Brachytherapy in paediatric craniopharyngiomas: a systematic review and meta-analysis of recent literature

Guimarães, Mário; Cardeal, Daniel Dante; Teixeira, Manoel Jacobsen; Lúcio, José Erasmo Dal Col; Sanders, Felipe Hada; Kuromoto, R Kei; Matushita, Hamilton

doi:10.1007/s00381-021-05378-3

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…This application has been particularly studied in intra-cavitary brachytherapy, where a radioisotope is injected into the tumor cyst cavity, typically through an Ommaya reservoir. The most common radioisotopes are beta-emitting agents, including phosphorus-32 ( 32 P), yttrium-90 ( 90 Y), resulting in radiation dosages, ranging between 150-500 Gy, delivered to the cyst wall [57,58]. A recent systematic review of intra-cavitary brachytherapy in cystic craniopharyngiomasv [58] summarized findings from eight retrospective trials comprising 228 patients (66 children) and found tumor reduction responses in approximately 70% of cases, which was consistent with smaller historical trials [59][60][61][62][63].…”

Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

“…The most common radioisotopes are beta-emitting agents, including phosphorus-32 ( 32 P), yttrium-90 ( 90 Y), resulting in radiation dosages, ranging between 150-500 Gy, delivered to the cyst wall [57,58]. A recent systematic review of intra-cavitary brachytherapy in cystic craniopharyngiomasv [58] summarized findings from eight retrospective trials comprising 228 patients (66 children) and found tumor reduction responses in approximately 70% of cases, which was consistent with smaller historical trials [59][60][61][62][63]. However, treatment response was much more pronounced in purely cystic versus mixed solid-cystic lesions, particularly in the pediatric population (89% vs. 58%, respectively) [58].…”

Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

“…A recent systematic review of intra-cavitary brachytherapy in cystic craniopharyngiomasv [58] summarized findings from eight retrospective trials comprising 228 patients (66 children) and found tumor reduction responses in approximately 70% of cases, which was consistent with smaller historical trials [59][60][61][62][63]. However, treatment response was much more pronounced in purely cystic versus mixed solid-cystic lesions, particularly in the pediatric population (89% vs. 58%, respectively) [58]. Higher rates of visual (64% vs. 48%) and endocrine (20% vs. 7%) improvement were also observed in cystic versus mixed solid-cystic tumors but only when analyzing pediatric trials alone, as opposed to inclusion of mixed adult/pediatric trials.…”

Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

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The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas

Hong

Omay

2022

Current Oncology

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Craniopharyngiomas are rare, benign primary brain tumors that arise from remnants of the craniopharyngeal duct epithelium within the sellar and suprasellar region. Despite their benign biology, they may cause significant morbidity, secondary to involvement of nearby eloquent neural structures, such as the pituitary gland, hypothalamus, and optic apparatus. Historically, aggressive surgical resection was the treatment goal to minimize risk of tumor recurrence via open transcranial midline, anterolateral, and lateral approaches, but could lead to clinical sequela of visual, endocrine, and hypothalamic dysfunction. However, recent advances in the endoscopic endonasal approach over the last decade have mostly supplanted transcranial surgery as the optimal surgical approach for these tumors. With viable options for adjuvant radiation therapy, targeted medical treatment, and alternative minimally invasive surgical approaches, the management paradigm for craniopharyngiomas has shifted from aggressive open resection to more minimally invasive but maximally safe resection, emphasizing quality of life issues, particularly in regards to visual, endocrine, and hypothalamic function. This review provides an update on current multi-modal approaches for craniopharyngiomas, highlighting the modern surgical treatment paradigm for this disease entity.

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Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

Section: Stereotactic Cyst Decompressionmentioning

confidence: 99%

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The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas

Hong

Omay

2022

Current Oncology

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“…Brachytherapy involves implanting radioactive material inside the body and has been indicated as an alternative for treating cystic craniopharyngiomas. In a recent systematic review and meta-analysis, radioisotope brachytherapy in treating predominant monocystic or multi-cystic craniopharyngiomas showed effective tumor control and minimal morbidity, especially in the pediatric population [ 69 ]. Several reports have demonstrated that intracavitary brachytherapy irradiation with β -emitting sources such as phosphorus-32 (P-32) or yttrium-90 can be successful in treating cystic craniopharyngiomas while minimizing morbidities [ 70 , 71 ].…”

Section: Radiotherapymentioning

confidence: 99%

Current Approaches to Craniopharyngioma Management

Diaz¹,

Kwak²,

Root³

et al. 2022

Front. Biosci. (Landmark Ed)

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Craniopharyngiomas (CP) are rare noncancerous brain tumors located in the skull base. To date, CP remain challenging-to-resect tumors, owing to their difficult location and invasive potential, with profound adverse effects for the patient if left to grow. Indeed, gross total resection may also be accompanied by unwelcome sequalae, underscoring the need for continued investigation. In the present work, we provide a scoping review of current CP management, with emphasis on our knowledge of their genesis, available treatment options, post-intervention clinical outcomes. Leading theories of CP development are (1) the embryonic theory, explaining the development of adamantinomatous CP from epithelial remnants of Rathke's pouch and (2) the metaplastic theory, which describes papillary CP development as a result of adenohypophyseal cell metaplasia. Treatment may include surgery, intracystic therapy, or irradiation depending on tumor size, history and location. However, whether a single ideal approach and timing for CP intervention exists remains debated. We appraise and critique these areas with priority for emerging basic results and innovation.

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Update on management of craniopharyngiomas

Henderson

Schwartz

2021

J Neurooncol

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Brachytherapy in paediatric craniopharyngiomas: a systematic review and meta-analysis of recent literature

Cited by 6 publications

References 38 publications

The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas

The Role of Surgical Approaches in the Multi-Modal Management of Adult Craniopharyngiomas

Current Approaches to Craniopharyngioma Management

Update on management of craniopharyngiomas

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