Bradycardia Following Intravenous Administration of Succinylcholine Chloride to Infants and Children

Sleep Effect of Rectal Methohexitone (10 mg/kg) in Children Premedicated for Anaesthesia

“…Adequate anticholinergic premedication was considered necessary for the children in this study. The trigeminovagal oculocardiac reflex during ophthalmological surgery is dose-dependently diminished by atropine or glycopyrrolate as shown in adults by Kar hunen et al [1984], Halothane provokes bra dycardia [Marshall and Wollman, 1985], as does suxamethonium [Leigh et al, 1957], Anticholinergic premedication is generally considered unnecessary by some [Eger, 1962;Mirakhur et al, 1979], but the opinion about its use in infants and children should be considered separately [Mirakhur, 1979].…”

Two Episodes of Cardiac Arrest in One Week

“…Since then, however, Leigh, McCoy, Belton, and Lewis (1957) have reported bradycardia following the administration of suxamethonium, and have suggested its use could lead to cardiac arrest. Bullough (1959) has reported cases of cardiac arrest when an intermittent injection technique has been used.…”

The Effect of Succinylcholine on the Isolated Mammalian Heart

“…This has been reported as frequently as 80% in one series of cases (Mathias et al 1970). Succinylcholine may cause profound negative chronotropy after the administration of a single injection in certain 'at risk' groups of patientsthe badly burned subject (Tolmie et al 1967, Belin & Karleen 1966, small children (Leigh et al 1957), digitalized patients (Dowdy & Fabian 1963) and following damage to the spinal cord (Smith & Grenvik 1970).…”

“…In man the most commonly reported action of succinylcholine on the cardiovascular system is a negative chronotropic one (Beretervide 1955, Johnstone 1955, Leigh et al 1957, Lupprian & Churchill-Davidson 1960, Williams et al 1961, Galindo & Davis 1962, Gologorsky & Umanov 1970, Mathias et al 1970. Less frequently reported are hypotension (Adams & Hall 1962, Williams et al 1961, hypertension (Galindo & Davis 1962) and ventricular extrasystoles and ventricular fibrillation (Tolmie et al 1967, Belin & Karleen 1966, Vanner et al 1970, Dowdy & Fabian 1963.…”

“…These differ as to the precise action of the drug, and there are also numerous diverse theories about its site of action. Complications have occurred with the clinical use of succinylcholine, including bradycardia (Johnstone 1955, Beretervide 1955, Leigh et al 1957, Williams et al 1961, Galindo & Davis 1962, Tolmie et al 1967, Gologorsky & Umanov 1970, Mathias et al 1970, tachycardia (Beretervide 1955, Lupprian & Churchill-Davidson 1960, Conway 1961, Adams & Hall 1962, Galindo & Davis 1962, hypotension (Paton 1959, Adams & Hall 1962, Galindo & Davis 1962 and hypertension (Beretervide 1955, Johnstone 1955, Paton 1959, Conway 1961, Williams et al 1961, Galindo & Davis 1962, Goodman & Gilman 1965. More serious cardiac effects have also been reported, including ventricular arrhythmias (Lupprian & Churchill-Davidson 1960, Dowdy & Fabian 1963, Vanner et al 1970) and ventricular fibrillation and arrest (Tolmie et al 1967, Belin & Karleen 1966, Vanner et al 1970.…”