Brachial-Ankle Pulse Wave Velocity Predicts Silent Cerebrovascular Diseases in Patients with End-Stage Renal Diseases

Abstract

Aim: Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD. Methods: CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with brain magnetic resonance imaging (MRI), and carotid/intracranial artery magnetic resonance angiography (MRA) in 44 pre-dialytic patients. The severity of CVD was evaluated by the number of lacunes and the degree of stenosis, respectively. The association between CVD and atherosclerotic parameters was evaluated. Results: Patients with severe lacunes (n 18) manifested older age, lower diastolic blood pressure, serum creatinine and albumin, and higher CRP and serum calcium than those with absent-moderate lacunes (n 26). When assessed by multivariate analysis, only baPWV was adopted as an independent risk factor for severe lacunes. Furthermore, baPWV and i-PTH were associated with the severity of carotid/intracranial artery stenosis, both of which were independent of other risk factors, including age and diabetes. Conclusions: Arterial stiffness may constitute a novel determinant predicting the severity of CVD in pre-dialytic patients besides classical risk factors. J Atheroscler Thromb, 2010; 17:165-172.

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study

“…To our knowledge, this is the first cohort study to show the impact of ADIPOQ G276T on prognoses and to suggest a mechanism of how ADIPOQ G276T affects the onset of stroke. Previous studies reported the correlation between PWV and silent cerebrovascular diseases 38) or insulin resistance 39) , and our results supported and provided new insight into these correlations.…”

Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients

“…PWV is a predictor of cardiovascular outcome in HD patients 23,24) . Washida et al have recently reported that arterial stiffness constitutes a novel determinant that predicts the severity of CVD in patients with ESRD in addition to the classical risk factors, and they have shown lower serum albumin levels and higher serum CRP levels in HD patients with severe lacunes 25) . Evidence has shown that atherosclerosis reflects the vascular inflammatory process 26) .…”

Relationship between Arterial Stiffness Assessed by Brachial-Ankle Pulse Wave Velocity and Coronary Artery Disease Severity Assessed by the SYNTAX Score

“…A lesion was defined as significant if it caused 50% reduction of the luminal diameter by visual estimation in vessels ≥ 1.5 mm. Each coronary lesion was separately scored and added to each coronary vessel to provide the vessel SYNTAX scores, which were then summed to provide the overall patient SYNTAX score, as previously described 13,14) , chial-ankle PWV (baPWV) has become available as a means of measuring PWV [7][8][9][10] . BaPWV can be obtained simply by wrapping the four extremities with blood pressure cuffs, and it has been suggested that this automatic, non-invasive device has the potential to be a simple marker of vascular damage severity 7) .…”