Brachial-Ankle Pulse Wave Velocity Predicts Increase in Blood Pressure and Onset of Hypertension

Takase, Hiroyuki; Dohi, Yasuaki; Toriyama, Takayuki; Okado, T; Tanaka, Satoru; Sonoda, Hiroo; Sato, Koichi; Kimura, Genjiro

doi:10.1038/ajh.2011.19

Cited by 101 publications

(76 citation statements)

References 24 publications

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“…5 Several studies have established an important relationship between PWV (either carotid-femoral PWV [cfPWV] or brachial-ankle PWV [baPWV]) and BP progression. [6][7][8] Our previous study showed that baPWV was an independent determinant of individual response to antihypertensive treatment. 9 Particularly relevant to this report, recent longitudinal studies have demonstrated that increased baPWV levels predict cardiovascular mortality and morbidity among high-risk patients and the general population.…”

Section: Song Et Al Bapwv and Bp Control Predict First Incident Strokmentioning

confidence: 98%

Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults

Song

et al. 2016

Hypertension

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Stroke Association's updated guidelines on the primary prevention of stroke, treatment of hypertension is among the most effective strategies for preventing both ischemic and hemorrhagic stroke. 4 Little is known, however, about the role of pulse wave velocity (PWV), a marker of arterial stiffness, in the primary prevention of stroke. There is a growing recognition that PWV may affect blood pressure (BP) and the response to antihypertension treatment. Large arterial stiffness and wave-reflection intensity have both been associated with Abstract-Pulse wave velocity (PWV) has been shown to influence the effects of antihypertensive drugs in the prevention of cardiovascular diseases. Data are limited on whether PWV is an independent predictor of stroke above and beyond hypertension control. This longitudinal analysis examined the independent and joint effect of brachial-ankle PWV (baPWV) with hypertension control on the risk of first stroke. This report included 3310 hypertensive adults, a subset of the China Stroke Primary Prevention Trial (CSPPT) with baseline measurements for baPWV. During a median follow-up of 4.5 years, 111 participants developed first stroke. The risk of stroke was higher among participants with baPWV in the highest quartile than among those in the lower quartiles (6.3% versus 2.4%; hazard ratio, 1.66; 95% confidence interval, 1.06-2.60). Similarly, the participants with inadequate hypertension control had a higher risk of stroke than those with adequate control (5.1% versus 1.8%; hazard ratio, 2.32; 95% confidence interval, 1.49-3.61). When baPWV and hypertension control were examined jointly, participants in the highest baPWV quartile and with inadequate hypertension control had the highest risk of stroke compared with their counterparts (7.5% versus 1.3%; hazard ratio, 3.57; 95% confidence interval, 1.88-6.77). There was a significant and independent effect of high baPWV on stroke as shown among participants with adequate hypertension control (4.2% versus 1.3%; hazard ratio, 2.29, 95% confidence interval, 1.09-4.81). In summary, among hypertensive patients, baPWV and hypertension control were found to independently and jointly affect the risk of first stroke. Participants with high baPWV and inadequate hypertension control had the highest risk of stroke compared with other groups.

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Section: Song Et Al Bapwv and Bp Control Predict First Incident Strokmentioning

confidence: 98%

Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults

Song

et al. 2016

Hypertension

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“…Further studies are needed to evaluate the applicability of brachialankle PWV as a marker to assess the effect of treatment on the prognosis. In addition to predicting future cardiovascular events 63, , brachial-ankle PWV can also predict the development of hypertension or stage III chronic kidney disease 63,64,116,117) . Therefore, measurement of the brachial-ankle PWV may also be useful to identify the pathophysiological abnormalities related to atherosclerotic cardiovascular disease in the early stages 6) .…”

Section: Effects Of Treatmentmentioning

confidence: 99%

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

Tomiyama

Matsumoto

Shiina

et al. 2016

J Atheroscler Thromb

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Since 2001, brachial-ankle pulse wave velocity (brachial-ankle PWV) measurement has been applied for risk stratification of patients with atherosclerotic cardiovascular disease and/or its risk factors in Japan. Measurement of the brachial-ankle PWV is simple and well standardized, and its reproducibility and accuracy are acceptable. Several cross-sectional studies have demonstrated a significant correlation between the brachial-ankle PWV and known risk factors for cardiovascular disease; the correlation is stronger in subjects with cardiovascular disease than in those without cardiovascular disease. We conducted a meta-analysis, which demonstrated that the brachial-ankle PWV is an independent predictor of future cardiovascular events. Furthermore, the treatment of cardiovascular risk factors and lifestyle modifications have been shown to improve the brachial-ankle PWV. Thus, at present, brachial-ankle PWV is close to being considered as a useful marker in the management of atherosclerotic cardiovascular disease and/or its risk factors.

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“…[2][3][4] A recent study showed that baPWV was an independent determinant of an individual response to antihypertensive treatment. 5) In addition, recent longitudinal studies have demonstrated that increased baPWV levels predict cardiovascular mortality and morbidity among high-risk patients and the general population.…”

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confidence: 99%

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

Liu

Sun

Yu³

et al. 2016

Int. Heart J.

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SummaryThis study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults.The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14.9 μmol/L; ≥ 15.0 μmol/L) and FBG: normal (FBG < 5.6 mmol/L), impaired (5.6 mmol/L ≤ FBG < 7.0 mmol/L), and diabetes mellitus (FBG ≥ 7.0 mmol/L). We performed linear regression analyses to evaluate their associations with baPWV with adjustment for covariables.When analyzed individually, BP, Hcy, and FBG were each associated with baPWV. When BP and FBG were analyzed jointly, the highest baPWV value (mean ± SD: 2227 ± 466 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and SBP ≥ 180 mmHg (β = 432.5, P < 0.001), and the lowest baPWV value (mean ± SD: 1692 ± 289 cm/s) was seen in participants with NFG and SBP < 160 mmHg. When Hcy and FBG were analyzed jointly, the highest baPWV value (2072 ± 480 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and Hcy ≥ 15.0 μmol/L (β = 167.6, P < 0.001), while the lowest baPWV value (mean ± SD: 1773 ± 334 cm/s) was observed in participants with NFG and Hcy < 10 μmol/L.In Chinese hypertensive adults, SBP, Hcy, and FBG are individually and jointly associated with baPWV. Our findings underscore the importance of identifying individuals with multiple risk factors of baPWV including high SBP, FBG, and Hcy. (Int Heart J 2016; 57: 627-633) Key words: Hypertension, Arterial stiffness, Diabetes, MTHFR T here is a growing recognition of the potential important role of pulse wave velocity (PWV), a marker of arterial stiffness, in relation to cardiovascular risk, including isolated systolic hypertension (ISH) 1) and blood pressure (BP) progression.2-4) A recent study showed that baPWV was an independent determinant of an individual response to antihypertensive treatment.5) In addition, recent longitudinal studies have demonstrated that increased baPWV levels predict cardiovascular mortality and morbidity among high-risk patients and the general population. [6][7][8][9] Like blood pressure, arterial stiffness can be easily and noninvasively assessed by measuring the pulse wave velocity (PWV).10) The measurement of brachial-ankle PWV (baPWV) is an index of central arterial stiffness with a good correlation with the aortic PWV, 11,12) and is suitable for screening large populations in clinical and community settings.From the

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Brachial-Ankle Pulse Wave Velocity Predicts Increase in Blood Pressure and Onset of Hypertension

Abstract: This study provides the first evidence that baPWV is an independent predictor of longitudinal increases in BP as well as of new onset of hypertension.

Cited by 101 publications

References 24 publications

Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults

Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults

Brachial-Ankle PWV: Current Status and Future Directions as a Useful Marker in the Management of Cardiovascular Disease and/or Cardiovascular Risk Factors

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

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