Brachytherapy for early endometrial carcinoma: a comparative study with long-term follow-up

Rose, Peter G.; Tak, Won K.; Fitzgerald, Thomas J.; Reale, Frank R.; Hunter, Richard; Nelson, Beth E.

doi:10.1046/j.1525-1438.1999.09901.x

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…More importantly, the amount of myometrial invasion, defined as invasion of the inner one‐third versus the middle one‐third, albeit arbitrary, seems to have significant implications on treatment decisions. Whether or not to recommend adjuvant radiation therapy in patients with invasion less than or equal to one‐third of the myometrium is debatable 3–5. However, it is unclear whether the depth of myometrial invasion in patients with Stage IB endometrial carcinoma has an impact on their overall outcome.…”

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confidence: 99%

Transcatheter left atrial appendage occlusion with Amplatzer devices to obviate anticoagulation in patients with atrial fibrillation

Meier

Palacios

Windecker

et al. 2003

Cathet Cardio Intervent

204

132

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It is assumed that over 90% of clinically apparent embolisms in atrial fibrillation originate from the left atrial appendage. Recently, a percutaneous method (PLAATO technique) to occlude the left atrial appendage to the end of preventing thromboembolic complications of atrial fibrillation has been introduced into clinical practice. This technique is quite intricate and requires general anesthesia. The Amplatzer atrial septal occluder lends itself for a more simple approach to this intervention. The first 16 patients treated at four centers are described. Their age varied from 58 to 83 years. All suffered from atrial fibrillation but eight of them were in sinus rhythm at the time of implantation. All but two procedures were done under local anesthesia of the groin only. There was one technical failure (device embolization) requiring surgery. All other patients left the hospital a day after the procedure without complications. There were no problems or embolic events during an overall follow-up of 5 patient-years and all left atrial appendages were completely occluded without evidence of thrombosis at the atrial side of the device at the latest follow-up echocardiography. With the Amplatzer technique, the left atrial appendage can be percutaneously occluded with a venous puncture under local anesthesia, without echocardiographic guidance, and at a reasonable risk. It remains to be evaluated in larger series or randomized trials how the simpler Amplatzer technique compares with the complex PLAATO technique, and whether left atrial appendage closure is competitive with oral anticoagulation with warfarin or the novel ximelagatran to prevent thromboembolism in atrial fibrillation.

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confidence: 99%