Brachytherapy technology and physics practice since 1950: a half-century of progress

Williamson, Jeffrey F.

doi:10.1088/0031-9155/51/13/r18

Cited by 67 publications

(40 citation statements)

References 120 publications

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“…Historically, the preferred treatment choice for localized prostate cancer has been radical prostatectomy [2] . More recently, there has been an increasing shift towards radiation treatment, with brachytherapy at the forefront of treatment options.…”

Section: Introductionmentioning

confidence: 99%

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

et al. 2013

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. (2013). BrachyView: Proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy. Medical Physics, 40 (4), 041709-1-041709-9.Brachyview: proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy AbstractPurpose: The conformity of the achieved dose distribution to the treatment plan strongly correlates with the accuracy of seed implantation in a prostate brachytherapy treatment procedure. Incorrect seed placement leads to both short and long term complications, including urethral and rectal toxicity. The authors present BrachyView, a novel concept of a fast intraoperative treatment planning system, to provide real-time seed placement information based on in-body gamma camera data. BrachyView combines the high spatial resolution of a pixellated silicon detector (Medipix2) with the volumetric information acquired by a transrectal ultrasound (TRUS). The two systems will be embedded in the same probe so as to provide anatomically correct seed positions for intraoperative planning and postimplant dosimetry. Dosimetric calculations are based on the TG-43 method using the real position of the seeds. The purpose of this paper is to demonstrate the feasibility of BrachyView using the Medipix2 pixel detector and a pinhole collimator to reconstruct the real-time 3D position of low dose-rate brachytherapy seeds in a phantom. Methods: BrachyView incorporates three Medipix2 detectors coupled to a multipinhole collimator. Three-dimensionally triangulated seed positions from multiple planar images are used to determine the seed placement in a PMMA prostate phantom in real time. MATLAB codes were used to test the reconstruction method and to optimize the device geometry. Results: The results presented in this paper show a 3D position reconstruction accuracy of the seed in the range of 0.5-3 mm for a 10-60 mm seed-to-detector distance interval (Z direction), respectively. The BrachyView system also demonstrates a spatial resolution of 0.25 mm in the XY plane for sources at 10 mm distance from Medipix2 detector plane, comparable to the theoretical value calculated for an equivalent gamma camera arrangement. The authors successfully demonstrated the capability of BrachyView for real-time imaging (using a 3 s data acquisition time) of different brachytherapy seed configurations (with an activity of 0.05 U) throughout a 60 × 60 × 60 mm3 Perspex prostate phantom. Conclusions: The newly developed miniature gamma camera component of BrachyView, with its high spatial resolution and real time capability, allows accurate 3D localization of seeds in a prostate phantom. Combination of the gamma camera with TRUS in a single probe will complete the BrachyView system. © 2013 American Association of Physicists in Medicine. Keywords dose, low, camera, gamma, prostate, body, rate, novel, principle, proof, brachyview, brachytherapy Disciplines Engineering | Science and Technology Studies Publication DetailsPetasecca, M., Loo, K. J., Safavi-Naeini, M., Han, Z., Metcalfe, P. E., Meikle...

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Section: Introductionmentioning

confidence: 99%

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

et al. 2013

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“…HDR‐BRT is performed to administer a high dose to unresected or residual primary tumor in the vaginal vault. ( 1 , 2 , 3 ) …”

Section: Introductionmentioning

confidence: 99%

Local tumor control probability to evaluate an applicator‐guided volumetric‐modulated arc therapy solution as alternative of 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecological cancer

Pedicini¹,

Strigari

Caivano³

et al. 2013

J Applied Clin Med Phys

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The purpose of this study was to evaluate the applicator‐guided volumetric‐modulated arc therapy (AGVMAT) solution as an alternative to high‐dose‐rate brachytherapy (HDR‐BRT) treatment of the vaginal vault in patients with gynecological cancer (GC). AGVMAT plans for 51 women were developed. The volumetric scans used for plans were obtained with an implanted CT‐compatible vaginal cylinder which provides spatial registration and immobilization of the gynecologic organs. Dosimetric and radiobiological comparisons for planning target volume (PTV) and organs at risk (OARs) were performed by means of a dose‐volume histogram (DVH), equivalent uniform dose (EUD), and local tumor control probability (LTCP). In addition, the integral dose and the overall delivery time, were evaluated. The HDR‐BRT averages of EUD and minimum LTCP were significantly higher than those of AGVMAT. Doses for the OARs were comparable for the bladder and sigmoid, while, although HDR‐BRT was able to better spare the bowel, AGVMAT provided a significant reduction of normald2cc, normald1cc, and dmax (p<0.01) for the rectum. AGVMAT integral doses were higher than HDR‐BRT with low values in both cases. Delivery times were about two or three times higher for HDR‐BRT with respect to the single arc technique (AGVMAT1) and dual arc technique (AGVMAT2), respectively. The applicator‐guided volumetric‐modulated arc therapy seems to have the potential of improving rectum avoidance. However, brachytherapy improves performance in terms of PTV coverage, as demonstrated by a greater EUD and better LTCP curves.PACS number: 87

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“…Another technique that generates high depth-dose gradients (up to 20%.mm -1 ) is Brachytherapy (BT), on account on inverse square law and photon attenuation by tissues. It is used for treating localized and small-scale tumors (gynaecologic, prostatic, bronchial, head & neck, breast or esophagic) and involves sources ( 192 Ir, 137 Cs, 125 I) placed within or next to the tumor [1][2]. Sources may be placed into natural body cavities (intracavitary) or invasively into solid tissues (interstitial implants).…”

Section: Introductionmentioning

confidence: 99%

Intracavitary in vivo dosimetry based on multichannel fiber-coupled Radioluminescence and Optically Stimulated Luminescence of Al<inf>2</inf>O<inf>3</inf>:C

Spasic

Magne

Aubineau-Lanièce

et al. 2011

2011 2nd International Conference on Advancements in Nuclear Instrumentation, Measurement Methods and Their Applications

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Real-time dose measurements may also be performed by recording the RadioLuminescence (RL), spontaneously emitted by the crystals during irradiation. In this case, a correction method is implemented to correct for stem effect influence (Cerenkov and scintillation generated within the fibers). For BT, the dual-fiber subtraction method is used (using a reference fiber) whereas the time discrimination method is used for IMRT. The experimental dose distribution leads to an underestimation of the source-sensor distance presumably due to energy dependence of the alumina crystal at low photon energy. At the time being, Monte-Carlo modeling of the FODC is performed with the aim to estimate this energy dependence and finally correct for it. Finally, metrological and preclinical validations are still running at Centre Léon Bérard (Lyon, France) in the purpose of checking the compliance of the FODC prototypes with treatment specifications and medical constraints.

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Brachytherapy technology and physics practice since 1950: a half-century of progress

Cited by 67 publications

References 120 publications

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

Local tumor control probability to evaluate an applicator‐guided volumetric‐modulated arc therapy solution as alternative of 3D brachytherapy for the treatment of the vaginal vault in patients affected by gynecological cancer

Intracavitary in vivo dosimetry based on multichannel fiber-coupled Radioluminescence and Optically Stimulated Luminescence of Al<inf>2</inf>O<inf>3</inf>:C

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