Brachial artery low-flow-mediated constriction is increased early after coronary intervention and reduces during recovery after acute coronary syndrome: characterization of a recently described index of vascular function

Spiro, Jonathan; Digby, Janet E.; Ghimire, Gopal; Mason, Mark; Mitchell, Andrew; Ilsley, Charles; Donald, Ann; Dalby, Miles; Kharbanda, Rajesh K.

doi:10.1093/eurheartj/ehq401

Cited by 48 publications

(57 citation statements)

References 29 publications

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“…There is some evidence that impaired vascular function in the radial artery is associated with diminished L-FMC responses, 1,3 whereas brachial artery L-FMC may be increased in subjects with risk factors or coronary disease. 5,21,22 Our findings are in broad agreement with previous studies of the radial artery, 1,3 but contrast with those in the brachial artery, reinforcing a previous suggestion of arterial site specificity in vasoconstrictor function. 4 Furthermore, the impact of coronary catheterization on systemic conduit artery This study had a number of limitations.…”

Section: Discussionsupporting

confidence: 91%

“…[1][2][3][4][5] Previous studies have demonstrated that clinical groups that exhibit impaired flow-mediated dilatation (FMD) also present with a reduced radial artery vasoconstrictor L-FMC, although the 2 are not correlated in patients with cardiovascular disease. 1,2 While FMD has been demonstrated to be endothelium-and shear stress-dependent, less is known about the mechanisms responsible for L-FMC.…”

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confidence: 99%

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Low-Flow Mediated Constriction is Endothelium-Dependent

Dawson

Alkarmi

Thijssen

et al. 2012

Circ: Cardiovascular Interventions

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The aim of this study was therefore 2-fold: to examine the impact of catheterization on radial artery vasoconstrictor function (L-FMC) in the catheterized (Cath) and noncatheterized arms, and to examine the impact of localized handgrip exercise training on radial artery FMD and L-FMC after catheterization. We hypothesized that L-FMC would be Background-Radial artery catheterization is associated with endothelial denudation and impaired vasodilator function, while postcatheterization exercise training may enhance artery function. The impact of catheterization and subsequent exercise training on low-flow mediated vasoconstriction (L-FMC) has not previously been studied. The aim of this study was to examine whether radial artery L-FMC is impaired by catheterization and consequent endothelial denudation. A further aim was to examine the effect of local handgrip exercise training on radial artery L-FMC and flow-mediated dilation (FMD) after transradial catheterization. Methods and Results-Thirty-two subjects undergoing transradial catheterization underwent assessment of L-FMC and FMD in the catheterized and contralateral radial artery before, and the day after, catheterization. A further 18 patients were recruited and randomly assigned to either a 6-week handgrip exercise training program (N=9)

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Low-Flow Mediated Constriction is Endothelium-Dependent

Dawson

Alkarmi

Thijssen

et al. 2012

Circ: Cardiovascular Interventions

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“…Indeed, again a more sustained L-FMC occurred in subjects with unstable coronary artery disease compared with subjects with stable coronary artery disease. Spiro found no association between the baseline brachial artery diameter, peak FMD, and magnitude of constriction in subjects with coronary atherosclerosis 17) . L-FMC significantly and inversely correlated with peak FMD in healthy subjects.…”

Section: Resultsmentioning

confidence: 91%

“…However, the low-flowmediated vasoconstriction (L-FMC) seems to be specific to the radial artery because it has not been consistently described for the brachial artery. In addition, although the radial artery L-FMC seems to be a marker of normal endothelial function, it seems to have an opposite meaning when it occurs in the brachial artery 17) .…”

Section: Ultrasound Study Proceduresmentioning

confidence: 99%

Brachial Low-Flow-Mediated Constriction is Associated with Delayed Brachial Flow-Mediated Dilation

Irace

Tripolino

Scavelli

et al. 2016

JAT

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Aim: Flow-mediated vasodilation (FMD) of the brachial artery measures the ability of the artery to dilate after a forearm ischemia lasting for 5 min. During ischemia, and therefore in conditions of low flow, constriction of the brachial artery (L-FMC) has sometimes been reported. The meaning of L-FMC is still unclear. The aims of our study were to establish the prevalence of subjects with L-FMC, to determine whether the magnitude of L-FMC correlates with magnitude of FMD, and to determine whether L-FMC can be used to predict FMD timing. Methods: A total of 179 outpatients were studied, and the brachial artery diameter was measured every minute during the 5 min forearm ischemia. Subjects who had at least one measurement showing a constriction of 1% during ischemia were defined as constrictors. FMD was evaluated at 50 s, 2 min, and 3 min after cuff release. On the basis of time, the subjects in whom maximal dilation had occurred were divided into Early, Late, or No dilators. Conclusions:The present study reveals that almost 40% of the subjects had brachial artery L-FMC and a more pronounced constriction during ischemia correlated with a lower dilation after ischemia. Finally, the prevalence of subjects showing L-FMC was significantly higher among subjects with delayed or no vasodilation, suggesting that L-FMC may be a marker of endothelial dysfunction.

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“…The intraobserver CV calculated from baseline measurements (n = 39) was 19.6%. Low flow-mediated constriction (L-FMC) was calculated from the mean arterial diameter during the last 30 s before cuff release and expressed as the percentage of change from baseline (25).…”

Section: Fmd Analysismentioning

confidence: 99%

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

Blanch

Clifton

Petersen

et al. 2015

The American Journal of Clinical Nutrition

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Background: It is known that increased potassium and reduced sodium intakes can improve postprandial endothelial function. However, the effect of increasing potassium in the presence of high sodium in the postprandial state is not known. Objective: We aimed to determine the effect of high potassium and high sodium on postprandial endothelial function as assessed by using flow-mediated dilatation (FMD) and arterial compliance as assessed by using pulse wave velocity (PWV) and central augmentation index (AIx). Design: Thirty-nine healthy, normotensive volunteers [21 women and 18 men; mean 6 SD age: 37 6 15 y; BMI (in kg/m 2 ): 23.0 6 2.8] received a meal with 3 mmol K and 65 mmol Na (low-potassium, high-sodium meal (LKHN)], a meal with 38 mmol K and 65 mmol Na [high-potassium, high-sodium meal (HKHN)], and a control meal with 3 mmol K and 6 mmol Na (low-potassium, low-sodium meal) on 3 separate occasions in a randomized crossover trial. Brachial artery FMD, carotid-femoral PWV, central AIx, and blood pressure (BP) were measured while participants were fasting and at 30, 60, 90, and 120 min after meals. Results: Compared with the LKHN, the addition of potassium (HKHN) significantly attenuated the postmeal decrease in FMD (P-meal by time interaction , 0.05). FMD was significantly lower after the LKHN than after the HKHN at 30 min (P , 0.01). AIx decreased after all meals (P , 0.05). There were no significant differences in AIx, PWV, or BP between treatments over time. Conclusion: The addition of potassium to a high-sodium meal attenuates the sodium-induced postmeal reduction in endothelial function as assessed by FMD. This trial was registered at

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Brachial artery low-flow-mediated constriction is increased early after coronary intervention and reduces during recovery after acute coronary syndrome: characterization of a recently described index of vascular function

Cited by 48 publications

References 29 publications

Low-Flow Mediated Constriction is Endothelium-Dependent

Low-Flow Mediated Constriction is Endothelium-Dependent

Brachial Low-Flow-Mediated Constriction is Associated with Delayed Brachial Flow-Mediated Dilation

Effect of sodium and potassium supplementation on vascular and endothelial function: a randomized controlled trial

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