Brachial artery dilatation responses in healthy children and adolescents

Järvisalo, Mikko J.; Rönnemaa, Tapani; Volanen, Iina; Kaitosaari, Tuuli; Kallio, Katariina; Hartiala, Jaakko; Irjala, Kerttu; Viikari, Jorma; Simell, Olli; Raitakari, Olli T.

doi:10.1152/ajpheart.2002.282.1.h87

Cited by 88 publications

(93 citation statements)

References 23 publications

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“…This finding agrees with other studies that reported a relationship between serum cholesterol, endothelial dysfunction, and intimal-medial thickness (13,14).…”

Section: Discussionsupporting

confidence: 93%

Lesiones ateroscleróticas tempranas y nivel de colesterol post mortem en un grupo de niños colombianos

Ortega¹,

Mosquera²,

Echeverri³

et al. 2013

biomedica

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Introduction: Atherosclerosis is an asymptomatic chronic disease, which begins at early age and is difficult to detect during this stage. Prospective studies suggest a causal relationship between total serum cholesterol levels during childhood and early adolescence and the development of cardiovascular diseases in adulthood.Objective: The aim of this study was to evaluate the prevalence of early atherosclerotic lesions in the aorta artery of children and its relationship with post-mortem serum cholesterol levels. Material and methods: Post-mortem samples of blood and aorta were taken from 43 subjects aged less than 17 years old. Histopathological analysis (intimal thickening and inflammatory infiltrates) of the thoracic aorta and measurement of total serum cholesterol were performed. Results:The analysis showed thickening of the intima and lymphocyte infiltrates in 93% of children, and macrophage infiltrates in 79.1% of cases. A relationship between the highest terciles of total serum cholesterol levels and the presence of multiple lesions in the aorta wall was found (P<0.05).Conclusion: This group of children had a high prevalence of early inflammatory atherosclerotic lesions positively related with serum cholesterol levels. To our knowledge this study represents the first report of a relationship between post-mortem total serum cholesterol levels and pathological findings of macrophages and lymphocytes infiltrates in the aorta wall.

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“…This finding agrees with other studies that reported a relationship between serum cholesterol, endothelial dysfunction, and intimal-medial thickness (13,14).…”

Section: Discussionsupporting

confidence: 93%

Lesiones ateroscleróticas tempranas y nivel de colesterol post mortem en un grupo de niños colombianos

Ortega¹,

Mosquera²,

Echeverri³

et al. 2013

biomedica

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“…In addition, the timing of the measurement after cuff deflation may explain our negative result. Järvisalo et al (22) has found a great variation in the FMD as a function of the time after cuff deflation in healthy children. We chose to delay the measurement until 80-90 s after deflation to identify the late responders also, but the relatively large SD of the FMD may result from the variance in the response time in our patients.…”

Section: Discussionmentioning

confidence: 97%

“…We chose to delay the measurement until 80-90 s after deflation to identify the late responders also, but the relatively large SD of the FMD may result from the variance in the response time in our patients. Continuous registration of the vessel diameter from 30 to 150 s is recommended to overcome the problem of the individual variation in FMD (22).…”

Section: Discussionmentioning

confidence: 99%

Time-related arterial changes after allogeneic hematopoietic stem cell transplantation in children

et al. 2013

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Background: Metabolic syndrome is a frequent late effect in young adults after hematopoietic stem cell transplantation (HSCT) performed in childhood. Methods: To further study the signs of cardiovascular changes in HSCT patients, we performed noninvasive vascular ultrasonic measurements of arterial stiffness and endothelial function in 25 children (median age: 11.2 y) and in 22 healthy matched controls. results: The distensibility of the common carotid artery (CCA) was significantly lower in the patients than in the controls (mean = 0.48, SD = 0.19 vs. mean = 0.64 mm Hg −1 × 10 −2 , SD = 0.28; P = 0.024). The distensibility decreased with time passed after HSCT (P = 0.009). The compliance of the CCA was decreased (mean = 0.10, SD = 0.04 vs. mean = 0.13 mm 2 × mm Hg −1 , SD = 0.05; P = 0.041), and the incremental elastic modulus (E inc) was higher in the patients than in the controls (mean = 2.05, SD = 0.7 vs. mean = 1.6 mm × 10 3 , SD = 0.6; P = 0.019). E inc was associated with time passed after HSCT (P = 0.036). The size of the brachial artery and flow-mediated dilation did not differ between the groups. conclusion: Early mechanical changes of the arterial wall were found at young age after HSCT. Ultrasonography may offer a noninvasive method to find early alterations of the vascular bed and to optimize prevention of atherosclerosis in HSCT patients.

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“…14,15 There are no other studies on medical literature indexes that define standards for normal endothelial function in adolescents.…”

Section: Methodsmentioning

confidence: 99%

Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial

Andrade¹,

Carvalhaes²,

Taddei³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To define standards for normal endothelial function in adolescents by high-resolution ultrasound measurement of endothelium-dependent vascular dilatation.Methods: This was a cross-sectional, descriptive, observational study and part of the thematic project Clinical Study of Growth, Behavior, Arterial Hypertension, Obesity and Oral Health (ECCCHOS) that was developed by the Discipline of Nutrition at the Universidade Federal de São Paulo. Thirty-one adolescents, eight male and 23 female, with no risk factors for systemic arterial hypertension were selected from 1,420 high-school students. The students were daytime pupils at a school in the southeastern district of the city of São Paulo, the capital of São Paulo state, located in the Southeast region of Brazil. All results are presented in the form of means with standard deviations and percentiles.Results: For male students, endothelium-dependant dilation 90 seconds after the cuff was released was 20.9±6,7% [mean ±1 standard deviation] with a 10th percentile of 12.5 and for females these figures were 18.8±12.9% with a 10th percentile of 6.6%. Values for the whole group of subjects were 19.3±11.7% and 6.7%, respectively.Conclusion: Endothelium-dependant vascular dilation of 6.7%, after 90 seconds, which corresponds to the 10th percentile, can be considered the lower limit of normality for this age group. Knowledge of this limit is important for the diagnosis of endothelium dysfunction that appears before cardiovascular disease.J Pediatr (Rio J). 2005;81(5):395-9: Adolescents, endothelium, and ultrasound.

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Brachial artery dilatation responses in healthy children and adolescents

Cited by 88 publications

References 23 publications

Lesiones ateroscleróticas tempranas y nivel de colesterol post mortem en un grupo de niños colombianos

Lesiones ateroscleróticas tempranas y nivel de colesterol post mortem en un grupo de niños colombianos

Time-related arterial changes after allogeneic hematopoietic stem cell transplantation in children

Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial

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