Brachial artery blood flow measurement: A simple and noninvasive method to evaluate the need for arteriovenous fistula repair

Ogawa, Tomonari; Matsumura, Osamu; Matsuda, Akihiko; Hasegawa, Hajime; Mitarai, Tetsuya

doi:10.1002/dat.20565

Cited by 19 publications

(9 citation statements)

References 19 publications

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“…Finally, in principle DiFC could be used in larger species and potentially even humans, since it uses highly scattered light in an epi-illumination and detection optical configuration. Theoretically, there are many superficial blood vessels that could be probed with DiFC, for example the cephalic vein in the forearm 30 . However, fluorescent labeling of target cell populations would require the use of molecularly-targeted fluorescent probes, such as those in clinical trials for fluorescence guided surgery 31 .…”

Section: Discussionmentioning

confidence: 99%

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

Tan

Patil

Bartosik

et al. 2019

Sci Rep

100

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Circulating tumor cells (CTCs) are of great interest in cancer research, but methods for their enumeration remain far from optimal. We developed a new small animal research tool called “Diffuse in vivo Flow Cytometry” (DiFC) for detecting extremely rare fluorescently-labeled circulating cells directly in the bloodstream. The technique exploits near-infrared diffuse photons to detect and count cells flowing in large superficial arteries and veins without drawing blood samples. DiFC uses custom-designed, dual fiber optic probes that are placed in contact with the skin surface approximately above a major vascular bundle. In combination with a novel signal processing algorithm, DiFC allows counting of individual cells moving in arterial or venous directions, as well as measurement of their speed and depth. We show that DiFC allows sampling of the entire circulating blood volume of a mouse in under 10 minutes, while maintaining a false alarm rate of 0.014 per minute. In practice, this means that DiFC allows reliable detection of circulating cells below 1 cell per mL. Hence, the unique capabilities of DiFC are highly suited to biological applications involving very rare cell types such as the study of hematogenous cancer metastasis.

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Section: Discussionmentioning

confidence: 99%

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

Tan

Patil

Bartosik

et al. 2019

Sci Rep

100

View full text Add to dashboard Cite

show abstract

“…Theoretically, there are many superficial blood vessels that could be probed with DiFC, for example the cephalic vein in the forearm 26…”

Section: Discussionmentioning

confidence: 99%

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

Tan

Patil

Bartosik

et al. 2018

Preprint

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Circulating tumor cells (CTCs) are of great interest in cancer research, but methods for their enumeration remain far from optimal. We developed a new small animal research tool called "Diffuse in vivo Flow Cytometry" (DiFC) for detecting extremely rare fluorescentlylabeled circulating cells directly in the bloodstream. The technique exploits near-infrared diffuse photons to detect and count cells flowing in large superficial arteries and veins without drawing blood samples. DiFC uses custom-designed, dual fiber optic probes that are placed in contact with the skin surface approximately above a major vascular bundle. In combination with a novel signal processing, algorithm DiFC allows counting of individual cells moving in arterial or venous directions, as well as measurement of their speed and depth. We show that DiFC allows sampling of the entire circulating blood volume of a mouse in under 10 minutes, while maintaining a false alarm rate of 0.014 per minute. Hence, the unique capabilities of DiFC are highly suited to biological applications involving very rare cell types such as the study of hematogenic cancer metastasis.

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“…The mean FV was measured in both brachial arteries via Doppler ultrasound (Aplio 500, TUS-A500; Toshiba Medical Systems Co., Otawara, Japan). FV was defined as the difference between flow in the arm with the shunt and the contralateral arm, 4 and FVs were compared before and after blood flow suppression.…”

Section: Methodsmentioning

confidence: 99%

Features of high flow access in the elderly

Kanno¹,

Kanno²,

Shiroi³

et al. 2019

J Vasc Access

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Introduction: The number of elderly hemodialysis patients continues to grow. The aim of this study was to investigate differences in elderly high flow access patients compared with middle-aged and young patients. Methods: We performed a retrospective study to determine the characteristics of elderly patients (aged >60 years) following blood flow suppression procedures. Preoperative and postoperative data from 177 patients who underwent blood flow suppression procedures and 73 patients who underwent procedures for runoff vein ligation and subcutaneous fixation of the superficial artery were compared. Results: A high proportion of young (aged 20-40 years) and middle-aged (aged 41-60 years) patients met the criteria for blood flow suppression procedures (flow volume 1500 mL/min, flow volume/cardiac output 35%), whereas a high proportion of elderly patients did not. Moreover, heart strain could evidently be caused even with low flow volume. In elderly patients, a tricuspid regurgitation pressure gradient and right heart strain were observed more frequently. Conclusion: Elderly patients who underwent blood flow suppression procedures or subcutaneous fixation of the superficial artery exhibited lower flow volume, and the effects of high flow access in elderly patients depend on the nature of vascular changes. Ultimately, the underlying conditions and hemodynamics of each patient must be determined on an individual basis.

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Brachial artery blood flow measurement: A simple and noninvasive method to evaluate the need for arteriovenous fistula repair

Cited by 19 publications

References 19 publications

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

In Vivo Flow Cytometry of Extremely Rare Circulating Cells

Features of high flow access in the elderly

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