Bradykinin-evoked scratching responses in complete Freund's adjuvant-inflamed skin through activation of B1 receptor

Liang, Jian; He, Yanbing; Ji, Wenjin

doi:10.1258/ebm.2011.011308

Cited by 17 publications

(18 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But unlike the case for normal skin, the bradykinin-evoked wiping in an area of CHS was accompanied by robust scratching behavior. A similar phenomenon was also observed in the lesional skin of patients with atopic dermatitis and in mouse skin inflamed with complete Freund's adjuvant [7,29]. There are a number of potential neural mechanisms that could be explored.…”

Section: Discussionsupporting

confidence: 53%

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity

Qu²,

Shimada³

et al. 2014

Neuroscience Letters

View full text Add to dashboard Cite

Chemical pruritogens and algogens evoke primarily itch and pain, respectively, when administered to the skin of healthy human subjects. However, the dominant sensory quality elicited by an algesic chemical stimulus may change in patients with chronic itch where bradykinin, elicits itch in addition to pain. Here we tested whether normally pruritic and algesic chemicals evoked abnormal itch- or pain-like behaviors in the mouse after the development of contact hypersensitivity (CHS), an animal model of allergic contact dermatitis. Mice previously sensitized to a hapten (squaric acid dibutylester) applied to the abdomen, exhibited spontaneous itch-like scratching and pain-like wiping directed to the site on the cheek of the CHS elicited by a subsequent challenge with the same hapten. In comparison with responses of control mice, CHS mice exhibited a significant increase in the scratching evoked by bovine adrenal medulla 8–22, a peptide that elicits a histamine-independent itch, but did not alter the scratching to histamine. Bradykinin, an algogen that elicited only wiping in control mice, additionally evoked significant scratching in CHS mice. Thus, within an area of CHS, histamine-independent itch is enhanced and chemically evoked pain is accompanied by itch.

show abstract

Section: Discussionsupporting

confidence: 53%

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity

Qu²,

Shimada³

et al. 2014

Neuroscience Letters

View full text Add to dashboard Cite

show abstract

“…When inflammation is induced by complete freunds adjuvant (CFA), subsequent application of bradykinin causes robust scratching. This behavior is mediated by the kinin B1 receptor [82]. Both kinin receptors, B1 and B2, are shown to contribute to itch.…”

Section: Reviewmentioning

confidence: 99%

Molecular signaling and targets from itch: lessons for cough

LaVinka

Dong

2013

Cough

View full text Add to dashboard Cite

Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

show abstract

“…In chronic itch patients, scratching-evoked sensation can be perceived as itch and produce an “itch-scratch-itch” cycle to exacerbate itch. In some chronic itch conditions such as atopic dermatitis, even painful stimuli could be perceived as itch [57;60;86]. Continuous scratching not only increases the risk of skin infection, but also disrupts the social life of patients [75;119;151].…”

Section: Introductionmentioning

confidence: 99%

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Liu

2013

Pflugers Arch - Eur J Physiol

179

157

View full text Add to dashboard Cite

Itch and pain are closely related but distinct sensations. They share largely overlapping mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch-mediating primary sensory neurons are equipped with distinct receptors and ion channels for itch transduction, including Mas-related G protein-coupled receptors (Mrgprs), protease-activated receptors (PARs), histamine receptors, bile acid receptor (TGR5), toll-like receptors (TLRs), and transient receptor potential subfamily V1/A1 (TRPV1/A1). Recent progress has indicated the existence of an itch-specific neuronal circuitry. The MrgprA3-expressing primary sensory neurons exclusively innervate the epidermis of skin and their central axons connect with gastrin-releasing peptide receptor (GRPR)-expressing neurons in the superficial spinal cord. Notably, ablation of MrgprA3-expressing primary sensory neurons or GRPR-expressing spinal cord neurons results in selective reduction in itch but not pain. Chronic itch results from dysfunction of the immune and nervous system and can manifest as neural plasticity, despite the fact that chronic itch is often treated by dermatologists. While differences between acute pain and acute itch are striking, chronic itch and chronic pain share many similar mechanisms, including peripheral sensitization (increased responses of primary sensory neurons to itch and pain mediators), central sensitization (hyperactivity of spinal projection neurons and excitatory interneurons), loss of inhibitory control in the spinal cord, and neuro-immune and neuro-glial interactions. Notably, painful stimuli can elicit itch in some chronic conditions (e.g., atopic dermatitis) and some drugs for treating chronic pain are also effective in chronic itch. Thus, itch and pain have more similarities in pathological and chronic conditions.

show abstract

Bradykinin-evoked scratching responses in complete Freund's adjuvant-inflamed skin through activation of B1 receptor

Cited by 17 publications

References 44 publications

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity

Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity

Molecular signaling and targets from itch: lessons for cough

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Contact Info

Product

Resources

About