, epithelial sodium channel, and/or nicotinamide adenine dinucleotide phosphate oxidase signalings, and activations of these signaling cascades are thought to contribute to the initiation/progression of atherosclerosis and also to arterial wall thickening 79,80) . In addition, local arterial stiffness may affect the arterial vulnerability to plaque formation 81) , and an association has been reported between arterial stiffness and carotid atherosclerosis 68,82) . Recently, we reported from the FMD-J multicenter prospective observational study conducted in subjects with hypertension (FMD-J study B), that increased arterial stiffness rather than endothelial dysfunction may be more closely associated with the progression of carotid atherosclerosis 83) .…”

Section: -2-1: Heartmentioning

confidence: 99%

State of the Art Review: Brachial-Ankle PWV

Tomiyama

Shiina

2020

JAT

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The brachial-ankle pulse wave velocity (brachial-ankle PWV), which is measured simply by wrapping pressure cuffs around the four extremities, is a simple marker to assess the stiffness of the medium- to large- sized arteries. The accuracy and reproducibility of its measurement have been confirmed to be acceptable. Risk factors for cardiovascular disease, especially advanced age and high blood pressure, are reported to be associated with an increase of the arterial stiffness. Furthermore, arterial stiffness might be involved in a vicious cycle with the development/progression of hypertension, diabetes mellitus and chronic kidney disease. Increase in the arterial stiffness is thought to contribute to the development of cardiovascular disease via pathophysiological abnormalities induced in the heart, brain, kidney, and also the arteries themselves. A recent independent participant data meta-analysis conducted in Japan demonstrated that the brachial-ankle PWV is a useful marker to predict future cardiovascular events in Japanese subjects without a previous history of cardiovascular disease, independent of the conventional model for the risk assessment. The cutoff point may be 16.0 m/s in individuals with a low risk of cardiovascular disease (CVD), and 18.0 m/s in individuals with a high risk of CVD and subjects with hypertension. In addition, the method of measurement of the brachial-ankle PWV can also be used to calculate the inter-arm systolic blood pressure difference and ankle-brachial pressure index, which are also useful markers for cardiovascular risk assessment.

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Brachial-ankle pulse wave velocity is associated with composite carotid and coronary atherosclerosis in a middle-aged asymptomatic population

Cited by 2 publications

References 29 publications

Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

Association of brachial–ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age

State of the Art Review: Brachial-Ankle PWV

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