Brachytherapy for primary and recurrent nasopharyngeal carcinoma: treatment techniques and results

Maâlej, M.; Ammar, C. Nasr Ben; Kochbati, L.; Frikha, H.; Hentati, Dalenda; Gargouri, W.; Besbes, M.

doi:10.1016/j.canrad.2006.12.001

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…More advantageous. [7] Intensity-modulated conformal radiotherapy has the unique advantage of adjusting the irradiation intensity of the tumor target area and adjacent sensitive organs separately: the dose distribution in the target area is uniform, and the side effects of normal tissues are small. Through the adjustment of the dose intensity, the tumor target area is accurately irradiated, so that the tumor can obtain Higher irradiation doses and fractional doses than conventional radiotherapy, while significantly reducing the dose of surrounding normal tissues, protecting normal organ function and improving quality of life.…”

Section: Imrt For Nasopharyngeal Carcinomamentioning

confidence: 99%

IMRT Combined with Cetuximab for Locally Recurrent Nasopharyngeal Carcinoma Case and Literature Review

Zy¹,

Zhu²,

Wang³

et al. 2021

ACMCR

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Section: Imrt For Nasopharyngeal Carcinomamentioning

confidence: 99%

IMRT Combined with Cetuximab for Locally Recurrent Nasopharyngeal Carcinoma Case and Literature Review

Zy¹,

Zhu²,

Wang³

et al. 2021

ACMCR

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“…Recent advances in radiation therapy have improved the conformality of the treatment delivery and improved the clinical outcomes. Employment of Intensity modulated radiotherapy (IMRT), Image guided radiotherapy (IGRT) and Brachytherapy [28] represents promising techniques that allow delivering a high dose with maximal sparing of normal tissues [29] making radiotherapy more effective.…”

Section: Radiation Therapy For Cancermentioning

confidence: 99%

Cancer Therapeutics: Emerging Targets and Trends

Ullah¹

2008

CCTR

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Several decades of investigation concerning the cause and cure of cancer have revealed major discrepancies in the response of different cancer types towards a particular therapy and therefore a need for more effective approaches has been conceived. It is known that cancer development irrespective of its origin occurs due to the compromises that normal cells make in critical pathways, thereby allowing to transform into a tumor. It is thus conceivable that the most effective cancer therapy requires multiple targeting of molecular alterations responsible for malignant transformation. In this context, the development of combinational therapies aimed at multi-cornered attack on cancer cells is of particular significance. The present article is a brief review of the novel trends emerging in cancer therapeutics with special emphasis on epigenetic therapy, cancer stem cell therapy, modern radiotherapy, target based cancer therapy and polyphenol therapy.

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“…There is evidence of interest in 3D printing for radiotherapy applications (5,9,10,16,19,20) and specifically in brachytherapy (4,21–24) . There is even interest in using 3D printing to construct custom GYN applicators (3,25) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of PC‐ISO for customized, 3D printed, gynecologic HDR brachytherapy applicators

Cunha

Mellis

Sethi

et al. 2015

J Applied Clin Med Phys

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The purpose of this study was to evaluate the radiation attenuation properties of PC‐ISO, a commercially available, biocompatible, sterilizable 3D printing material, and its suitability for customized, single‐use gynecologic (GYN) brachytherapy applicators that have the potential for accurate guiding of seeds through linear and curved internal channels. A custom radiochromic film dosimetry apparatus was 3D‐printed in PC‐ISO with a single catheter channel and a slit to hold a film segment. The apparatus was designed specifically to test geometry pertinent for use of this material in a clinical setting. A brachytherapy dose plan was computed to deliver a cylindrical dose distribution to the film. The dose plan used an 192Ir source and was normalized to 1500 cGy at 1 cm from the channel. The material was evaluated by comparing the film exposure to an identical test done in water. The Hounsfield unit (HU) distributions were computed from a CT scan of the apparatus and compared to the HU distribution of water and the HU distribution of a commercial GYN cylinder applicator. The dose depth curve of PC‐ISO as measured by the radiochromic film was within 1% of water between 1 cm and 6 cm from the channel. The mean HU was ‐10 for PC‐ISO and ‐1 for water. As expected, the honeycombed structure of the PC‐ISO 3D printing process created a moderate spread of HU values, but the mean was comparable to water. PC‐ISO is sufficiently water‐equivalent to be compatible with our HDR brachytherapy planning system and clinical workflow and, therefore, it is suitable for creating custom GYN brachytherapy applicators. Our current clinical practice includes the use of custom GYN applicators made of commercially available PC‐ISO when doing so can improve the patient's treatment.PACS number: none

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Brachytherapy for primary and recurrent nasopharyngeal carcinoma: treatment techniques and results

Cited by 7 publications

References 20 publications

IMRT Combined with Cetuximab for Locally Recurrent Nasopharyngeal Carcinoma Case and Literature Review

IMRT Combined with Cetuximab for Locally Recurrent Nasopharyngeal Carcinoma Case and Literature Review

Cancer Therapeutics: Emerging Targets and Trends

Evaluation of PC‐ISO for customized, 3D printed, gynecologic HDR brachytherapy applicators

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